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Open data
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Basic information
Entry | Database: PDB / ID: 4rlp | ||||||
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Title | Human p70s6k1 with ruthenium-based inhibitor FL772 | ||||||
![]() | p70S6K1 | ||||||
![]() | TRANSFERASE/TRANSFERASE INHIBITOR / ![]() | ||||||
Function / homology | ![]() long-chain fatty acid import into cell / response to electrical stimulus involved in regulation of muscle adaptation / skeletal muscle atrophy / positive regulation of skeletal muscle tissue growth / regulation of glucose import / ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Domsic, J.F. / Barber-Rotenberg, J. / Salami, J. / Qin, J. / Marmorstein, R. | ||||||
![]() | ![]() Title: Development of Organometallic S6K1 Inhibitors. Authors: Qin, J. / Rajaratnam, R. / Feng, L. / Salami, J. / Barber-Rotenberg, J.S. / Domsic, J. / Reyes-Uribe, P. / Liu, H. / Dang, W. / Berger, S.L. / Villanueva, J. / Meggers, E. / Marmorstein, R. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 112 KB | Display | ![]() |
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PDB format | ![]() | 86.9 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 4rloC ![]() 3a62S C: citing same article ( S: Starting model for refinement |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components on special symmetry positions |
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Components
#1: Protein | Mass: 32691.326 Da / Num. of mol.: 1 / Fragment: UNP residues 85-372 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() References: UniProt: P23443, ![]() | ||
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#2: Chemical | ChemComp-72B / [( | ||
#3: Chemical | ChemComp-CL / ![]() #4: Water | ChemComp-HOH / | ![]() |
-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 3.32 Å3/Da / Density % sol: 62.95 % |
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Crystal grow![]() | Temperature: 288 K / Method: vapor diffusion, hanging drop / pH: 8.5 Details: 0.1M Tris, 3.5M Sodium Formate, with staurosporine, pH 8.5, VAPOR DIFFUSION, HANGING DROP, temperature 288K |
-Data collection
Diffraction | Mean temperature: 100 K |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: ADSC QUANTUM 315 / Detector: CCD / Date: May 1, 2011 |
Radiation | Monochromator: a / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength![]() |
Reflection | Resolution: 2.79→29.91 Å / Num. all: 11157 / Num. obs: 10829 / % possible obs: 97.06 % / Observed criterion σ(F): 1 / Observed criterion σ(I): 1 / Redundancy: 4.4 % / Rsym value: 0.089 |
Reflection shell | Resolution: 2.794→2.893 Å / Redundancy: 4.2 % / Mean I/σ(I) obs: 2 / Num. unique all: 1028 / Rsym value: 0.678 / % possible all: 97.06 |
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Processing
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Refinement | Method to determine structure![]() ![]() Starting model: 3a62 Resolution: 2.79→29.91 Å / σ(F): 1.34 / Stereochemistry target values: ML
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Refinement step | Cycle: LAST / Resolution: 2.79→29.91 Å
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Refine LS restraints |
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LS refinement shell | Highest resolution: 2.7925 Å
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