登録情報 データベース : PDB / ID : 4i0z 構造の表示 ダウンロードとリンクタイトル Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates 要素2-{(1S)-1-[(6-CHLORO-3,3-DIMETHYL-3,4-DIHYDROISOQUINOLIN-1-YL)AMINO]-2-PHENYLETHYL}-4-OXO-1,4-DIHYDROPYRIMIDINE-5-CARBONITRILE 詳細 キーワード hydrolase/hydrolase inhibitor / Aspartic protease / hydrolase-hydrolase inhibitor complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / amyloid-beta metabolic process / cellular response to manganese ion / prepulse inhibition ... memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / amyloid-beta metabolic process / cellular response to manganese ion / prepulse inhibition / detection of mechanical stimulus involved in sensory perception of pain / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / multivesicular body / hippocampal mossy fiber to CA3 synapse / response to lead ion / trans-Golgi network / recycling endosome / protein processing / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / late endosome / synaptic vesicle / peptidase activity / amyloid-beta binding / endopeptidase activity / aspartic-type endopeptidase activity / amyloid fibril formation / endosome / endosome membrane / early endosome / lysosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / enzyme binding / cell surface / Golgi apparatus / proteolysis / membrane / plasma membrane 類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Eukaryotic aspartyl protease / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ... Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Eukaryotic aspartyl protease / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / 分子置換 / 解像度 : 1.8 Å 詳細データ登録者 Lougheed, J.C. / Brecht, E. / Yao, N.H. 引用ジャーナル : Bioorg.Med.Chem.Lett. / 年 : 2013タイトル : Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.著者: Bowers, S. / Xu, Y.Z. / Yuan, S. / Probst, G.D. / Hom, R.K. / Chan, W. / Konradi, A.W. / Sham, H.L. / Zhu, Y.L. / Beroza, P. / Pan, H. / Brecht, E. / Yao, N. / Lougheed, J. / Tam, D. / Ren, Z. ... 著者 : Bowers, S. / Xu, Y.Z. / Yuan, S. / Probst, G.D. / Hom, R.K. / Chan, W. / Konradi, A.W. / Sham, H.L. / Zhu, Y.L. / Beroza, P. / Pan, H. / Brecht, E. / Yao, N. / Lougheed, J. / Tam, D. / Ren, Z. / Ruslim, L. / Bova, M.P. / Artis, D.R. 履歴 登録 2012年11月19日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2013年3月6日 Provider : repository / タイプ : Initial release改定 1.1 2013年4月24日 Group : Database references
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