登録情報 | データベース: PDB / ID: 4yyz |
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タイトル | 11B-HYDROXYSTEROID DEHYDROGENASE TYPE I IN COMPLEX WITH INHIBITOR |
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要素 | Corticosteroid 11-beta-dehydrogenase isozyme 1 |
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キーワード | OXIDOREDUCTASE / DEHYDROGENASE INHIBITOR / BHSD |
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機能・相同性 | 機能・相同性情報
11beta-hydroxysteroid dehydrogenase / 11-beta-hydroxysteroid dehydrogenase (NADP+) activity / cortisol dehydrogenase activity / 7beta-hydroxysteroid dehydrogenase (NADP+) / 7-beta-hydroxysteroid dehydrogenase (NADP+) activity / Glucocorticoid biosynthesis / steroid catabolic process / Prednisone ADME / steroid binding / lung development ...11beta-hydroxysteroid dehydrogenase / 11-beta-hydroxysteroid dehydrogenase (NADP+) activity / cortisol dehydrogenase activity / 7beta-hydroxysteroid dehydrogenase (NADP+) / 7-beta-hydroxysteroid dehydrogenase (NADP+) activity / Glucocorticoid biosynthesis / steroid catabolic process / Prednisone ADME / steroid binding / lung development / NADP binding / intracellular membrane-bounded organelle / endoplasmic reticulum membrane / protein homodimerization activity / membrane類似検索 - 分子機能 short chain dehydrogenase / Short-chain dehydrogenase/reductase, conserved site / Short-chain dehydrogenases/reductases family signature. / Short-chain dehydrogenase/reductase SDR / NAD(P)-binding Rossmann-like Domain / NAD(P)-binding domain superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 Chem-4JX / NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE / 11-beta-hydroxysteroid dehydrogenase 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.2 Å |
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データ登録者 | Branden, G. / Boden, C. / Ogg, D. |
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引用 | ジャーナル: Medchemcomm / 年: 2016 タイトル: Design of pyrozolo-pyrimidines as 11beta-HSD1 inhibitors through optimisation of molecular electrostatic potential. 著者: Robb, G.R. / Boyd, S. / Davies, C.D. / Dossiter, A.G. / Goldberg, F.W. / Kemmitt, P.D. / Scott, J.S. / Swales, J.G. |
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履歴 | 登録 | 2015年3月24日 | 登録サイト: RCSB / 処理サイト: PDBE |
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改定 1.0 | 2016年2月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年5月8日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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