登録情報 | データベース: PDB / ID: 4hkp |
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タイトル | Crystal structure of human orotidine 5'-monophosphate decarboxylase complexed with CMP-N3-oxide |
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要素 | Uridine 5'-monophosphate synthase |
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キーワード | LYASE/LYASE INHIBITOR / Alpha-Beta Barrel / decarboxylase / LYASE-LYASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
UMP biosynthetic process / orotate phosphoribosyltransferase / orotate phosphoribosyltransferase activity / pyrimidine nucleobase biosynthetic process / Pyrimidine biosynthesis / orotidine-5'-phosphate decarboxylase / orotidine-5'-phosphate decarboxylase activity / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process ...UMP biosynthetic process / orotate phosphoribosyltransferase / orotate phosphoribosyltransferase activity / pyrimidine nucleobase biosynthetic process / Pyrimidine biosynthesis / orotidine-5'-phosphate decarboxylase / orotidine-5'-phosphate decarboxylase activity / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / lactation / female pregnancy / cellular response to xenobiotic stimulus / identical protein binding / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Orotate phosphoribosyl transferase domain / Orotate phosphoribosyltransferase / Purine/pyrimidine phosphoribosyl transferases signature. / Orotidine 5'-phosphate decarboxylase / Orotidine 5'-phosphate decarboxylase, active site / Orotidine 5'-phosphate decarboxylase active site. / Orotidine 5'-phosphate decarboxylase domain / Orotidine 5'-phosphate decarboxylase / HUMPS family / Orotidine 5'-phosphate decarboxylase / HUMPS family / Phosphoribosyl transferase domain ...Orotate phosphoribosyl transferase domain / Orotate phosphoribosyltransferase / Purine/pyrimidine phosphoribosyl transferases signature. / Orotidine 5'-phosphate decarboxylase / Orotidine 5'-phosphate decarboxylase, active site / Orotidine 5'-phosphate decarboxylase active site. / Orotidine 5'-phosphate decarboxylase domain / Orotidine 5'-phosphate decarboxylase / HUMPS family / Orotidine 5'-phosphate decarboxylase / HUMPS family / Phosphoribosyl transferase domain / Phosphoribosyltransferase-like / Phosphoribosyltransferase domain / Ribulose-phosphate binding barrel / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel / Alpha-Beta Barrel / Alpha Beta類似検索 - ドメイン・相同性 N-hydroxycytidine 5'-(dihydrogen phosphate) / 5-hydroxycytidine 5'-(dihydrogen phosphate) / Uridine 5'-monophosphate synthase類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 1.75 Å |
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データ登録者 | To, T.K. / Kotra, L.P. / Pai, E.F. |
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引用 | ジャーナル: J.Med.Chem. / 年: 2012 タイトル: Novel cytidine-based orotidine-5'-monophosphate decarboxylase inhibitors with an unusual twist. 著者: Purohit, M.K. / Poduch, E. / Wei, L.W. / Crandall, I.E. / To, T. / Kain, K.C. / Pai, E.F. / Kotra, L.P. |
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履歴 | 登録 | 2012年10月15日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2012年11月14日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2012年12月19日 | Group: Database references |
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改定 2.0 | 2021年8月4日 | Group: Atomic model / Data collection ...Atomic model / Data collection / Database references / Derived calculations カテゴリ: atom_site / chem_comp ...atom_site / chem_comp / struct_ref_seq_dif / struct_site Item: _atom_site.auth_atom_id / _atom_site.label_atom_id ..._atom_site.auth_atom_id / _atom_site.label_atom_id / _chem_comp.mon_nstd_flag / _chem_comp.type / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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改定 2.1 | 2024年2月28日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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