登録情報 データベース : PDB / ID : 4nh9 構造の表示 ダウンロードとリンクタイトル Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity 要素Endoplasmin 詳細 キーワード CHAPERONE / a/b structure / endoplasmic reticulum機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
actin rod assembly / regulation of phosphoprotein phosphatase activity / : / ATF6 (ATF6-alpha) activates chaperone genes / sequestering of calcium ion / endoplasmic reticulum chaperone complex / sarcoplasmic reticulum lumen / protein folding in endoplasmic reticulum / Trafficking and processing of endosomal TLR / Scavenging by Class A Receptors ... actin rod assembly / regulation of phosphoprotein phosphatase activity / : / ATF6 (ATF6-alpha) activates chaperone genes / sequestering of calcium ion / endoplasmic reticulum chaperone complex / sarcoplasmic reticulum lumen / protein folding in endoplasmic reticulum / Trafficking and processing of endosomal TLR / Scavenging by Class A Receptors / sperm plasma membrane / cellular response to ATP / retrograde protein transport, ER to cytosol / low-density lipoprotein particle receptor binding / smooth endoplasmic reticulum / cellular response to manganese ion / endocytic vesicle lumen / response to endoplasmic reticulum stress / ATP-dependent protein folding chaperone / Post-translational protein phosphorylation / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / unfolded protein binding / melanosome / protein transport / protein folding / midbody / protein phosphatase binding / Interleukin-4 and Interleukin-13 signaling / collagen-containing extracellular matrix / response to hypoxia / endoplasmic reticulum lumen / focal adhesion / calcium ion binding / endoplasmic reticulum membrane / negative regulation of apoptotic process / perinuclear region of cytoplasm / endoplasmic reticulum / ATP hydrolysis activity / protein-containing complex / RNA binding / extracellular exosome / extracellular region / ATP binding / membrane / nucleus / cytosol 類似検索 - 分子機能 Endoplasmic reticulum targeting sequence. / Heat shock protein Hsp90, conserved site / Heat shock hsp90 proteins family signature. / HSP90, C-terminal domain / Heat shock protein Hsp90, N-terminal / Heat shock protein Hsp90 family / Hsp90 protein / Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase / Histidine kinase-like ATPase, C-terminal domain / Heat Shock Protein 90 ... Endoplasmic reticulum targeting sequence. / Heat shock protein Hsp90, conserved site / Heat shock hsp90 proteins family signature. / HSP90, C-terminal domain / Heat shock protein Hsp90, N-terminal / Heat shock protein Hsp90 family / Hsp90 protein / Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase / Histidine kinase-like ATPase, C-terminal domain / Heat Shock Protein 90 / Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase / Histidine kinase-like ATPases / Histidine kinase/HSP90-like ATPase / Histidine kinase/HSP90-like ATPase superfamily / Ribosomal protein S5 domain 2-type fold / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 解像度 : 2.77 Å 詳細データ登録者 Zuccola, H.J. / Ernst, J.T. 引用ジャーナル : Bioorg.Med.Chem.Lett. / 年 : 2014タイトル: Correlation between chemotype-dependent binding conformations of HSP90 alpha / beta and isoform selectivity-Implications for the structure-based design of HSP90 alpha / beta selective ... タイトル : Correlation between chemotype-dependent binding conformations of HSP90 alpha / beta and isoform selectivity-Implications for the structure-based design of HSP90 alpha / beta selective inhibitors for treating neurodegenerative diseases.著者 : Ernst, J.T. / Liu, M. / Zuccola, H. / Neubert, T. / Beaumont, K. / Turnbull, A. / Kallel, A. / Vought, B. / Stamos, D. 履歴 登録 2013年11月4日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2014年1月22日 Provider : repository / タイプ : Initial release改定 1.1 2024年2月28日 Group : Data collection / Database references / Derived calculationsカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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