Entry Database : PDB / ID : 4qfs Structure visualization Downloads & linksTitle Structure of AMPK in complex with Br2-A769662core activator and STAUROSPORINE inhibitor Components(5'-AMP-activated protein kinase subunit ...) x 2 5'-AMP-activated protein kinase catalytic subunit alpha-1 DetailsKeywords signaling protein/inhibitor/activator / CBM / Kinase / AMPK / signaling protein-inhibitor-activator complexFunction / homology Function and homology informationFunction Domain/homology Component
eukaryotic elongation factor-2 kinase activator activity / Energy dependent regulation of mTOR by LKB1-AMPK / positive regulation of mitochondrial transcription / Regulation of TP53 Activity through Phosphorylation / Macroautophagy / TP53 Regulates Metabolic Genes / [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase / nail development / [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity / : ... eukaryotic elongation factor-2 kinase activator activity / Energy dependent regulation of mTOR by LKB1-AMPK / positive regulation of mitochondrial transcription / Regulation of TP53 Activity through Phosphorylation / Macroautophagy / TP53 Regulates Metabolic Genes / [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase / nail development / [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity / : / regulation of stress granule assembly / histone H2BS36 kinase activity / regulation of peptidyl-serine phosphorylation / cold acclimation / positive regulation of peptidyl-lysine acetylation / lipid droplet disassembly / regulation of bile acid secretion / positive regulation of fatty acid oxidation / positive regulation of skeletal muscle tissue development / CAMKK-AMPK signaling cascade / import into nucleus / regulation of vesicle-mediated transport / nucleotide-activated protein kinase complex / : / negative regulation of hepatocyte apoptotic process / tau-protein kinase / protein kinase regulator activity / cellular response to ethanol / bile acid and bile salt transport / protein localization to lipid droplet / negative regulation of TOR signaling / bile acid signaling pathway / response to caffeine / motor behavior / positive regulation of protein targeting to mitochondrion / lipid biosynthetic process / AMP-activated protein kinase activity / negative regulation of tubulin deacetylation / tau-protein kinase activity / positive regulation of protein localization / AMP binding / cholesterol biosynthetic process / fatty acid oxidation / cellular response to nutrient levels / fatty acid homeostasis / negative regulation of lipid catabolic process / cellular response to glucose starvation / positive regulation of autophagy / energy homeostasis / regulation of microtubule cytoskeleton organization / response to UV / positive regulation of gluconeogenesis / negative regulation of TORC1 signaling / positive regulation of adipose tissue development / cellular response to calcium ion / negative regulation of insulin receptor signaling pathway / positive regulation of glycolytic process / response to activity / positive regulation of glucose import / response to gamma radiation / cellular response to glucose stimulus / response to hydrogen peroxide / regulation of circadian rhythm / ADP binding / Wnt signaling pathway / fatty acid biosynthetic process / autophagy / cellular response to hydrogen peroxide / neuron cellular homeostasis / response to estrogen / cellular response to prostaglandin E stimulus / glucose metabolic process / rhythmic process / cellular response to xenobiotic stimulus / glucose homeostasis / positive regulation of cold-induced thermogenesis / cellular response to oxidative stress / cellular response to hypoxia / negative regulation of translation / non-specific serine/threonine protein kinase / protein kinase activity / nuclear speck / response to xenobiotic stimulus / apical plasma membrane / axon / protein phosphorylation / negative regulation of gene expression / protein serine kinase activity / protein serine/threonine kinase activity / neuronal cell body / chromatin binding / dendrite / positive regulation of cell population proliferation / positive regulation of gene expression / protein-containing complex binding / chromatin / negative regulation of apoptotic process / protein kinase binding / positive regulation of DNA-templated transcription / signal transduction Similarity search - Function Double Stranded RNA Binding Domain - #60 / Double Stranded RNA Binding Domain / PRKAA1, UBA-like autoinhibitory domain / 5'-AMP-activated protein kinase alpha 1 catalytic subunit, C-terminal / : / AMP-activated protein kinase, alpha subunit, autoinhibitory domain / Association with the SNF1 complex (ASC) domain / ASC domain superfamily / 5'-AMP-activated protein kinase beta subunit, interaction domain / 5'-AMP-activated protein kinase beta subunit, interation domain ... Double Stranded RNA Binding Domain - #60 / Double Stranded RNA Binding Domain / PRKAA1, UBA-like autoinhibitory domain / 5'-AMP-activated protein kinase alpha 1 catalytic subunit, C-terminal / : / AMP-activated protein kinase, alpha subunit, autoinhibitory domain / Association with the SNF1 complex (ASC) domain / ASC domain superfamily / 5'-AMP-activated protein kinase beta subunit, interaction domain / 5'-AMP-activated protein kinase beta subunit, interation domain / AMPK, C-terminal adenylate sensor domain / Adenylate sensor of SNF1-like protein kinase / AMP-activated protein kinase, glycogen-binding domain / Glycogen recognition site of AMP-activated protein kinase / KA1 domain/Ssp2, C-terminal / Other non-globular / CBS domain superfamily / Domain in cystathionine beta-synthase and other proteins. / CBS domain / CBS domain / CBS domain profile. / Special / Immunoglobulin E-set / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Immunoglobulins / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homology Chem-32H / ADENOSINE MONOPHOSPHATE / STAUROSPORINE / 5'-AMP-activated protein kinase catalytic subunit alpha-1 / 5'-AMP-activated protein kinase subunit gamma-1 / 5'-AMP-activated protein kinase subunit beta-1 Similarity search - ComponentBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 3.55 Å DetailsAuthors Calabrese, M.F. / Kurumbail, R.G. CitationJournal : Structure / Year : 2014Title : Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms.Authors: Calabrese, M.F. / Rajamohan, F. / Harris, M.S. / Caspers, N.L. / Magyar, R. / Withka, J.M. / Wang, H. / Borzilleri, K.A. / Sahasrabudhe, P.V. / Hoth, L.R. / Geoghegan, K.F. / Han, S. / ... Authors : Calabrese, M.F. / Rajamohan, F. / Harris, M.S. / Caspers, N.L. / Magyar, R. / Withka, J.M. / Wang, H. / Borzilleri, K.A. / Sahasrabudhe, P.V. / Hoth, L.R. / Geoghegan, K.F. / Han, S. / Brown, J. / Subashi, T.A. / Reyes, A.R. / Frisbie, R.K. / Ward, J. / Miller, R.A. / Landro, J.A. / Londregan, A.T. / Carpino, P.A. / Cabral, S. / Smith, A.C. / Conn, E.L. / Cameron, K.O. / Qiu, X. / Kurumbail, R.G. History Deposition May 21, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Aug 6, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Aug 13, 2014 Group : Database referencesRevision 1.2 Aug 20, 2014 Group : Database referencesRevision 1.3 Aug 16, 2017 Group : Refinement description / Source and taxonomy / Category : entity_src_gen / softwareRevision 1.4 Nov 22, 2017 Group : Refinement description / Category : softwareItem : _software.classification / _software.contact_author ... _software.classification / _software.contact_author / _software.contact_author_email / _software.date / _software.language / _software.location / _software.name / _software.type / _software.version
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