登録情報 | データベース: PDB / ID: 4y73 |
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タイトル | Crystal structure of IRAK4 kinase domain with inhibitor |
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要素 | Interleukin-1 receptor-associated kinase 4 |
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キーワード | TRANSFERASE / Kinase / Inhibitor |
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機能・相同性 | 機能・相同性情報
IRAK4 deficiency (TLR5) / MyD88 dependent cascade initiated on endosome / TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation / MyD88 cascade initiated on plasma membrane / Toll signaling pathway / neutrophil migration / interleukin-33-mediated signaling pathway / toll-like receptor 9 signaling pathway / neutrophil mediated immunity / interleukin-1 receptor binding ...IRAK4 deficiency (TLR5) / MyD88 dependent cascade initiated on endosome / TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation / MyD88 cascade initiated on plasma membrane / Toll signaling pathway / neutrophil migration / interleukin-33-mediated signaling pathway / toll-like receptor 9 signaling pathway / neutrophil mediated immunity / interleukin-1 receptor binding / interleukin-1-mediated signaling pathway / MyD88-dependent toll-like receptor signaling pathway / IRAK4 deficiency (TLR2/4) / MyD88:MAL(TIRAP) cascade initiated on plasma membrane / toll-like receptor 4 signaling pathway / toll-like receptor signaling pathway / extrinsic component of plasma membrane / JNK cascade / TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling / positive regulation of smooth muscle cell proliferation / cytokine-mediated signaling pathway / Interleukin-1 signaling / PIP3 activates AKT signaling / kinase activity / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / positive regulation of canonical NF-kappaB signal transduction / cellular response to lipopolysaccharide / endosome membrane / non-specific serine/threonine protein kinase / intracellular signal transduction / protein serine kinase activity / innate immune response / protein serine/threonine kinase activity / protein kinase binding / magnesium ion binding / cell surface / extracellular space / ATP binding / nucleus / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Interleukin-1 receptor-associated kinase 4 / IRAK4, Death domain / : / Death-like domain superfamily / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 ...Interleukin-1 receptor-associated kinase 4 / IRAK4, Death domain / : / Death-like domain superfamily / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein tyrosine and serine/threonine kinase / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 Chem-XPY / Interleukin-1 receptor-associated kinase 4類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / フーリエ合成 / 解像度: 2.14 Å |
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データ登録者 | Lesburg, C.A. |
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引用 | ジャーナル: Acs Med.Chem.Lett. / 年: 2015 タイトル: Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4. 著者: Lim, J. / Altman, M.D. / Baker, J. / Brubaker, J.D. / Chen, H. / Chen, Y. / Fischmann, T. / Gibeau, C. / Kleinschek, M.A. / Leccese, E. / Lesburg, C. / Maclean, J.K. / Moy, L.Y. / Mulrooney, ...著者: Lim, J. / Altman, M.D. / Baker, J. / Brubaker, J.D. / Chen, H. / Chen, Y. / Fischmann, T. / Gibeau, C. / Kleinschek, M.A. / Leccese, E. / Lesburg, C. / Maclean, J.K. / Moy, L.Y. / Mulrooney, E.F. / Presland, J. / Rakhilina, L. / Smith, G.F. / Steinhuebel, D. / Yang, R. |
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履歴 | 登録 | 2015年2月13日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2015年5月20日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2015年7月15日 | Group: Database references |
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