登録情報 データベース : PDB / ID : 4cfl 構造の表示 ダウンロードとリンクタイトル N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH LY303511 要素BRD4 PROTEIN 詳細 キーワード CELL CYCLE / INHIBITOR / HISTONE / EPIGENETIC READER / ANTAGONIST / KINASE機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
RNA polymerase II C-terminal domain binding / P-TEFb complex binding / negative regulation of DNA damage checkpoint / host-mediated suppression of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / histone reader activity / : ... RNA polymerase II C-terminal domain binding / P-TEFb complex binding / negative regulation of DNA damage checkpoint / host-mediated suppression of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / histone reader activity / : / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / p53 binding / chromosome / regulation of inflammatory response / histone binding / Potential therapeutics for SARS / positive regulation of canonical NF-kappaB signal transduction / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / protein serine/threonine kinase activity / DNA damage response / chromatin binding / regulation of transcription by RNA polymerase II / chromatin / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus 類似検索 - 分子機能 Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / Brdt, bromodomain, repeat I / Brdt, bromodomain, repeat II / NET domain superfamily / NET domain profile. / : / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like ... Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / Brdt, bromodomain, repeat I / Brdt, bromodomain, repeat II / NET domain superfamily / NET domain profile. / : / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain-like / Histone Acetyltransferase; Chain A / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain (BrD) profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Up-down Bundle / Mainly Alpha 類似検索 - ドメイン・相同性 8-phenyl-2-piperazin-1-yl-chromen-4-one / Bromodomain-containing protein 4 / BRD4 protein 類似検索 - 構成要素生物種 HOMO SAPIENS (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.32 Å 詳細データ登録者 Chung, C. / Dittmann, A. / Drewes, G. 引用ジャーナル : Acs Chem.Biol. / 年 : 2014タイトル : The Commonly Used Pi3-Kinase Probe Ly294002 is an Inhibitor of Bet Bromodomains.著者 : Dittmann, A. / Werner, T. / Chung, C. / Savitski, M.M. / Falth Savitski, M. / Grandi, P. / Hopf, C. / Lindon, M. / Neubauer, G. / Prinjha, R.K. / Bantscheff, M. / Drewes, G. 履歴 登録 2013年11月18日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2014年1月15日 Provider : repository / タイプ : Initial release改定 1.1 2014年2月26日 Group : Database references改定 1.2 2014年3月5日 Group : Database references改定 1.3 2024年5月8日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Other カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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