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- EMDB-4322: 26S proteasome, s4 state -

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Basic information

Entry
Database: EMDB / ID: EMD-4322
Title26S proteasome, s4 stateProteasome
Map dataNone
Sample
  • Complex: 26S proteasomeProteasome
    • Protein or peptide: x 33 types
  • Ligand: x 4 types
Function / homology
Function and homology information


SAGA complex localization to transcription regulatory region / peroxisome fission / proteasome storage granule assembly / transcription export complex 2 / proteasome regulatory particle assembly / protein deneddylation / nonfunctional rRNA decay / maintenance of DNA trinucleotide repeats / filamentous growth / COP9 signalosome ...SAGA complex localization to transcription regulatory region / peroxisome fission / proteasome storage granule assembly / transcription export complex 2 / proteasome regulatory particle assembly / protein deneddylation / nonfunctional rRNA decay / maintenance of DNA trinucleotide repeats / filamentous growth / COP9 signalosome / proteasome regulatory particle / cytosolic proteasome complex / proteasome regulatory particle, lid subcomplex / proteasome-activating activity / protein-containing complex localization / mitochondrial fission / proteasome regulatory particle, base subcomplex / K48-linked polyubiquitin modification-dependent protein binding / proteasome core complex assembly / nuclear outer membrane-endoplasmic reticulum membrane network / Cross-presentation of soluble exogenous antigens (endosomes) / TNFR2 non-canonical NF-kB pathway / proteasomal ubiquitin-independent protein catabolic process / Ub-specific processing proteases / peptide catabolic process / proteasome binding / regulation of protein catabolic process / protein deubiquitination / proteasome storage granule / polyubiquitin modification-dependent protein binding / endopeptidase activator activity / proteasome assembly / proteasome endopeptidase complex / positive regulation of RNA polymerase II transcription preinitiation complex assembly / proteasome core complex, beta-subunit complex / proteasome core complex, alpha-subunit complex / threonine-type endopeptidase activity / enzyme regulator activity / mRNA export from nucleus / protein folding chaperone / : / Neutrophil degranulation / proteasome complex / ubiquitin binding / proteasomal protein catabolic process / nucleotide-excision repair / positive regulation of transcription elongation by RNA polymerase II / double-strand break repair via homologous recombination / positive regulation of protein catabolic process / metallopeptidase activity / protein-macromolecule adaptor activity / ubiquitin-dependent protein catabolic process / proteasome-mediated ubiquitin-dependent protein catabolic process / endopeptidase activity / ubiquitinyl hydrolase 1 / cysteine-type deubiquitinase activity / molecular adaptor activity / regulation of cell cycle / chromatin remodeling / protein domain specific binding / mRNA binding / ubiquitin protein ligase binding / structural molecule activity / endoplasmic reticulum membrane / endoplasmic reticulum / ATP hydrolysis activity / positive regulation of transcription by RNA polymerase II / mitochondrion / ATP binding / metal ion binding / nucleus / identical protein binding / cytosol / cytoplasm
Similarity search - Function
Rpn9, C-terminal helix / Rpn9 C-terminal helix / Proteasomal ubiquitin receptor Rpn13/ADRM1 / Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily / Rpn13/ADRM1, Pru domain / Proteasome complex subunit Rpn13, Pru domain / Pru (pleckstrin-like receptor for ubiquitin) domain profile. / 26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix / 26S proteasome non-ATPase regulatory subunit Rpn12 / 26S proteasome regulatory subunit, C-terminal ...Rpn9, C-terminal helix / Rpn9 C-terminal helix / Proteasomal ubiquitin receptor Rpn13/ADRM1 / Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily / Rpn13/ADRM1, Pru domain / Proteasome complex subunit Rpn13, Pru domain / Pru (pleckstrin-like receptor for ubiquitin) domain profile. / 26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix / 26S proteasome non-ATPase regulatory subunit Rpn12 / 26S proteasome regulatory subunit, C-terminal / Proteasome regulatory subunit C-terminal / DSS1/SEM1 / 26S proteasome regulatory subunit RPN5, C-terminal domain / : / DSS1/SEM1 family / 26S proteasome regulatory subunit RPN5 C-terminal domain / 26S proteasome subunit RPN2, N-terminal domain / DSS1_SEM1 / 26S proteasome regulatory subunit Rpn6, N-terminal / 6S proteasome subunit Rpn6, C-terminal helix domain / 26S proteasome regulatory subunit RPN6 N-terminal domain / 26S proteasome subunit RPN6 C-terminal helix domain / 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit / 26S Proteasome non-ATPase regulatory subunit 13 / 26S proteasome regulatory subunit RPN2, C-terminal / 26S proteasome regulatory subunit RPN2 C-terminal domain / 26S Proteasome non-ATPase regulatory subunit 7/8 / Proteasome subunit Rpn10 / : / 26S proteasome regulatory subunit 7, OB domain / 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit / RPN1, N-terminal / 26S proteasome non-ATPase regulatory subunit RPN1, C-terminal / RPN1 N-terminal domain / 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal / 26S proteasome regulatory subunit Rpn7, N-terminal / 26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 / 26S proteasome subunit RPN7 / 26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 / Proteasome/cyclosome repeat / Proteasome/cyclosome repeat / PCI/PINT associated module / von Willebrand factor type A domain / CSN8/PSMD8/EIF3K / CSN8/PSMD8/EIF3K family / HEAT repeats / Rpn11/EIF3F, C-terminal / Maintenance of mitochondrial structure and function / Proteasomal ATPase OB C-terminal domain / Proteasomal ATPase OB C-terminal domain / motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 / PCI domain / Proteasome component (PCI) domain / PCI domain profile. / Ubiquitin interacting motif / Ubiquitin-interacting motif (UIM) domain profile. / JAB1/Mov34/MPN/PAD-1 ubiquitin protease / Proteasome beta subunit, C-terminal / Proteasome beta subunits C terminal / Proteasome subunit beta 4 / Proteasome subunit beta 2 / Proteasome beta 3 subunit / Proteasome subunit alpha6 / Proteasome subunit alpha5 / Proteasome beta-type subunits signature. / Peptidase T1A, proteasome beta-subunit / Proteasome beta-type subunit, conserved site / Proteasome subunit A N-terminal signature / Proteasome alpha-type subunits signature. / Proteasome alpha-subunit, N-terminal domain / Proteasome subunit A N-terminal signature Add an annotation / Proteasome alpha-type subunit / Proteasome alpha-type subunit profile. / Proteasome B-type subunit / Proteasome beta-type subunit profile. / VWFA domain profile. / Proteasome subunit / Proteasome, subunit alpha/beta / von Willebrand factor, type A / AAA ATPase, AAA+ lid domain / AAA+ lid domain / TPR repeat region circular profile. / ATPase, AAA-type, conserved site / AAA-protein family signature. / JAB/MPN domain / JAB1/MPN/MOV34 metalloenzyme domain / TPR repeat profile. / MPN domain / MPN domain profile. / Nucleophile aminohydrolases, N-terminal / von Willebrand factor A-like domain superfamily / Tetratricopeptide repeat / ATPase family associated with various cellular activities (AAA) / ATPase, AAA-type, core / Armadillo-like helical / Tetratricopeptide-like helical domain superfamily / Armadillo-type fold / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / ATPases associated with a variety of cellular activities
Similarity search - Domain/homology
26S proteasome regulatory subunit RPN13 / 26S proteasome complex subunit SEM1 / Probable proteasome subunit alpha type-7 / Proteasome subunit alpha type-1 / Proteasome subunit beta type-4 / Proteasome subunit alpha type-3 / Proteasome subunit alpha type-2 / Proteasome subunit beta type-6 / Proteasome subunit beta type-2 / Proteasome subunit beta type-3 ...26S proteasome regulatory subunit RPN13 / 26S proteasome complex subunit SEM1 / Probable proteasome subunit alpha type-7 / Proteasome subunit alpha type-1 / Proteasome subunit beta type-4 / Proteasome subunit alpha type-3 / Proteasome subunit alpha type-2 / Proteasome subunit beta type-6 / Proteasome subunit beta type-2 / Proteasome subunit beta type-3 / Proteasome subunit beta type-5 / Proteasome subunit beta type-7 / Proteasome subunit alpha type-5 / 26S proteasome regulatory subunit RPN12 / 26S proteasome regulatory subunit RPN2 / 26S proteasome regulatory subunit 6A / 26S proteasome regulatory subunit 6B homolog / 26S proteasome regulatory subunit 7 homolog / Proteasome subunit beta type-1 / 26S proteasome regulatory subunit RPN1 / 26S proteasome regulatory subunit RPN10 / 26S proteasome regulatory subunit RPN3 / Proteasome subunit alpha type-6 / Proteasome subunit alpha type-4 / 26S proteasome regulatory subunit 4 homolog / Ubiquitin carboxyl-terminal hydrolase RPN11 / 26S proteasome subunit RPT4 / 26S proteasome regulatory subunit 8 homolog / 26S proteasome regulatory subunit RPN9 / 26S proteasome regulatory subunit RPN7 / 26S proteasome regulatory subunit RPN8 / 26S proteasome regulatory subunit RPN5 / 26S proteasome regulatory subunit RPN6
Similarity search - Component
Biological speciesSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast) / Baker's yeast (brewer's yeast)
Methodsingle particle reconstruction / cryo EM / Resolution: 4.5 Å
AuthorsEisele MR / Reed RG / Rudack T / Schweitzer A / Beck F / Nagy I / Pfeifer G / Plitzko JM / Baumeister W / Tomko RJ / Sakata E
CitationJournal: Cell Rep / Year: 2018
Title: Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating.
Authors: Markus R Eisele / Randi G Reed / Till Rudack / Andreas Schweitzer / Florian Beck / Istvan Nagy / Günter Pfeifer / Jürgen M Plitzko / Wolfgang Baumeister / Robert J Tomko / Eri Sakata /
Abstract: The proteasome is the central protease for intracellular protein breakdown. Coordinated binding and hydrolysis of ATP by the six proteasomal ATPase subunits induces conformational changes that drive ...The proteasome is the central protease for intracellular protein breakdown. Coordinated binding and hydrolysis of ATP by the six proteasomal ATPase subunits induces conformational changes that drive the unfolding and translocation of substrates into the proteolytic 20S core particle for degradation. Here, we combine genetic and biochemical approaches with cryo-electron microscopy and integrative modeling to dissect the relationship between individual nucleotide binding events and proteasome conformational dynamics. We demonstrate unique impacts of ATP binding by individual ATPases on the proteasome conformational distribution and report two conformational states of the proteasome suggestive of a rotary ATP hydrolysis mechanism. These structures, coupled with functional analyses, reveal key roles for the ATPases Rpt1 and Rpt6 in gating substrate entry into the core particle. This deepened knowledge of proteasome conformational dynamics reveals key elements of intersubunit communication within the proteasome and clarifies the regulation of substrate entry into the proteolytic chamber.
History
DepositionMar 5, 2018-
Header (metadata) releaseMay 30, 2018-
Map releaseAug 29, 2018-
UpdateNov 25, 2020-
Current statusNov 25, 2020Processing site: PDBe / Status: Released

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Structure visualization

Movie
  • Surface view with section colored by density value
  • Surface level: 0.025
  • Imaged by UCSF Chimera
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  • Surface view colored by radius
  • Surface level: 0.025
  • Imaged by UCSF Chimera
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  • Surface view with fitted model
  • Atomic models: PDB-6fvw
  • Surface level: 0.025
  • Imaged by UCSF Chimera
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Movie viewer
Structure viewerEM map:
SurfViewMolmilJmol/JSmol
Supplemental images

Downloads & links

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Map

FileDownload / File: emd_4322.map.gz / Format: CCP4 / Size: 216 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
AnnotationNone
Voxel sizeX=Y=Z: 1.38 Å
Density
Contour LevelBy AUTHOR: 0.02 / Movie #1: 0.025
Minimum - Maximum-0.1852349 - 0.22315976
Average (Standard dev.)0.00000408950 (±0.006767055)
SymmetrySpace group: 1
Details

EMDB XML:

Map geometry
Axis orderXYZ
Origin000
Dimensions384384384
Spacing384384384
CellA=B=C: 529.92 Å
α=β=γ: 90.0 °

CCP4 map header:

modeImage stored as Reals
Å/pix. X/Y/Z1.381.381.38
M x/y/z384384384
origin x/y/z0.0000.0000.000
length x/y/z529.920529.920529.920
α/β/γ90.00090.00090.000
MAP C/R/S123
start NC/NR/NS000
NC/NR/NS384384384
D min/max/mean-0.1850.2230.000

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Supplemental data

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Sample components

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Entire : 26S proteasome

EntireName: 26S proteasomeProteasome
Components
  • Complex: 26S proteasomeProteasome
    • Protein or peptide: Proteasome subunit alpha type-1
    • Protein or peptide: Proteasome subunit alpha type-2
    • Protein or peptide: Proteasome subunit alpha type-3
    • Protein or peptide: Proteasome subunit alpha type-4
    • Protein or peptide: Proteasome subunit alpha type-5
    • Protein or peptide: Proteasome subunit alpha type-6
    • Protein or peptide: Probable proteasome subunit alpha type-7
    • Protein or peptide: Proteasome subunit beta type-1PSMB1
    • Protein or peptide: Proteasome subunit beta type-2PSMB2
    • Protein or peptide: Proteasome subunit beta type-3PSMB3
    • Protein or peptide: Proteasome subunit beta type-4PSMB4
    • Protein or peptide: Proteasome subunit beta type-5PSMB5
    • Protein or peptide: Proteasome subunit beta type-6
    • Protein or peptide: Proteasome subunit beta type-7
    • Protein or peptide: 26S proteasome regulatory subunit RPN10
    • Protein or peptide: Ubiquitin carboxyl-terminal hydrolase RPN11
    • Protein or peptide: 26S proteasome regulatory subunit RPN12
    • Protein or peptide: 26S proteasome regulatory subunit RPN13
    • Protein or peptide: 26S proteasome complex subunit SEM1Proteasome
    • Protein or peptide: 26S proteasome regulatory subunit RPN1
    • Protein or peptide: 26S proteasome regulatory subunit RPN2
    • Protein or peptide: 26S proteasome regulatory subunit RPN3
    • Protein or peptide: 26S proteasome regulatory subunit RPN5
    • Protein or peptide: 26S proteasome regulatory subunit RPN6
    • Protein or peptide: 26S proteasome regulatory subunit RPN7
    • Protein or peptide: 26S proteasome regulatory subunit RPN8
    • Protein or peptide: 26S proteasome regulatory subunit RPN9
    • Protein or peptide: 26S proteasome regulatory subunit 7 homolog
    • Protein or peptide: 26S proteasome regulatory subunit 4 homolog
    • Protein or peptide: 26S proteasome regulatory subunit 6B homolog
    • Protein or peptide: 26S proteasome subunit RPT4Proteasome
    • Protein or peptide: 26S proteasome regulatory subunit 6A
    • Protein or peptide: 26S proteasome regulatory subunit 8 homolog
  • Ligand: ADENOSINE-5'-TRIPHOSPHATE
  • Ligand: MAGNESIUM ION
  • Ligand: ADENOSINE-5'-DIPHOSPHATE
  • Ligand: water

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Supramolecule #1: 26S proteasome

SupramoleculeName: 26S proteasome / type: complex / ID: 1 / Parent: 0 / Macromolecule list: #1-#33
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)

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Macromolecule #1: Proteasome subunit alpha type-1

MacromoleculeName: Proteasome subunit alpha type-1 / type: protein_or_peptide / ID: 1 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Baker's yeast (brewer's yeast)
Molecular weightTheoretical: 27.359104 KDa
SequenceString: SAAGYDRHIT IFSPEGRLYQ VEYAFKATNQ TNINSLAVRG KDCTVVISQK KVPDKLLDPT TVSYIFCISR TIGMVVNGPI PDARNAALR AKAEAAEFRY KYGYDMPCDV LAKRMANLSQ IYTQRAYMRP LGVILTFVSV DEELGPSIYK TDPAGYYVGY K ATATGPKQ ...String:
SAAGYDRHIT IFSPEGRLYQ VEYAFKATNQ TNINSLAVRG KDCTVVISQK KVPDKLLDPT TVSYIFCISR TIGMVVNGPI PDARNAALR AKAEAAEFRY KYGYDMPCDV LAKRMANLSQ IYTQRAYMRP LGVILTFVSV DEELGPSIYK TDPAGYYVGY K ATATGPKQ QEITTNLENH FKKSKIDHIN EESWEKVVEF AITHMIDALG TEFSKNDLEV GVATKDKFFT LSAENIEERL VA IAEQ

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Macromolecule #2: Proteasome subunit alpha type-2

MacromoleculeName: Proteasome subunit alpha type-2 / type: protein_or_peptide / ID: 2 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Baker's yeast (brewer's yeast)
Molecular weightTheoretical: 26.844439 KDa
SequenceString: RYSFSLTTFS PSGKLGQIDY ALTAVKQGVT SLGIKATNGV VIATEKKSSS PLAMSETLSK VSLLTPDIGA VYSGMGPDYR VLVDKSRKV AHTSYKRIYG EYPPTKLLVS EVAKIMQEAT QSGGVRPFGV SLLIAGHDEF NGFSLYQVDP SGSYFPWKAT A IGKGSVAA ...String:
RYSFSLTTFS PSGKLGQIDY ALTAVKQGVT SLGIKATNGV VIATEKKSSS PLAMSETLSK VSLLTPDIGA VYSGMGPDYR VLVDKSRKV AHTSYKRIYG EYPPTKLLVS EVAKIMQEAT QSGGVRPFGV SLLIAGHDEF NGFSLYQVDP SGSYFPWKAT A IGKGSVAA KTFLEKRWND ELELEDAIHI ALLTLKESVE GEFNGDTIEL AIIGDENPDL LGYTGIPTDK GPRFRKLTSQ EI NDRLEAL

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Macromolecule #3: Proteasome subunit alpha type-3

MacromoleculeName: Proteasome subunit alpha type-3 / type: protein_or_peptide / ID: 3 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Baker's yeast (brewer's yeast)
Molecular weightTheoretical: 26.74909 KDa
SequenceString: RYDSRTTIFS PEGRLYQVEY ALESISHAGT AIGIMASDGI VLAAERKVTS TLLEQDTSTE KLYKLNDKIA VAVAGLTADA EILINTARI HAQNYLKTYN EDIPVEILVR RLSDIKQGYT QHGGLRPFGV SFIYAGYDDR YGYQLYTSNP SGNYTGWKAI S VGANTSAA ...String:
RYDSRTTIFS PEGRLYQVEY ALESISHAGT AIGIMASDGI VLAAERKVTS TLLEQDTSTE KLYKLNDKIA VAVAGLTADA EILINTARI HAQNYLKTYN EDIPVEILVR RLSDIKQGYT QHGGLRPFGV SFIYAGYDDR YGYQLYTSNP SGNYTGWKAI S VGANTSAA QTLLQMDYKD DMKVDDAIEL ALKTLSKTTD SSALTYDRLE FATIRKGAND GEVYQKIFKP QEIKDILVKT GI T

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Macromolecule #4: Proteasome subunit alpha type-4

MacromoleculeName: Proteasome subunit alpha type-4 / type: protein_or_peptide / ID: 4 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Baker's yeast (brewer's yeast)
Molecular weightTheoretical: 28.259838 KDa
SequenceString: GYDRALSIFS PDGHIFQVEY ALEAVKRGTC AVGVKGKNCV VLGCERRSTL KLQDTRITPS KVSKIDSHVV LSFSGLNADS RILIEKARV EAQSHRLTLE DPVTVEYLTR YVAGVQQRYT QSGGVRPFGV STLIAGFDPR DDEPKLYQTE PSGIYSSWSA Q TIGRNSKT ...String:
GYDRALSIFS PDGHIFQVEY ALEAVKRGTC AVGVKGKNCV VLGCERRSTL KLQDTRITPS KVSKIDSHVV LSFSGLNADS RILIEKARV EAQSHRLTLE DPVTVEYLTR YVAGVQQRYT QSGGVRPFGV STLIAGFDPR DDEPKLYQTE PSGIYSSWSA Q TIGRNSKT VREFLEKNYD RKEPPATVEE CVKLTVRSLL EVVQTGAKNI EITVVKPDSD IVALSSEEIN QYVTQIEQEK QE QQEQDKK KKSNH

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Macromolecule #5: Proteasome subunit alpha type-5

MacromoleculeName: Proteasome subunit alpha type-5 / type: protein_or_peptide / ID: 5 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Baker's yeast (brewer's yeast)
Molecular weightTheoretical: 26.924156 KDa
SequenceString: SEYDRGVSTF SPEGRLFQVE YSLEAIKLGS TAIGIATKEG VVLGVEKRAT SPLLESDSIE KIVEIDRHIG CAMSGLTADA RSMIEHART AAVTHNLYYD EDINVESLTQ SVCDLALRFG EGASGEERLM SRPFGVALLI AGHDADDGYQ LFHAEPSGTF Y RYNAKAIG ...String:
SEYDRGVSTF SPEGRLFQVE YSLEAIKLGS TAIGIATKEG VVLGVEKRAT SPLLESDSIE KIVEIDRHIG CAMSGLTADA RSMIEHART AAVTHNLYYD EDINVESLTQ SVCDLALRFG EGASGEERLM SRPFGVALLI AGHDADDGYQ LFHAEPSGTF Y RYNAKAIG SGSEGAQAEL LNEWHSSLTL KEAELLVLKI LKQVMEEKLD ENNAQLSCIT KQDGFKIYDN EKTAELIKEL KE KEAAE

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Macromolecule #6: Proteasome subunit alpha type-6

MacromoleculeName: Proteasome subunit alpha type-6 / type: protein_or_peptide / ID: 6 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Baker's yeast (brewer's yeast)
Molecular weightTheoretical: 25.355631 KDa
SequenceString: RNNYDGDTVT FSPTGRLFQV EYALEAIKQG SVTVGLRSNT HAVLVALKRN ADELSSYQKK IIKCDEHMGL SLAGLAPDAR VLSNYLRQQ CNYSSLVFNR KLAVERAGHL LCDKAQKNTQ SYGGRPYGVG LLIIGYDKSG AHLLEFQPSG NVTELYGTAI G ARSQGAKT ...String:
RNNYDGDTVT FSPTGRLFQV EYALEAIKQG SVTVGLRSNT HAVLVALKRN ADELSSYQKK IIKCDEHMGL SLAGLAPDAR VLSNYLRQQ CNYSSLVFNR KLAVERAGHL LCDKAQKNTQ SYGGRPYGVG LLIIGYDKSG AHLLEFQPSG NVTELYGTAI G ARSQGAKT YLERTLDTFI KIDGNPDELI KAGVEAISQS LRDESLTVDN LSIAIVGKDT PFTIYDGEAV AKYI

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Macromolecule #7: Probable proteasome subunit alpha type-7

MacromoleculeName: Probable proteasome subunit alpha type-7 / type: protein_or_peptide / ID: 7 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 27.005641 KDa
SequenceString: IGTGYDLSNS VFSPDGRNFQ VEYAVKAVEN GTTSIGIKCN DGVVFAVEKL ITSKLLVPQK NVKIQVVDRH IGCVYSGLIP DGRHLVNRG REEAASFKKL YKTPIPIPAF ADRLGQYVQA HTLYNSVRPF GVSTIFGGVD KNGAHLYMLE PSGSYWGYKG A ATGKGRQS ...String:
IGTGYDLSNS VFSPDGRNFQ VEYAVKAVEN GTTSIGIKCN DGVVFAVEKL ITSKLLVPQK NVKIQVVDRH IGCVYSGLIP DGRHLVNRG REEAASFKKL YKTPIPIPAF ADRLGQYVQA HTLYNSVRPF GVSTIFGGVD KNGAHLYMLE PSGSYWGYKG A ATGKGRQS AKAELEKLVD HHPEGLSARE AVKQAAKIIY LAHEDNKEKD FELEISWCSL SETNGLHKFV KGDLLQEAID FA QKEIN

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Macromolecule #8: Proteasome subunit beta type-1

MacromoleculeName: Proteasome subunit beta type-1 / type: protein_or_peptide / ID: 8 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 21.517186 KDa
SequenceString: TSIMAVTFKD GVILGADSRT TTGAYIANRV TDKLTRVHDK IWCCRSGSAA DTQAIADIVQ YHLELYTSQY GTPSTETAAS VFKELCYEN KDNLTAGIIV AGYDDKNKGE VYTIPLGGSV HKLPYAIAGS GSTFIYGYCD KNFRENMSKE ETVDFIKHSL S QAIKWDGS ...String:
TSIMAVTFKD GVILGADSRT TTGAYIANRV TDKLTRVHDK IWCCRSGSAA DTQAIADIVQ YHLELYTSQY GTPSTETAAS VFKELCYEN KDNLTAGIIV AGYDDKNKGE VYTIPLGGSV HKLPYAIAGS GSTFIYGYCD KNFRENMSKE ETVDFIKHSL S QAIKWDGS SGGVIRMVVL TAAGVERLIF YPDEYEQL

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Macromolecule #9: Proteasome subunit beta type-2

MacromoleculeName: Proteasome subunit beta type-2 / type: protein_or_peptide / ID: 9 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 24.48677 KDa
SequenceString: TTIVGVKFNN GVVIAADTRS TQGPIVADKN CAKLHRISPK IWCAGAGTAA DTEAVTQLIG SNIELHSLYT SREPRVVSAL QMLKQHLFK YQGHIGAYLI VAGVDPTGSH LFSIHAHGST DVGYYLSLGS GSLAAMAVLE SHWKQDLTKE EAIKLASDAI Q AGIWNDLG ...String:
TTIVGVKFNN GVVIAADTRS TQGPIVADKN CAKLHRISPK IWCAGAGTAA DTEAVTQLIG SNIELHSLYT SREPRVVSAL QMLKQHLFK YQGHIGAYLI VAGVDPTGSH LFSIHAHGST DVGYYLSLGS GSLAAMAVLE SHWKQDLTKE EAIKLASDAI Q AGIWNDLG SGSNVDVCVM EIGKDAEYLR NYLTPNVREE KQKSYKFPRG TTAVLKESIV NICDIQEE

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Macromolecule #10: Proteasome subunit beta type-3

MacromoleculeName: Proteasome subunit beta type-3 / type: protein_or_peptide / ID: 10 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 22.496645 KDa
SequenceString: SDPSSINGGI VVAMTGKDCV AIACDLRLGS QSLGVSNKFE KIFHYGHVFL GITGLATDVT TLNEMFRYKT NLYKLKEERA IEPETFTQL VSSSLYERRF GPYFVGPVVA GINSKSGKPF IAGFDLIGCI DEAKDFIVSG TASDQLFGMC ESLYEPNLEP E DLFETISQ ...String:
SDPSSINGGI VVAMTGKDCV AIACDLRLGS QSLGVSNKFE KIFHYGHVFL GITGLATDVT TLNEMFRYKT NLYKLKEERA IEPETFTQL VSSSLYERRF GPYFVGPVVA GINSKSGKPF IAGFDLIGCI DEAKDFIVSG TASDQLFGMC ESLYEPNLEP E DLFETISQ ALLNAADRDA LSGWGAVVYI IKKDEVVKRY LKMRQD

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Macromolecule #11: Proteasome subunit beta type-4

MacromoleculeName: Proteasome subunit beta type-4 / type: protein_or_peptide / ID: 11 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 22.218338 KDa
SequenceString: MDIILGIRVQ DSVILASSKA VTRGISVLKD SDDKTRQLSP HTLMSFAGEA GDTVQFAEYI QANIQLYSIR EDYELSPQAV SSFVRQELA KSIRSRRPYQ VNVLIGGYDK KKNKPELYQI DYLGTKVELP YGAHGYSGFY TFSLLDHHYR PDMTTEEGLD L LKLCVQEL ...String:
MDIILGIRVQ DSVILASSKA VTRGISVLKD SDDKTRQLSP HTLMSFAGEA GDTVQFAEYI QANIQLYSIR EDYELSPQAV SSFVRQELA KSIRSRRPYQ VNVLIGGYDK KKNKPELYQI DYLGTKVELP YGAHGYSGFY TFSLLDHHYR PDMTTEEGLD L LKLCVQEL EKRMPMDFKG VIVKIVDKDG IRQVDDF

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Macromolecule #12: Proteasome subunit beta type-5

MacromoleculeName: Proteasome subunit beta type-5 / type: protein_or_peptide / ID: 12 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 23.325248 KDa
SequenceString: TTTLAFRFQG GIIVAVDSRA TAGNWVASQT VKKVIEINPF LLGTMAGGAA DCQFWETWLG SQCRLHELRE KERISVAAAS KILSNLVYQ YKGAGLSMGT MICGYTRKEG PTIYYVDSDG TRLKGDIFCV GSGQTFAYGV LDSNYKWDLS VEDALYLGKR S ILAAAHRD ...String:
TTTLAFRFQG GIIVAVDSRA TAGNWVASQT VKKVIEINPF LLGTMAGGAA DCQFWETWLG SQCRLHELRE KERISVAAAS KILSNLVYQ YKGAGLSMGT MICGYTRKEG PTIYYVDSDG TRLKGDIFCV GSGQTFAYGV LDSNYKWDLS VEDALYLGKR S ILAAAHRD AYSGGSVNLY HVTEDGWIYH GNHDVGELFW KVKEEEGSFN NVIG

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Macromolecule #13: Proteasome subunit beta type-6

MacromoleculeName: Proteasome subunit beta type-6 / type: protein_or_peptide / ID: 13 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 24.883928 KDa
SequenceString: QFNPYGDNGG TILGIAGEDF AVLAGDTRNI TDYSINSRYE PKVFDCGDNI VMSANGFAAD GDALVKRFKN SVKWYHFDHN DKKLSINSA ARNIQHLLYG KRFFPYYVHT IIAGLDEDGK GAVYSFDPVG SYEREQCRAG GAAASLIMPF LDNQVNFKNQ Y EPGTNGKV ...String:
QFNPYGDNGG TILGIAGEDF AVLAGDTRNI TDYSINSRYE PKVFDCGDNI VMSANGFAAD GDALVKRFKN SVKWYHFDHN DKKLSINSA ARNIQHLLYG KRFFPYYVHT IIAGLDEDGK GAVYSFDPVG SYEREQCRAG GAAASLIMPF LDNQVNFKNQ Y EPGTNGKV KKPLKYLSVE EVIKLVRDSF TSATERHIQV GDGLEILIVT KDGVRKEFYE LKRD

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Macromolecule #14: Proteasome subunit beta type-7

MacromoleculeName: Proteasome subunit beta type-7 / type: protein_or_peptide / ID: 14 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 25.832336 KDa
SequenceString: TQQPIVTGTS VISMKYDNGV IIAADNLGSY GSLLRFNGVE RLIPVGDNTV VGISGDISDM QHIERLLKDL VTENAYDNPL ADAEEALEP SYIFEYLATV MYQRRSKMNP LWNAIIVAGV QSNGDQFLRY VNLLGVTYSS PTLATGFGAH MANPLLRKVV D RESDIPKT ...String:
TQQPIVTGTS VISMKYDNGV IIAADNLGSY GSLLRFNGVE RLIPVGDNTV VGISGDISDM QHIERLLKDL VTENAYDNPL ADAEEALEP SYIFEYLATV MYQRRSKMNP LWNAIIVAGV QSNGDQFLRY VNLLGVTYSS PTLATGFGAH MANPLLRKVV D RESDIPKT TVQVAEEAIV NAMRVLYYRD ARSSRNFSLA IIDKNTGLTF KKNLQVENMK WDFAKDIKGY GTQK

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Macromolecule #15: 26S proteasome regulatory subunit RPN10

MacromoleculeName: 26S proteasome regulatory subunit RPN10 / type: protein_or_peptide / ID: 15 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 21.818613 KDa
SequenceString: MVLEATVLVI DNSEYSRNGD FPRTRFEAQI DSVEFIFQAK RNSNPENTVG LISGAGANPR VLSTFTAEFG KILAGLHDTQ IEGKLHMAT ALQIAQLTLK HRQNKVQHQR IVAFVCSPIS DSRDELIRLA KTLKKNNVAV DIINFGEIEQ NTELLDEFIA A VNNPQEET ...String:
MVLEATVLVI DNSEYSRNGD FPRTRFEAQI DSVEFIFQAK RNSNPENTVG LISGAGANPR VLSTFTAEFG KILAGLHDTQ IEGKLHMAT ALQIAQLTLK HRQNKVQHQR IVAFVCSPIS DSRDELIRLA KTLKKNNVAV DIINFGEIEQ NTELLDEFIA A VNNPQEET SHLLTVTPGP RLLYENIASS PIILEEGSS

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Macromolecule #16: Ubiquitin carboxyl-terminal hydrolase RPN11

MacromoleculeName: Ubiquitin carboxyl-terminal hydrolase RPN11 / type: protein_or_peptide / ID: 16 / Number of copies: 1 / Enantiomer: LEVO / EC number: ubiquitinyl hydrolase 1
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 32.490963 KDa
SequenceString: TGRDDTKETV YISSIALLKM LKHGRAGVPM EVMGLMLGEF VDDYTVNVVD VFAMPQSGTG VSVEAVDDVF QAKMMDMLKQ TGRDQMVVG WYHSHPGFGC WLSSVDVNTQ KSFEQLNSRA VAVVVDPIQS VKGKVVIDAF RLIDTGALIN NLEPRQTTSN T GLLNKANI ...String:
TGRDDTKETV YISSIALLKM LKHGRAGVPM EVMGLMLGEF VDDYTVNVVD VFAMPQSGTG VSVEAVDDVF QAKMMDMLKQ TGRDQMVVG WYHSHPGFGC WLSSVDVNTQ KSFEQLNSRA VAVVVDPIQS VKGKVVIDAF RLIDTGALIN NLEPRQTTSN T GLLNKANI QALIHGLNRH YYSLNIDYHK TAKETKMLMN LHKEQWQSGL KMYDYEEKEE SNLAATKSMV KIAEQYSKRI EE EKELTEE ELKTRYVGRQ DPKKHLSETA DETLENNIVS VLTAGVNSVA IK

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Macromolecule #17: 26S proteasome regulatory subunit RPN12

MacromoleculeName: 26S proteasome regulatory subunit RPN12 / type: protein_or_peptide / ID: 17 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 31.111098 KDa
SequenceString: LTKSLSIAFE NGDYAACEKL LPPIKIELIK NNLLIPDLSI QNDIYLNDLM ITKRILEVGA LASIQTFNFD SFENYFNQLK PYYFSNNHK LSESDKKSKL ISLYLLNLLS QNNTTKFHSE LQYLDKHIKN LEDDSLLSYP IKLDRWLMEG SYQKAWDLLQ S GSQNISEF ...String:
LTKSLSIAFE NGDYAACEKL LPPIKIELIK NNLLIPDLSI QNDIYLNDLM ITKRILEVGA LASIQTFNFD SFENYFNQLK PYYFSNNHK LSESDKKSKL ISLYLLNLLS QNNTTKFHSE LQYLDKHIKN LEDDSLLSYP IKLDRWLMEG SYQKAWDLLQ S GSQNISEF DSFTDILKSA IRDEIAKNTE LSYDFLPLSN IKALLFFNNE KETEKFALER NWPIVNSKVY FNNQSKEKAD YE DEMMHEE DQKTNIIEKA MDYAISIEN

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Macromolecule #18: 26S proteasome regulatory subunit RPN13

MacromoleculeName: 26S proteasome regulatory subunit RPN13 / type: protein_or_peptide / ID: 18 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 14.654642 KDa
SequenceString:
VIKFRAGVCE YNEDSRLCTP IPVQGEIEIK PNEEEELGFW DFEWRPTEKP VGRELDPISL ILIPGETMWV PIKSSKSGRI FALVFSSNE RYFFWLQEKN SGNLPLNELS AKDKEIYNKM IGVLNNSS

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Macromolecule #19: 26S proteasome complex subunit SEM1

MacromoleculeName: 26S proteasome complex subunit SEM1 / type: protein_or_peptide / ID: 19 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 10.397102 KDa
SequenceString:
MSTDVAAAQA QSKIDLTKKK NEEINKKSLE EDDEFEDFPI DTWANGETIK SNAVTQTNIW EENWDDVEVD DDFTNELKAE LDRYKRENQ

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Macromolecule #20: 26S proteasome regulatory subunit RPN1

MacromoleculeName: 26S proteasome regulatory subunit RPN1 / type: protein_or_peptide / ID: 20 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 106.895875 KDa
SequenceString: MVDESDKKQQ TIDEQSQISP EKQTPNKKDK KKEEEEQLSE EDAKLKTDLE LLVERLKEDD SSLYEASLNA LKESIKNSTS SMTAVPKPL KFLRPTYPDL CSIYDKWTDP NLKSSLADVL SILAMTYSEN GKHDSLRYRL LSDVSDFEGW GHEYIRHLAL E IGEVYNDQ ...String:
MVDESDKKQQ TIDEQSQISP EKQTPNKKDK KKEEEEQLSE EDAKLKTDLE LLVERLKEDD SSLYEASLNA LKESIKNSTS SMTAVPKPL KFLRPTYPDL CSIYDKWTDP NLKSSLADVL SILAMTYSEN GKHDSLRYRL LSDVSDFEGW GHEYIRHLAL E IGEVYNDQ VEKDAEDETS SDGSKSDGSA ATSGFEFSKE DTLRLCLDIV PYFLKHNGEE DAVDLLLEIE SIDKLPQFVD EN TFQRVCQ YMVACVPLLP PPEDVAFLKT AYSIYLSQNE LTDAIALAVR LGEEDMIRSV FDATSDPVMH KQLAYILAAQ KTS FEYEGV QDIIGNGKLS EHFLYLAKEL NLTGPKVPED IYKSHLDNSK SVFSSAGLDS AQQNLASSFV NGFLNLGYCN DKLI VDNDN WVYKTKGDGM TSAVASIGSI YQWNLDGLQQ LDKYLYVDEP EVKAGALLGI GISASGVHDG EVEPALLLLQ DYVTN PDTK ISSAAILGLG IAFAGSKNDE VLGLLLPIAA STDLPIETAA MASLALAHVF VGTCNGDITT SIMDNFLERT AIELKT DWV RFLALALGIL YMGQGEQVDD VLETISAIEH PMTSAIEVLV GSCAYTGTGD VLLIQDLLHR LTPKNVKGEE DADEEET AE GQTNSISDFL GEQVNEPTKN EEAEIEVDEM EVDAEGEEVE VKAEITEKKN GESLEGEEIK SEEKKGKSSD KDATTDGK N DDEEEEKEAG IVDELAYAVL GIALIALGED IGKEMSLRHF GHLMHYGNEH IRRMVPLAMG IVSVSDPQMK VFDTLTRFS HDADLEVSMN SIFAMGLCGA GTNNARLAQL LRQLASYYSR EQDALFITRL AQGLLHLGKG TMTMDVFNDA HVLNKVTLAS ILTTAVGLV SPSFMLKHHQ LFYMLNAGIR PKFILALNDE GEPIKVNVRV GQAVETVGQA GRPKKITGWI TQSTPVLLNH G ERAELETD EY

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Macromolecule #21: 26S proteasome regulatory subunit RPN2

MacromoleculeName: 26S proteasome regulatory subunit RPN2 / type: protein_or_peptide / ID: 21 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 101.894094 KDa
SequenceString: TTAAPLLALL RENQDSVKTY ALESINNVVD QLWSEISNEL PDIEALYDDD TFSDREMAAL IASKVYYNLG EYESAVKYAL AAKDRFDID EKSQFVETIV SKSIEMYVQE ASKQYTKDEQ FYTKDIIDPK LTSIFERMIE KCLKASELKL ALGIALEGYR L DIIESALK ...String:
TTAAPLLALL RENQDSVKTY ALESINNVVD QLWSEISNEL PDIEALYDDD TFSDREMAAL IASKVYYNLG EYESAVKYAL AAKDRFDID EKSQFVETIV SKSIEMYVQE ASKQYTKDEQ FYTKDIIDPK LTSIFERMIE KCLKASELKL ALGIALEGYR L DIIESALK SKLDQDSTSE NVKIINYLLT LAITTVTNSK FRSSILRKSF DFLMNMPNCD YLTLNKVVVN LNDAGLALQL FK KLKEEND EGLSAQIAFD LVSSASQQLL EILVTELTAQ GYDPALLNIL SGLPTCDYYN TFLLNNKNID IGLLNKSKSS LDG KFSLFH TAVSVANGFM HAGTTDNSFI KANLPWLGKA QNWAKFTATA SLGVIHKGNL LEGKKVMAPY LPGSRASSRF IKGG SLYGL GLIYAGFGRD TTDYLKNIIV ENSGTSGDED VDVLLHGASL GIGLAAMGSA NIEVYEALKE VLYNDSATSG EAAAL GMGL CMLGTGKPEA IHDMFTYSQE TQHGNITRGL AVGLALINYG RQELADDLIT KMLASDESLL RYGGAFTIAL AYAGTG NNS AVKRLLHVAV SDSNDDVRRA AVIALGFVLL RDYTTVPRIV QLLSKSHNAH VRCGTAFALG IACAGKGLQS AIDVLDP LT KDPVDFVRQA AMIALSMILI QQTEKLNPQV ADINKNFLSV ITNKHQEGLA KFGACVAQGI MNAGGRNVTI QLENADTG T LDTKSVVGLV MFSQFWYWFP LAHFLSLSFT PTTVIGIRGS DQAIPKFQMN CYAKEDAFSY PRMYEEASGK EVEKVATAV LSTTARAKAR AKKTKKEKGP NEEEKKKEHE EKEKERETNK KGIKETKEND EEFYKNKYSS KPYKVDNMTR ILPQQSRYIS FIKDDRFVP VRKFKGNNGV VVLRDREPKE PVALIETVRQ MKD

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Macromolecule #22: 26S proteasome regulatory subunit RPN3

MacromoleculeName: 26S proteasome regulatory subunit RPN3 / type: protein_or_peptide / ID: 22 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 55.378328 KDa
SequenceString: LHHSEKKYAE EDQVQELLKV LNEISKTTLT LDPRYIWRSL KDLSSLRNQE LLNAETLCFT VNVLYPDSSS FKKNLLKFIT SNHKSSVPG SAELRNSYPA SFYSVNTEKK TIEVTAEINC FMHLLVQLFL WDSKELEQLV EFNRKVVIPN LLCYYNLRSL N LINAKLWF ...String:
LHHSEKKYAE EDQVQELLKV LNEISKTTLT LDPRYIWRSL KDLSSLRNQE LLNAETLCFT VNVLYPDSSS FKKNLLKFIT SNHKSSVPG SAELRNSYPA SFYSVNTEKK TIEVTAEINC FMHLLVQLFL WDSKELEQLV EFNRKVVIPN LLCYYNLRSL N LINAKLWF YIYLSHETLA RSSEEINSDN QNIILRSTMM KFLKIASLKH DNETKAMLIN LILRDFLNNG EVDSASDFIS KL EYPHTDV SSSLEARYFF YLSKINAIQL DYSTANEYII AAIRKAPHNS KSLGFLQQSN KLHCCIQLLM GDIPELSFFH QSN MQKSLL PYYHLTKAVK LGDLKKFTST ITKYKQLLLK DDTYQLCVRL RSNVIKTGIR IISLTYKKIS LRDICLKLNL DSEQ TVEYM VSRAIRDGVI EAKINHEDGF IETTELLNIY DSEDPQQVFD ERIKFANQLH DEYLVSMRYP EDKKTQQNEK

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Macromolecule #23: 26S proteasome regulatory subunit RPN5

MacromoleculeName: 26S proteasome regulatory subunit RPN5 / type: protein_or_peptide / ID: 23 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 51.341758 KDa
SequenceString: MSRDAPIKAD KDYSQILKEE FPKIDSLAQN DCNSALDQLL VLEKKTRQAS DLASSKEVLA KIVDLLASRN KWDDLNEQLT LLSKKHGQL KLSIQYMIQK VMEYLKSSKS LDLNTRISVI ETIRVVTENK IFVEVERARV TKDLVEIKKE EGKIDEAADI L CELQVETY ...String:
MSRDAPIKAD KDYSQILKEE FPKIDSLAQN DCNSALDQLL VLEKKTRQAS DLASSKEVLA KIVDLLASRN KWDDLNEQLT LLSKKHGQL KLSIQYMIQK VMEYLKSSKS LDLNTRISVI ETIRVVTENK IFVEVERARV TKDLVEIKKE EGKIDEAADI L CELQVETY GSMEMSEKIQ FILEQMELSI LKGDYSQATV LSRKILKKTF KNPKYESLKL EYYNLLVKIS LHKREYLEVA QY LQEIYQT DAIKSDEAKW KPVLSHIVYF LVLSPYGNLQ NDLIHKIQND NNLKKLESQE SLVKLFTTNE LMRWPIVQKT YEP VLNEDD LAFGGEANKH HWEDLQKRVI EHNLRVISEY YSRITLLRLN ELLDLTESQT ETYISDLVNQ GIIYAKVNRP AKIV NFEKP KNSSQLLNEW SHNVDELLEH IETIGHLITK EEIMH

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Macromolecule #24: 26S proteasome regulatory subunit RPN6

MacromoleculeName: 26S proteasome regulatory subunit RPN6 / type: protein_or_peptide / ID: 24 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 49.839812 KDa
SequenceString: MSLPGSKLEE ARRLVNEKQY NEAEQVYLSL LDKDSSQSSA AAGASVDDKR RNEQETSILE LGQLYVTMGA KDKLREFIPH STEYMMQFA KSKTVKVLKT LIEKFEQVPD SLDDQIFVCE KSIEFAKREK RVFLKHSLSI KLATLHYQKK QYKDSLALIN D LLREFKKL ...String:
MSLPGSKLEE ARRLVNEKQY NEAEQVYLSL LDKDSSQSSA AAGASVDDKR RNEQETSILE LGQLYVTMGA KDKLREFIPH STEYMMQFA KSKTVKVLKT LIEKFEQVPD SLDDQIFVCE KSIEFAKREK RVFLKHSLSI KLATLHYQKK QYKDSLALIN D LLREFKKL DDKPSLVDVH LLESKVYHKL RNLAKSKASL TAARTAANSI YCPTQTVAEL DLMSGILHCE DKDYKTAFSY FF ESFESYH NLTTHNSYEK ACQVLKYMLL SKIMLNLIDD VKNILNAKYT KETYQSRGID AMKAVAEAYN NRSLLDFNTA LKQ YEKELM GDELTRSHFN ALYDTLLESN LCKIIEPFEC VEISHISKII GLDTQQVEGK LSQMILDKIF YGVLDQGNGW LYVY ETPNQ DATYDSALEL VGQLNKVVDQ LFEKASVLY

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Macromolecule #25: 26S proteasome regulatory subunit RPN7

MacromoleculeName: 26S proteasome regulatory subunit RPN7 / type: protein_or_peptide / ID: 25 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 46.307477 KDa
SequenceString: RVPNYEVSEK AFLLTQSKVS IEQRKEAAEF VLAKIKEEEM APYYKYLCEE YLVNNGQSDL EHDEKSDSLN EWIKFDQELY NELCKKNES KIKELNEKIQ KLEEDDEGEL EQAQAWINLG EYYAQIGDKD NAEKTLGKSL SKAISTGAKI DVMLTIARLG F FYNDQLYV ...String:
RVPNYEVSEK AFLLTQSKVS IEQRKEAAEF VLAKIKEEEM APYYKYLCEE YLVNNGQSDL EHDEKSDSLN EWIKFDQELY NELCKKNES KIKELNEKIQ KLEEDDEGEL EQAQAWINLG EYYAQIGDKD NAEKTLGKSL SKAISTGAKI DVMLTIARLG F FYNDQLYV KEKLEAVNSM IEKGGDWERR NRYKTYYGIH CLAVRNFKEA AKLLVDSLAT FTSIELTSYE SIATYASVTG LF TLERTDL KSKVIDSPEL LSLISTTAAL QSISSLTISL YASDYASYFP YLLETYANVL IPCKYLNRHA DFFVREMRRK VYA QLLESY KTLSLKSMAS AFGVSVAFLD NDLGKFIPNK QLNCVIDRVN GIVETNRPDN KNAQYHLLVK QGDGLLTKLQ KYGA AVRLT

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Macromolecule #26: 26S proteasome regulatory subunit RPN8

MacromoleculeName: 26S proteasome regulatory subunit RPN8 / type: protein_or_peptide / ID: 26 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 34.557316 KDa
SequenceString: MSLQHEKVTI APLVLLSALD HYERTQTKEN KRCVGVILGD ANSSTIRVTN SFALPFEEDE KNSDVWFLDH NYIENMNEMC KKINAKEKL IGWYHSGPKL RASDLKINEL FKKYTQNNPL LLIVDVKQQG VGLPTDAYVA IEQVKDDGTS TEKTFLHLPC T IEAEEAEE ...String:
MSLQHEKVTI APLVLLSALD HYERTQTKEN KRCVGVILGD ANSSTIRVTN SFALPFEEDE KNSDVWFLDH NYIENMNEMC KKINAKEKL IGWYHSGPKL RASDLKINEL FKKYTQNNPL LLIVDVKQQG VGLPTDAYVA IEQVKDDGTS TEKTFLHLPC T IEAEEAEE IGVEHLLRDV RDQAAGGLSI RLTNQLKSLK GLQSKLKDVV EYLDKVINKE LPINHTILGK LQDVFNLLPN LG TPDDDEI DVENHDRINI SNNLQKALTV KTNDELMVIY ISNLVRSIIA FDDLIENKIQ NKKIQEQ

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Macromolecule #27: 26S proteasome regulatory subunit RPN9

MacromoleculeName: 26S proteasome regulatory subunit RPN9 / type: protein_or_peptide / ID: 27 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 45.194625 KDa
SequenceString: EIDTILSTLR MEADPSLHPL FEQFEKFYEE KLWFQLSESL TKFFDDAKST PLRLRLYDNF VSKFYDKINQ LSVVKYLLAS LKDSKDFDE SLKYLDDLKA QFQELDSKKQ RNNGSKDHGD GILLIDSEIA RTYLLKNDLV KARDLLDDLE KTLDKKDSIP L RITNSFYS ...String:
EIDTILSTLR MEADPSLHPL FEQFEKFYEE KLWFQLSESL TKFFDDAKST PLRLRLYDNF VSKFYDKINQ LSVVKYLLAS LKDSKDFDE SLKYLDDLKA QFQELDSKKQ RNNGSKDHGD GILLIDSEIA RTYLLKNDLV KARDLLDDLE KTLDKKDSIP L RITNSFYS TNSQYFKFKN DFNSFYYTSL LYLSTLEPST SITLAERQQL AYDLSISALL GDKIYNFGEL LHHPIMETIV ND SNYDWLF QLLNALTVGD FDKFDSLIKV QISKIPILAQ HESFLRQKIC LMTLIETVFV KNIRMLSFED ISKATHLPKD NVE HLVMRA ISLGLLKGSI DQVNELVTIS WVQPRIISGD QITKMKDRLV EWNDQVEKLG KKMEARGQSI WV

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Macromolecule #28: 26S proteasome regulatory subunit 7 homolog

MacromoleculeName: 26S proteasome regulatory subunit 7 homolog / type: protein_or_peptide / ID: 28 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 47.318613 KDa
SequenceString: AAPYAAKLKQ TENDLKDIEA RIKEKAGVKE SDTGLAPSHL WDIMGDRQRL GEEHPLQVAR CTKIIKGNGE SDETTTDNNN SGNSNSNSN QQSTDADEDD EDAKYVINLK QIAKFVVGLG ERVSPTDIEE GMRVGVDRSK YNIELPLPPR IDPSVTMMTV E EKPDVTYS ...String:
AAPYAAKLKQ TENDLKDIEA RIKEKAGVKE SDTGLAPSHL WDIMGDRQRL GEEHPLQVAR CTKIIKGNGE SDETTTDNNN SGNSNSNSN QQSTDADEDD EDAKYVINLK QIAKFVVGLG ERVSPTDIEE GMRVGVDRSK YNIELPLPPR IDPSVTMMTV E EKPDVTYS DVGGCKDQIE KLREVVELPL LSPERFATLG IDPPKGILLY GPPGTGKTLC ARAVANRTDA TFIRVIGSEL VQ KYVGEGA RMVRELFEMA RTKKACIIFF DEIDAVGGAR FDDGAGGDNE VQRTMLELIT QLDGFDPRGN IKVMFATNRP NTL DPALLR PGRIDRKVEF SLPDLEGRAN IFRIHSKSMS VERGIRWELI SRLCPNSTGA ELRSVCTEAG MFAIRARRKV ATEK DFLKA VDKVISGYKK FSSTSRYMQY N

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Macromolecule #29: 26S proteasome regulatory subunit 4 homolog

MacromoleculeName: 26S proteasome regulatory subunit 4 homolog / type: protein_or_peptide / ID: 29 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 43.229602 KDa
SequenceString: TRCKLKLLRM ERIKDHLLLE EEFVSNSEIL KPFEKKQEEE KKQLEEIRGN PLSIGTLEEI IDDDHAIVTS PTMPDYYVSI LSFVDKELL EPGCSVLLHH KTMSIVGVLQ DDADPMVSVM KMDKSPTESY SDIGGLESQI QEIKESVELP LTHPELYEEM G IKPPKGVI ...String:
TRCKLKLLRM ERIKDHLLLE EEFVSNSEIL KPFEKKQEEE KKQLEEIRGN PLSIGTLEEI IDDDHAIVTS PTMPDYYVSI LSFVDKELL EPGCSVLLHH KTMSIVGVLQ DDADPMVSVM KMDKSPTESY SDIGGLESQI QEIKESVELP LTHPELYEEM G IKPPKGVI LYGAPGTGKT LLAKAVANQT SATFLRIVGS ELIQKYLGDG PRLCRQIFKV AGENAPSIVF IDEIDAIGTK RY DSNSGGE REIQRTMLEL LNQLDGFDDR GDVKVIMATN KIETLDPALI RPGRIDRKIL FENPDLSTKK KILGIHTSKM NLS EDVNLE TLVTTKDDLS GADIQAMCTE AGLLALRERR MQVTAEDFKQ AKERVMKNKV EENLEGLYL

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Macromolecule #30: 26S proteasome regulatory subunit 6B homolog

MacromoleculeName: 26S proteasome regulatory subunit 6B homolog / type: protein_or_peptide / ID: 30 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 43.325488 KDa
SequenceString: SDIYFKLKKL EKEYELLTLQ EDYIKDEQRH LKRELKRAQE EVKRIQSVPL VIGQFLEPID QNTGIVSSTT GMSYVVRILS TLDRELLKP SMSVALHRHS NALVDILPPD SDSSISVMGE NEKPDVTYAD VGGLDMQKQE IREAVELPLV QADLYEQIGI D PPRGVLLY ...String:
SDIYFKLKKL EKEYELLTLQ EDYIKDEQRH LKRELKRAQE EVKRIQSVPL VIGQFLEPID QNTGIVSSTT GMSYVVRILS TLDRELLKP SMSVALHRHS NALVDILPPD SDSSISVMGE NEKPDVTYAD VGGLDMQKQE IREAVELPLV QADLYEQIGI D PPRGVLLY GPPGTGKTML VKAVANSTKA AFIRVNGSEF VHKYLGEGPR MVRDVFRLAR ENAPSIIFID EVDSIATKRF DA QTGSDRE VQRILIELLT QMDGFDQSTN VKVIMATNRA DTLDPALLRP GRLDRKIEFP SLRDRRERRL IFGTIASKMS LAP EADLDS LIIRNDSLSG AVIAAIMQEA GLRAVRKNRY VILQSDLEEA YATQVKTDNT VDKFDFYK

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Macromolecule #31: 26S proteasome subunit RPT4

MacromoleculeName: 26S proteasome subunit RPT4 / type: protein_or_peptide / ID: 31 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 43.931473 KDa
SequenceString: EQEAHNKALN QFKRKLLEHR RYDDQLKQRR QNIRDLEKLY DKTENDIKAL QSIGQLIGEV MKELSEEKYI VKASSGPRYI VGVRNSVDR SKLKKGVRVT LDITTLTIMR ILPRETDPLV YNMTSFEQGE ITFDGIGGLT EQIRELREVI ELPLKNPEIF Q RVGIKPPK ...String:
EQEAHNKALN QFKRKLLEHR RYDDQLKQRR QNIRDLEKLY DKTENDIKAL QSIGQLIGEV MKELSEEKYI VKASSGPRYI VGVRNSVDR SKLKKGVRVT LDITTLTIMR ILPRETDPLV YNMTSFEQGE ITFDGIGGLT EQIRELREVI ELPLKNPEIF Q RVGIKPPK GVLLYGPPGT GKTLLAKAVA ATIGANFIFS PASGIVDKYI GESARIIREM FAYAKEHEPC IIFMDEVDAI GG RRFSEGT SADREIQRTL MELLTQMDGF DNLGQTKIIM ATNRPDTLDP ALLRPGRLDR KVEIPLPNEA GRLEIFKIHT AKV KKTGEF DFEAAVKMSD GFNGADIRNC ATEAGFFAIR DDRDHINPDD LMKAVRKVAE VKKLEGTIEY QK

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Macromolecule #32: 26S proteasome regulatory subunit 6A

MacromoleculeName: 26S proteasome regulatory subunit 6A / type: protein_or_peptide / ID: 32 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 46.902141 KDa
SequenceString: GDDELDQEIL NLSTQELQTR AKLLDNEIRI FRSELQRLSH ENNVMLEKIK DNKEKIKNNR QLPYLVANVV EVMDMNEIED KENSESTTQ GGNVNLDNTA VGKAAVVKTS SRQTVFLPMV GLVDPDKLKP NDLVGVNKDS YLILDTLPSE FDSRVKAMEV D EKPTETYS ...String:
GDDELDQEIL NLSTQELQTR AKLLDNEIRI FRSELQRLSH ENNVMLEKIK DNKEKIKNNR QLPYLVANVV EVMDMNEIED KENSESTTQ GGNVNLDNTA VGKAAVVKTS SRQTVFLPMV GLVDPDKLKP NDLVGVNKDS YLILDTLPSE FDSRVKAMEV D EKPTETYS DVGGLDKQIE ELVEAIVLPM KRADKFKDMG IRAPKGALMY GPPGTGKTLL ARACAAQTNA TFLKLAAPQL VQ MYIGEGA KLVRDAFALA KEKAPTIIFI DELDAIGTKR FDSEKSGDRE VQRTMLELLN QLDGFSSDDR VKVLAATNRV DVL DPALLR SGRLDRKIEF PLPSEDSRAQ ILQIHSRKMT TDDDINWQEL ARSTDEFNGA QLKAVTVEAG MIALRNGQSS VKHE DFVEG ISEVQARKSK SVSFYA

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Macromolecule #33: 26S proteasome regulatory subunit 8 homolog

MacromoleculeName: 26S proteasome regulatory subunit 8 homolog / type: protein_or_peptide / ID: 33 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Baker's yeast (brewer's yeast) / Strain: ATCC 204508 / S288c
Molecular weightTheoretical: 45.110445 KDa
SequenceString: AAVTSSNIVL ETHESGIKPY FEQKIQETEL KIRSKTENVR RLEAQRNALN DKVRFIKDEL RLLQEPGSYV GEVIKIVSDK KVLVKVQPE GKYIVDVAKD INVKDLKASQ RVCLRSDSYM LHKVLENKAD PLVSLMMVEK VPDSTYDMVG GLTKQIKEIK E VIELPVKH ...String:
AAVTSSNIVL ETHESGIKPY FEQKIQETEL KIRSKTENVR RLEAQRNALN DKVRFIKDEL RLLQEPGSYV GEVIKIVSDK KVLVKVQPE GKYIVDVAKD INVKDLKASQ RVCLRSDSYM LHKVLENKAD PLVSLMMVEK VPDSTYDMVG GLTKQIKEIK E VIELPVKH PELFESLGIA QPKGVILYGP PGTGKTLLAR AVAHHTDCKF IRVSGAELVQ KYIGEGSRMV RELFVMAREH AP SIIFMDE IDSIGSTRVE GSGGGDSEVQ RTMLELLNQL DGFETSKNIK IIMATNRLDI LDPALLRPGR IDRKIEFPPP SVA ARAEIL RIHSRKMNLT RGINLRKVAE KMNGCSGADV KGVCTEAGMY ALRERRIHVT QEDFELAVGK VMNKNQETAI SVAK LFK

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Macromolecule #34: ADENOSINE-5'-TRIPHOSPHATE

MacromoleculeName: ADENOSINE-5'-TRIPHOSPHATE / type: ligand / ID: 34 / Number of copies: 4 / Formula: ATP
Molecular weightTheoretical: 507.181 Da
Chemical component information

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM / Adenosine triphosphate

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Macromolecule #35: MAGNESIUM ION

MacromoleculeName: MAGNESIUM ION / type: ligand / ID: 35 / Number of copies: 6 / Formula: MG
Molecular weightTheoretical: 24.305 Da

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Macromolecule #36: ADENOSINE-5'-DIPHOSPHATE

MacromoleculeName: ADENOSINE-5'-DIPHOSPHATE / type: ligand / ID: 36 / Number of copies: 2 / Formula: ADP
Molecular weightTheoretical: 427.201 Da
Chemical component information

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM / Adenosine diphosphate

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Macromolecule #37: water

MacromoleculeName: water / type: ligand / ID: 37 / Number of copies: 20 / Formula: HOH
Molecular weightTheoretical: 18.015 Da
Chemical component information

ChemComp-HOH:
WATER / Water

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Experimental details

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Structure determination

Methodcryo EM
Processingsingle particle reconstruction
Aggregation stateparticle

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Sample preparation

BufferpH: 7.4
VitrificationCryogen name: ETHANE-PROPANE

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Electron microscopy

MicroscopeFEI TITAN KRIOS
Electron beamAcceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN
Electron opticsIllumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELDBright-field microscopy
Image recordingFilm or detector model: GATAN K2 SUMMIT (4k x 4k) / Average electron dose: 35.0 e/Å2
Experimental equipment
Model: Titan Krios / Image courtesy: FEI Company

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Image processing

Startup modelType of model: PDB ENTRY
PDB model - PDB ID:
Initial angle assignmentType: PROJECTION MATCHING
Final angle assignmentType: PROJECTION MATCHING
Final reconstructionResolution.type: BY AUTHOR / Resolution: 4.5 Å / Resolution method: FSC 0.143 CUT-OFF / Number images used: 351984

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