Entry Database : PDB / ID : 4op3 Structure visualization Downloads & linksTitle Human GKRP bound to AMG-5112 and Sorbitol-6-phosphate ComponentsGlucokinase Regulatory Protein Details Keywords CARBOHYDRATE BINDING PROTEIN/INHIBITOR / SIS domain containing protein / Binds to and inhibits Glucokinase / Glucokinase / Liver / CARBOHYDRATE BINDING PROTEIN-INHIBITOR complexFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of glucokinase activity / glucose sensor activity / fructose-6-phosphate binding / carbohydrate derivative metabolic process / urate metabolic process / kinase inhibitor activity / Regulation of Glucokinase by Glucokinase Regulatory Protein / Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) / response to fructose / triglyceride homeostasis ... negative regulation of glucokinase activity / glucose sensor activity / fructose-6-phosphate binding / carbohydrate derivative metabolic process / urate metabolic process / kinase inhibitor activity / Regulation of Glucokinase by Glucokinase Regulatory Protein / Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) / response to fructose / triglyceride homeostasis / enzyme inhibitor activity / response to glucose / protein import into nucleus / glucose homeostasis / carbohydrate binding / enzyme binding / mitochondrion / nucleoplasm / cytoplasm / cytosol Similarity search - Function C-terminal lid domain of glucokinase regulatory protein / Glucokinase regulatory protein, conserved site / N-acetylmuramic acid 6-phosphate etherase/glucokinase regulatory protein / Glucokinase regulatory protein family signature. / SIS domain / SIS domain profile. / SIS domain superfamily / Glucose-6-phosphate isomerase like protein; domain 1 / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2.82 Å DetailsAuthors Jordan, S.R. / Chmait, S. CitationJournal : J.Med.Chem. / Year : 2015Title : Small Molecule Disruptors of the Glucokinase-Glucokinase Regulatory Protein Interaction: 5. A Novel Aryl Sulfone Series, Optimization Through Conformational Analysis.Authors: Tamayo, N.A. / Norman, M.H. / Bartberger, M.D. / Hong, F.T. / Bo, Y. / Liu, L. / Nishimura, N. / Yang, K.C. / Tadesse, S. / Fotsch, C. / Chen, J. / Chmait, S. / Cupples, R. / Hale, C. / ... Authors : Tamayo, N.A. / Norman, M.H. / Bartberger, M.D. / Hong, F.T. / Bo, Y. / Liu, L. / Nishimura, N. / Yang, K.C. / Tadesse, S. / Fotsch, C. / Chen, J. / Chmait, S. / Cupples, R. / Hale, C. / Jordan, S.R. / Lloyd, D.J. / Sivits, G. / Van, G. / St Jean, D.J. History Deposition Feb 4, 2014 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jul 30, 2014 Provider : repository / Type : Initial releaseRevision 1.1 Jun 24, 2015 Group : Database referencesRevision 1.2 Sep 20, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description / Structure summary Category : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ... _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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