- PDB-4nh9: Correlation between chemotype-dependent binding conformations of ... -
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Basic information
Entry
Database: PDB / ID: 4nh9
Title
Correlation between chemotype-dependent binding conformations of HSP90 alpha/beta and isoform selectivity
Components
Endoplasmin
Keywords
CHAPERONE / a/b structure / endoplasmic reticulum
Function / homology
Function and homology information
actin rod assembly / : / : / ATF6 (ATF6-alpha) activates chaperone genes / endoplasmic reticulum chaperone complex / sequestering of calcium ion / sarcoplasmic reticulum lumen / protein folding in endoplasmic reticulum / Trafficking and processing of endosomal TLR / Scavenging by Class A Receptors ...actin rod assembly / : / : / ATF6 (ATF6-alpha) activates chaperone genes / endoplasmic reticulum chaperone complex / sequestering of calcium ion / sarcoplasmic reticulum lumen / protein folding in endoplasmic reticulum / Trafficking and processing of endosomal TLR / Scavenging by Class A Receptors / sperm plasma membrane / retrograde protein transport, ER to cytosol / cellular response to ATP / low-density lipoprotein particle receptor binding / smooth endoplasmic reticulum / cellular response to manganese ion / endocytic vesicle lumen / response to endoplasmic reticulum stress / ATP-dependent protein folding chaperone / Post-translational protein phosphorylation / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / unfolded protein binding / melanosome / protein transport / protein folding / midbody / protein phosphatase binding / Interleukin-4 and Interleukin-13 signaling / collagen-containing extracellular matrix / response to hypoxia / endoplasmic reticulum lumen / focal adhesion / calcium ion binding / endoplasmic reticulum membrane / negative regulation of apoptotic process / perinuclear region of cytoplasm / endoplasmic reticulum / ATP hydrolysis activity / protein-containing complex / RNA binding / extracellular exosome / extracellular region / ATP binding / membrane / nucleus / cytosol Similarity search - Function
Endoplasmic reticulum targeting sequence. / Heat shock protein Hsp90, conserved site / Heat shock hsp90 proteins family signature. / HSP90, C-terminal domain / Heat shock protein Hsp90, N-terminal / Heat shock protein Hsp90 family / Hsp90 protein / Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase / Histidine kinase-like ATPase, C-terminal domain / Heat Shock Protein 90 ...Endoplasmic reticulum targeting sequence. / Heat shock protein Hsp90, conserved site / Heat shock hsp90 proteins family signature. / HSP90, C-terminal domain / Heat shock protein Hsp90, N-terminal / Heat shock protein Hsp90 family / Hsp90 protein / Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase / Histidine kinase-like ATPase, C-terminal domain / Heat Shock Protein 90 / Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase / Histidine kinase-like ATPases / Histidine kinase/HSP90-like ATPase / Histidine kinase/HSP90-like ATPase superfamily / Ribosomal protein S5 domain 2-type fold / 2-Layer Sandwich / Alpha Beta Similarity search - Domain/homology
Journal: Bioorg.Med.Chem.Lett. / Year: 2014 Title: Correlation between chemotype-dependent binding conformations of HSP90 alpha / beta and isoform selectivity-Implications for the structure-based design of HSP90 alpha / beta selective ...Title: Correlation between chemotype-dependent binding conformations of HSP90 alpha / beta and isoform selectivity-Implications for the structure-based design of HSP90 alpha / beta selective inhibitors for treating neurodegenerative diseases. Authors: Ernst, J.T. / Liu, M. / Zuccola, H. / Neubert, T. / Beaumont, K. / Turnbull, A. / Kallel, A. / Vought, B. / Stamos, D.
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