登録情報 | データベース: PDB / ID: 4x3v |
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タイトル | Crystal structure of human ribonucleotide reductase 1 bound to inhibitor |
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要素 | Ribonucleoside-diphosphate reductase large subunit |
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キーワード | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / Complex / reducatse / inhibitor / enzyme / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
ribonucleoside-diphosphate reductase activity / pyrimidine nucleobase metabolic process / cell proliferation in forebrain / ribonucleoside diphosphate metabolic process / positive regulation of G0 to G1 transition / 2'-deoxyribonucleotide biosynthetic process / mitochondrial DNA replication / ribonucleoside-diphosphate reductase complex / ribonucleoside-diphosphate reductase / ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ...ribonucleoside-diphosphate reductase activity / pyrimidine nucleobase metabolic process / cell proliferation in forebrain / ribonucleoside diphosphate metabolic process / positive regulation of G0 to G1 transition / 2'-deoxyribonucleotide biosynthetic process / mitochondrial DNA replication / ribonucleoside-diphosphate reductase complex / ribonucleoside-diphosphate reductase / ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor / Interconversion of nucleotide di- and triphosphates / deoxyribonucleotide biosynthetic process / protein heterotetramerization / response to ionizing radiation / DNA synthesis involved in DNA repair / positive regulation of G1/S transition of mitotic cell cycle / positive regulation of G2/M transition of mitotic cell cycle / cell projection / male gonad development / disordered domain specific binding / retina development in camera-type eye / nuclear envelope / DNA repair / neuronal cell body / mitochondrion / ATP binding / identical protein binding / cytosol類似検索 - 分子機能 Ribonucleotide reductase, class I , alpha subunit / Ribonucleotide reductase large subunit signature. / Ribonucleoside-diphosphate reductase large subunit / ATP-cone domain / ATP cone domain / ATP-cone domain profile. / Ribonucleotide reductase R1 subunit, N-terminal / Ribonucleotide reductase large subunit, N-terminal / Ribonucleotide reductase, all-alpha domain / Ribonucleotide reductase large subunit, C-terminal ...Ribonucleotide reductase, class I , alpha subunit / Ribonucleotide reductase large subunit signature. / Ribonucleoside-diphosphate reductase large subunit / ATP-cone domain / ATP cone domain / ATP-cone domain profile. / Ribonucleotide reductase R1 subunit, N-terminal / Ribonucleotide reductase large subunit, N-terminal / Ribonucleotide reductase, all-alpha domain / Ribonucleotide reductase large subunit, C-terminal / Ribonucleotide reductase, barrel domain / Anaerobic Ribonucleotide-triphosphate Reductase Large Chain / Anaerobic Ribonucleotide-triphosphate Reductase Large Chain - #20 / Alpha-Beta Barrel / Alpha Beta類似検索 - ドメイン・相同性 Chem-3X4 / THYMIDINE-5'-TRIPHOSPHATE / Ribonucleoside-diphosphate reductase large subunit類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.7 Å |
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データ登録者 | Dealwis, C.G. / Ahmad, M.F. / Alam, I. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R01GM100887-01 | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | R01CA100827-04A1 | 米国 |
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引用 | ジャーナル: J.Med.Chem. / 年: 2015 タイトル: Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators. 著者: Ahmad, M.F. / Huff, S.E. / Pink, J. / Alam, I. / Zhang, A. / Perry, K. / Harris, M.E. / Misko, T. / Porwal, S.K. / Oleinick, N.L. / Miyagi, M. / Viswanathan, R. / Dealwis, C.G. |
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履歴 | 登録 | 2014年12月1日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2015年11月11日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2016年1月6日 | Group: Database references |
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改定 1.2 | 2017年9月13日 | Group: Advisory / Author supporting evidence ...Advisory / Author supporting evidence / Database references / Derived calculations カテゴリ: citation / pdbx_audit_support ...citation / pdbx_audit_support / pdbx_struct_oper_list / pdbx_unobs_or_zero_occ_atoms Item: _citation.journal_id_CSD / _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operation |
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改定 1.3 | 2019年12月4日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.4 | 2023年9月27日 | Group: Advisory / Data collection ...Advisory / Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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