登録情報 データベース : PDB / ID : 4dkl 構造の表示 ダウンロードとリンクタイトル Crystal structure of the mu-opioid receptor bound to a morphinan antagonist 要素Mu-type opioid receptor, lysozyme chimera 詳細 キーワード SIGNALING PROTEIN/ANTAGONIST / G-protein coupled receptor / 7 transmembrane receptor / SIGNALING PROTEIN-ANTAGONIST complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Opioid Signalling / spine apparatus / beta-endorphin receptor activity / morphine receptor activity / negative regulation of Wnt protein secretion / Peptide ligand-binding receptors / adenylate cyclase-inhibiting opioid receptor signaling pathway / positive regulation of appetite / G-protein activation / G protein-coupled opioid receptor activity ... Opioid Signalling / spine apparatus / beta-endorphin receptor activity / morphine receptor activity / negative regulation of Wnt protein secretion / Peptide ligand-binding receptors / adenylate cyclase-inhibiting opioid receptor signaling pathway / positive regulation of appetite / G-protein activation / G protein-coupled opioid receptor activity / negative regulation of luteinizing hormone secretion / G protein-coupled opioid receptor signaling pathway / sperm ejaculation / G alpha (i) signalling events / adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway / negative regulation of nitric oxide biosynthetic process / negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway / neuropeptide binding / negative regulation of cAMP-mediated signaling / regulation of NMDA receptor activity / positive regulation of neurogenesis / eating behavior / negative regulation of cytosolic calcium ion concentration / transmission of nerve impulse / social behavior / G-protein alpha-subunit binding / GABA-ergic synapse / voltage-gated calcium channel activity / neuropeptide signaling pathway / viral release from host cell by cytolysis / positive regulation of gluconeogenesis / sensory perception of pain / dendrite membrane / presynaptic modulation of chemical synaptic transmission / adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway / excitatory postsynaptic potential / dendrite cytoplasm / peptidoglycan catabolic process / locomotory behavior / G protein-coupled receptor activity / adenylate cyclase-activating dopamine receptor signaling pathway / G-protein beta-subunit binding / cell wall macromolecule catabolic process / lysozyme / lysozyme activity / presynaptic membrane / phospholipase C-activating G protein-coupled receptor signaling pathway / postsynaptic membrane / perikaryon / response to ethanol / host cell cytoplasm / positive regulation of ERK1 and ERK2 cascade / endosome / defense response to bacterium / neuron projection / G protein-coupled receptor signaling pathway / protein domain specific binding / axon / focal adhesion / dendrite / membrane / plasma membrane 類似検索 - 分子機能 Mu opioid receptor / Opioid receptor / Rhopdopsin 7-helix transmembrane proteins / Rhodopsin 7-helix transmembrane proteins / Lysozyme - #40 / Endolysin T4 type / T4-type lysozyme / Glycoside hydrolase, family 24 / Lysozyme domain superfamily / Phage lysozyme ... Mu opioid receptor / Opioid receptor / Rhopdopsin 7-helix transmembrane proteins / Rhodopsin 7-helix transmembrane proteins / Lysozyme - #40 / Endolysin T4 type / T4-type lysozyme / Glycoside hydrolase, family 24 / Lysozyme domain superfamily / Phage lysozyme / Lysozyme / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family) / Lysozyme-like domain superfamily / Up-down Bundle / Orthogonal Bundle / Mainly Alpha 類似検索 - ドメイン・相同性 Chem-BF0 / CHOLESTEROL / Chem-MPG / Endolysin / Mu-type opioid receptor 類似検索 - 構成要素生物種 Mus musculus (ハツカネズミ) Enterobacteria phage T4 (ファージ)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.8 Å 詳細データ登録者 Manglik, A. / Kruse, A.C. / Kobilka, T.S. / Thian, F.S. / Mathiesen, J.M. / Sunahara, R.K. / Pardo, L. / Weis, W.I. / Kobilka, B.K. / Granier, S. 引用ジャーナル : Nature / 年 : 2012タイトル : Crystal structure of the {mu}-opioid receptor bound to a morphinan antagonist.著者 : Manglik, A. / Kruse, A.C. / Kobilka, T.S. / Thian, F.S. / Mathiesen, J.M. / Sunahara, R.K. / Pardo, L. / Weis, W.I. / Kobilka, B.K. / Granier, S. 履歴 登録 2012年2月3日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2012年3月21日 Provider : repository / タイプ : Initial release改定 1.1 2012年5月16日 Group : Database references改定 1.2 2016年6月8日 Group : Atomic model改定 1.3 2017年7月26日 Group : Refinement description / Source and taxonomy / カテゴリ : entity_src_gen / software改定 1.4 2023年9月13日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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