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TitleDiscovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 6, Page 683-688, Year 2015
Publish dateFeb 13, 2015 (structure data deposition date)
AuthorsLim, J. / Altman, M.D. / Baker, J. / Brubaker, J.D. / Chen, H. / Chen, Y. / Fischmann, T. / Gibeau, C. / Kleinschek, M.A. / Leccese, E. ...Lim, J. / Altman, M.D. / Baker, J. / Brubaker, J.D. / Chen, H. / Chen, Y. / Fischmann, T. / Gibeau, C. / Kleinschek, M.A. / Leccese, E. / Lesburg, C. / Maclean, J.K. / Moy, L.Y. / Mulrooney, E.F. / Presland, J. / Rakhilina, L. / Smith, G.F. / Steinhuebel, D. / Yang, R.
External linksAcs Med. Chem. Lett. / PubMed:26101574
MethodsX-ray diffraction
Resolution2.14 Å
Structure data

PDB-4y73:
Crystal structure of IRAK4 kinase domain with inhibitor
Method: X-RAY DIFFRACTION / Resolution: 2.14 Å

Chemicals

ChemComp-XPY:
5-{[(1R,2S)-2-aminocyclohexyl]amino}-N-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / Kinase / Inhibitor

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