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- EMDB-4321: 26S proteasome, s3 state -

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Basic information

Entry
Database: EMDB / ID: EMD-4321
Title26S proteasome, s3 state
Map data26S proteasome state s3
Sample
  • Complex: 26S proteasome
    • Protein or peptide: x 33 types
  • Ligand: x 3 types
Keywords26S proteasome / AAA+ ATPase / hydrolase
Function / homology
Function and homology information


SAGA complex localization to transcription regulatory region / Metalloprotease DUBs / proteasome regulatory particle assembly / proteasome storage granule assembly / transcription export complex 2 / protein deneddylation / peroxisome fission / maintenance of DNA trinucleotide repeats / filamentous growth / COP9 signalosome ...SAGA complex localization to transcription regulatory region / Metalloprotease DUBs / proteasome regulatory particle assembly / proteasome storage granule assembly / transcription export complex 2 / protein deneddylation / peroxisome fission / maintenance of DNA trinucleotide repeats / filamentous growth / COP9 signalosome / protein-containing complex localization / proteasome regulatory particle / proteasome-activating activity / mitochondrial fission / proteasome regulatory particle, lid subcomplex / proteasome regulatory particle, base subcomplex / metal-dependent deubiquitinase activity / K48-linked polyubiquitin modification-dependent protein binding / proteasome core complex assembly / nuclear outer membrane-endoplasmic reticulum membrane network / Proteasome assembly / Cross-presentation of soluble exogenous antigens (endosomes) / TNFR2 non-canonical NF-kB pathway / proteasomal ubiquitin-independent protein catabolic process / Ubiquitin Mediated Degradation of Phosphorylated Cdc25A / Regulation of PTEN stability and activity / nonfunctional rRNA decay / CDK-mediated phosphorylation and removal of Cdc6 / FBXL7 down-regulates AURKA during mitotic entry and in early mitosis / peptide catabolic process / KEAP1-NFE2L2 pathway / Neddylation / proteasome binding / Orc1 removal from chromatin / MAPK6/MAPK4 signaling / regulation of protein catabolic process / proteasome storage granule / Antigen processing: Ubiquitination & Proteasome degradation / polyubiquitin modification-dependent protein binding / positive regulation of RNA polymerase II transcription preinitiation complex assembly / protein deubiquitination / endopeptidase activator activity / Ub-specific processing proteases / proteasome endopeptidase complex / proteasome core complex, beta-subunit complex / proteasome assembly / threonine-type endopeptidase activity / proteasome core complex, alpha-subunit complex / mRNA export from nucleus / enzyme regulator activity / ERAD pathway / Neutrophil degranulation / protein folding chaperone / proteasome complex / ubiquitin binding / nucleotide-excision repair / positive regulation of transcription elongation by RNA polymerase II / double-strand break repair via homologous recombination / positive regulation of protein catabolic process / metallopeptidase activity / peroxisome / ubiquitin-dependent protein catabolic process / protein-macromolecule adaptor activity / endopeptidase activity / molecular adaptor activity / proteasome-mediated ubiquitin-dependent protein catabolic process / ubiquitinyl hydrolase 1 / cysteine-type deubiquitinase activity / regulation of cell cycle / chromatin remodeling / protein domain specific binding / mRNA binding / ubiquitin protein ligase binding / endoplasmic reticulum membrane / structural molecule activity / endoplasmic reticulum / positive regulation of transcription by RNA polymerase II / ATP hydrolysis activity / mitochondrion / ATP binding / metal ion binding / identical protein binding / nucleus / cytosol / cytoplasm
Similarity search - Function
Rpn9, C-terminal helix / Rpn9 C-terminal helix / Proteasomal ubiquitin receptor Rpn13/ADRM1 / Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily / Rpn13/ADRM1, Pru domain / Proteasome complex subunit Rpn13, Pru domain / Pru (pleckstrin-like receptor for ubiquitin) domain profile. / : / 26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix / 26S proteasome non-ATPase regulatory subunit Rpn12 ...Rpn9, C-terminal helix / Rpn9 C-terminal helix / Proteasomal ubiquitin receptor Rpn13/ADRM1 / Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily / Rpn13/ADRM1, Pru domain / Proteasome complex subunit Rpn13, Pru domain / Pru (pleckstrin-like receptor for ubiquitin) domain profile. / : / 26S proteasome regulatory subunit RPN7/PSMD6 C-terminal helix / 26S proteasome non-ATPase regulatory subunit Rpn12 / 26S proteasome regulatory subunit, C-terminal / Proteasome regulatory subunit C-terminal / 26S proteasome regulatory subunit RPN5, C-terminal domain / : / 26S proteasome regulatory subunit RPN5 C-terminal domain / PSD13 N-terminal repeats / 26S proteasome regulatory subunit Rpn6, N-terminal / 6S proteasome subunit Rpn6, C-terminal helix domain / 26S proteasome regulatory subunit RPN6 N-terminal domain / 26S proteasome subunit RPN6 C-terminal helix domain / 26S Proteasome non-ATPase regulatory subunit 13 / : / 26S proteasome subunit RPN2, N-terminal domain / 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit / 26S proteasome regulatory subunit RPN2, C-terminal / 26S proteasome regulatory subunit RPN2 C-terminal domain / : / 26S proteasome regulatory subunit RPN11 C-terminal domain / DSS1/SEM1 / Proteasome subunit Rpn10 / 26S Proteasome non-ATPase regulatory subunit 7/8 / DSS1/SEM1 family / DSS1_SEM1 / 26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit / RPN1, N-terminal / 26S proteasome non-ATPase regulatory subunit RPN1, C-terminal / RPN1 N-terminal domain / 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal / : / 26S proteasome regulatory subunit 7, OB domain / : / : / : / PSMD12/CSN4, N-terminal / 26S proteasome regulatory subunit Rpn7/COP9 signalosome complex subunit 1 / 26S proteasome regulatory subunit Rpn7, N-terminal / 26S proteasome subunit RPN7 / 26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4 / Proteasome/cyclosome repeat / Proteasome/cyclosome repeat / PCI/PINT associated module / : / von Willebrand factor type A domain / Proteasomal ATPase OB C-terminal domain / Proteasomal ATPase OB C-terminal domain / CSN8/PSMD8/EIF3K / CSN8/PSMD8/EIF3K family / Rpn11/EIF3F, C-terminal / Maintenance of mitochondrial structure and function / HEAT repeats / : / motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 / PCI domain / Proteasome component (PCI) domain / PCI domain profile. / Ubiquitin interacting motif / Ubiquitin-interacting motif (UIM) domain profile. / JAB1/Mov34/MPN/PAD-1 ubiquitin protease / Proteasome beta subunit, C-terminal / Proteasome beta subunits C terminal / Proteasome subunit beta 4 / Proteasome subunit beta 2 / Proteasome beta 3 subunit / Proteasome subunit alpha6 / Proteasome subunit alpha5 / Proteasome beta-type subunits signature. / Peptidase T1A, proteasome beta-subunit / Proteasome beta-type subunit, conserved site / Proteasome subunit A N-terminal signature / Proteasome alpha-type subunits signature. / Proteasome alpha-subunit, N-terminal domain / Proteasome subunit A N-terminal signature Add an annotation / VWFA domain profile. / Proteasome B-type subunit / Proteasome beta-type subunit profile. / : / Proteasome alpha-type subunit / Proteasome alpha-type subunit profile. / Proteasome subunit / Proteasome, subunit alpha/beta / von Willebrand factor, type A / AAA ATPase, AAA+ lid domain / AAA+ lid domain / TPR repeat region circular profile. / JAB/MPN domain / JAB1/MPN/MOV34 metalloenzyme domain / ATPase, AAA-type, conserved site / AAA-protein family signature. / TPR repeat profile. / MPN domain
Similarity search - Domain/homology
26S proteasome regulatory subunit RPN13 / 26S proteasome complex subunit SEM1 / Probable proteasome subunit alpha type-7 / Proteasome subunit alpha type-1 / Proteasome subunit beta type-4 / Proteasome subunit alpha type-3 / Proteasome subunit alpha type-2 / Proteasome subunit beta type-6 / Proteasome subunit beta type-2 / Proteasome subunit beta type-3 ...26S proteasome regulatory subunit RPN13 / 26S proteasome complex subunit SEM1 / Probable proteasome subunit alpha type-7 / Proteasome subunit alpha type-1 / Proteasome subunit beta type-4 / Proteasome subunit alpha type-3 / Proteasome subunit alpha type-2 / Proteasome subunit beta type-6 / Proteasome subunit beta type-2 / Proteasome subunit beta type-3 / Proteasome subunit beta type-5 / Proteasome subunit beta type-7 / Proteasome subunit alpha type-5 / 26S proteasome regulatory subunit RPN12 / 26S proteasome regulatory subunit RPN2 / 26S proteasome regulatory subunit 6A / 26S proteasome regulatory subunit 6B homolog / 26S proteasome regulatory subunit 7 homolog / Proteasome subunit beta type-1 / 26S proteasome regulatory subunit RPN1 / 26S proteasome regulatory subunit RPN10 / 26S proteasome regulatory subunit RPN3 / Proteasome subunit alpha type-6 / Proteasome subunit alpha type-4 / 26S proteasome regulatory subunit 4 homolog / Ubiquitin carboxyl-terminal hydrolase RPN11 / 26S proteasome subunit RPT4 / 26S proteasome regulatory subunit 8 homolog / 26S proteasome regulatory subunit RPN9 / 26S proteasome regulatory subunit RPN7 / 26S proteasome regulatory subunit RPN8 / 26S proteasome regulatory subunit RPN5 / 26S proteasome regulatory subunit RPN6
Similarity search - Component
Biological speciesSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Methodsingle particle reconstruction / cryo EM / Resolution: 5.4 Å
AuthorsEisele MR / Reed RG
CitationJournal: Cell Rep / Year: 2018
Title: Expanded Coverage of the 26S Proteasome Conformational Landscape Reveals Mechanisms of Peptidase Gating.
Authors: Markus R Eisele / Randi G Reed / Till Rudack / Andreas Schweitzer / Florian Beck / Istvan Nagy / Günter Pfeifer / Jürgen M Plitzko / Wolfgang Baumeister / Robert J Tomko / Eri Sakata /
Abstract: The proteasome is the central protease for intracellular protein breakdown. Coordinated binding and hydrolysis of ATP by the six proteasomal ATPase subunits induces conformational changes that drive ...The proteasome is the central protease for intracellular protein breakdown. Coordinated binding and hydrolysis of ATP by the six proteasomal ATPase subunits induces conformational changes that drive the unfolding and translocation of substrates into the proteolytic 20S core particle for degradation. Here, we combine genetic and biochemical approaches with cryo-electron microscopy and integrative modeling to dissect the relationship between individual nucleotide binding events and proteasome conformational dynamics. We demonstrate unique impacts of ATP binding by individual ATPases on the proteasome conformational distribution and report two conformational states of the proteasome suggestive of a rotary ATP hydrolysis mechanism. These structures, coupled with functional analyses, reveal key roles for the ATPases Rpt1 and Rpt6 in gating substrate entry into the core particle. This deepened knowledge of proteasome conformational dynamics reveals key elements of intersubunit communication within the proteasome and clarifies the regulation of substrate entry into the proteolytic chamber.
History
DepositionMar 5, 2018-
Header (metadata) releaseMay 30, 2018-
Map releaseAug 22, 2018-
UpdateMay 15, 2024-
Current statusMay 15, 2024Processing site: PDBe / Status: Released

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Structure visualization

Movie
  • Surface view with section colored by density value
  • Surface level: 0.01
  • Imaged by UCSF Chimera
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  • Surface view colored by radius
  • Surface level: 0.01
  • Imaged by UCSF Chimera
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  • Surface view with fitted model
  • Atomic models: PDB-6fvv
  • Surface level: 0.01
  • Imaged by UCSF Chimera
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Movie viewer
Structure viewerEM map:
SurfViewMolmilJmol/JSmol
Supplemental images

emd_4321.png

Downloads & links

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Map

FileDownload / File: emd_4321.map.gz / Format: CCP4 / Size: 216 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
Annotation26S proteasome state s3
Projections & slices

Image control

Size
Brightness
Contrast
Others
AxesZ (Sec.)Y (Row.)X (Col.)
1.38 Å/pix.
x 384 pix.
= 529.92 Å		1.38 Å/pix.
x 384 pix.
= 529.92 Å		1.38 Å/pix.
x 384 pix.
= 529.92 Å

Surface

Projections

Slices (1/3)

Slices (1/2)

Slices (2/3)

Images are generated by Spider.

Voxel sizeX=Y=Z: 1.38 Å
Density

Histogram

Histogram (log scale)
Contour LevelBy AUTHOR: 0.01 / Movie #1: 0.01
Minimum - Maximum-0.04806745 - 0.08588476
Average (Standard dev.)0.0000084623425 (±0.0026427729)
SymmetrySpace group: 1
Details

EMDB XML:

Map geometry
Axis orderXYZ
Origin000
Dimensions384384384
Spacing384384384
CellA=B=C: 529.92 Å
α=β=γ: 90.0 °

CCP4 map header:

modeImage stored as Reals
Å/pix. X/Y/Z1.381.381.38
M x/y/z384384384
origin x/y/z0.0000.0000.000
length x/y/z529.920529.920529.920
α/β/γ90.00090.00090.000
MAP C/R/S123
start NC/NR/NS000
NC/NR/NS384384384
D min/max/mean-0.0480.0860.000

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Supplemental data

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Sample components

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Entire : 26S proteasome

EntireName: 26S proteasome
Components
  • Complex: 26S proteasome
    • Protein or peptide: Proteasome subunit alpha type-1
    • Protein or peptide: Proteasome subunit alpha type-2
    • Protein or peptide: Proteasome subunit alpha type-3
    • Protein or peptide: Proteasome subunit alpha type-4
    • Protein or peptide: Proteasome subunit alpha type-5
    • Protein or peptide: Proteasome subunit alpha type-6
    • Protein or peptide: Probable proteasome subunit alpha type-7
    • Protein or peptide: Proteasome subunit beta type-1
    • Protein or peptide: Proteasome subunit beta type-2
    • Protein or peptide: Proteasome subunit beta type-3
    • Protein or peptide: Proteasome subunit beta type-4
    • Protein or peptide: Proteasome subunit beta type-5
    • Protein or peptide: Proteasome subunit beta type-6
    • Protein or peptide: Proteasome subunit beta type-7
    • Protein or peptide: 26S proteasome regulatory subunit RPN10
    • Protein or peptide: Ubiquitin carboxyl-terminal hydrolase RPN11
    • Protein or peptide: 26S proteasome regulatory subunit RPN12
    • Protein or peptide: 26S proteasome regulatory subunit RPN13
    • Protein or peptide: 26S proteasome complex subunit SEM1
    • Protein or peptide: 26S proteasome regulatory subunit RPN1
    • Protein or peptide: 26S proteasome regulatory subunit RPN2
    • Protein or peptide: 26S proteasome regulatory subunit RPN3
    • Protein or peptide: 26S proteasome regulatory subunit RPN5
    • Protein or peptide: 26S proteasome regulatory subunit RPN6
    • Protein or peptide: 26S proteasome regulatory subunit RPN7
    • Protein or peptide: 26S proteasome regulatory subunit RPN8
    • Protein or peptide: 26S proteasome regulatory subunit RPN9
    • Protein or peptide: 26S proteasome regulatory subunit 7 homolog
    • Protein or peptide: 26S proteasome regulatory subunit 4 homolog
    • Protein or peptide: 26S proteasome regulatory subunit 6B homolog
    • Protein or peptide: 26S proteasome subunit RPT4
    • Protein or peptide: 26S proteasome regulatory subunit 6A
    • Protein or peptide: 26S proteasome regulatory subunit 8 homolog
  • Ligand: ADENOSINE-5'-DIPHOSPHATE
  • Ligand: MAGNESIUM ION
  • Ligand: ADENOSINE-5'-TRIPHOSPHATE

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Supramolecule #1: 26S proteasome

SupramoleculeName: 26S proteasome / type: complex / ID: 1 / Parent: 0 / Macromolecule list: #1-#33
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)

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Macromolecule #1: Proteasome subunit alpha type-1

MacromoleculeName: Proteasome subunit alpha type-1 / type: protein_or_peptide / ID: 1 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 27.129869 KDa
SequenceString: GYDRHITIFS PEGRLYQVEY AFKATNQTNI NSLAVRGKDC TVVISQKKVP DKLLDPTTVS YIFCISRTIG MVVNGPIPDA RNAALRAKA EAAEFRYKYG YDMPCDVLAK RMANLSQIYT QRAYMRPLGV ILTFVSVDEE LGPSIYKTDP AGYYVGYKAT A TGPKQQEI ...String:
GYDRHITIFS PEGRLYQVEY AFKATNQTNI NSLAVRGKDC TVVISQKKVP DKLLDPTTVS YIFCISRTIG MVVNGPIPDA RNAALRAKA EAAEFRYKYG YDMPCDVLAK RMANLSQIYT QRAYMRPLGV ILTFVSVDEE LGPSIYKTDP AGYYVGYKAT A TGPKQQEI TTNLENHFKK SKIDHINEES WEKVVEFAIT HMIDALGTEF SKNDLEVGVA TKDKFFTLSA ENIEERLVAI AE Q

UniProtKB: Proteasome subunit alpha type-1

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Macromolecule #2: Proteasome subunit alpha type-2

MacromoleculeName: Proteasome subunit alpha type-2 / type: protein_or_peptide / ID: 2 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 27.060631 KDa
SequenceString: TDRYSFSLTT FSPSGKLGQI DYALTAVKQG VTSLGIKATN GVVIATEKKS SSPLAMSETL SKVSLLTPDI GAVYSGMGPD YRVLVDKSR KVAHTSYKRI YGEYPPTKLL VSEVAKIMQE ATQSGGVRPF GVSLLIAGHD EFNGFSLYQV DPSGSYFPWK A TAIGKGSV ...String:
TDRYSFSLTT FSPSGKLGQI DYALTAVKQG VTSLGIKATN GVVIATEKKS SSPLAMSETL SKVSLLTPDI GAVYSGMGPD YRVLVDKSR KVAHTSYKRI YGEYPPTKLL VSEVAKIMQE ATQSGGVRPF GVSLLIAGHD EFNGFSLYQV DPSGSYFPWK A TAIGKGSV AAKTFLEKRW NDELELEDAI HIALLTLKES VEGEFNGDTI ELAIIGDENP DLLGYTGIPT DKGPRFRKLT SQ EINDRLE AL

UniProtKB: Proteasome subunit alpha type-2

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Macromolecule #3: Proteasome subunit alpha type-3

MacromoleculeName: Proteasome subunit alpha type-3 / type: protein_or_peptide / ID: 3 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 27.050416 KDa
SequenceString: GSRRYDSRTT IFSPEGRLYQ VEYALESISH AGTAIGIMAS DGIVLAAERK VTSTLLEQDT STEKLYKLND KIAVAVAGLT ADAEILINT ARIHAQNYLK TYNEDIPVEI LVRRLSDIKQ GYTQHGGLRP FGVSFIYAGY DDRYGYQLYT SNPSGNYTGW K AISVGANT ...String:
GSRRYDSRTT IFSPEGRLYQ VEYALESISH AGTAIGIMAS DGIVLAAERK VTSTLLEQDT STEKLYKLND KIAVAVAGLT ADAEILINT ARIHAQNYLK TYNEDIPVEI LVRRLSDIKQ GYTQHGGLRP FGVSFIYAGY DDRYGYQLYT SNPSGNYTGW K AISVGANT SAAQTLLQMD YKDDMKVDDA IELALKTLSK TTDSSALTYD RLEFATIRKG ANDGEVYQKI FKPQEIKDIL VK TGIT

UniProtKB: Proteasome subunit alpha type-3

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Macromolecule #4: Proteasome subunit alpha type-4

MacromoleculeName: Proteasome subunit alpha type-4 / type: protein_or_peptide / ID: 4 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 28.202787 KDa
SequenceString: YDRALSIFSP DGHIFQVEYA LEAVKRGTCA VGVKGKNCVV LGCERRSTLK LQDTRITPSK VSKIDSHVVL SFSGLNADSR ILIEKARVE AQSHRLTLED PVTVEYLTRY VAGVQQRYTQ SGGVRPFGVS TLIAGFDPRD DEPKLYQTEP SGIYSSWSAQ T IGRNSKTV ...String:
YDRALSIFSP DGHIFQVEYA LEAVKRGTCA VGVKGKNCVV LGCERRSTLK LQDTRITPSK VSKIDSHVVL SFSGLNADSR ILIEKARVE AQSHRLTLED PVTVEYLTRY VAGVQQRYTQ SGGVRPFGVS TLIAGFDPRD DEPKLYQTEP SGIYSSWSAQ T IGRNSKTV REFLEKNYDR KEPPATVEEC VKLTVRSLLE VVQTGAKNIE ITVVKPDSDI VALSSEEINQ YVTQIEQEKQ EQ QEQDKKK KSNH

UniProtKB: Proteasome subunit alpha type-4

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Macromolecule #5: Proteasome subunit alpha type-5

MacromoleculeName: Proteasome subunit alpha type-5 / type: protein_or_peptide / ID: 5 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 26.83708 KDa
SequenceString: EYDRGVSTFS PEGRLFQVEY SLEAIKLGST AIGIATKEGV VLGVEKRATS PLLESDSIEK IVEIDRHIGC AMSGLTADAR SMIEHARTA AVTHNLYYDE DINVESLTQS VCDLALRFGE GASGEERLMS RPFGVALLIA GHDADDGYQL FHAEPSGTFY R YNAKAIGS ...String:
EYDRGVSTFS PEGRLFQVEY SLEAIKLGST AIGIATKEGV VLGVEKRATS PLLESDSIEK IVEIDRHIGC AMSGLTADAR SMIEHARTA AVTHNLYYDE DINVESLTQS VCDLALRFGE GASGEERLMS RPFGVALLIA GHDADDGYQL FHAEPSGTFY R YNAKAIGS GSEGAQAELL NEWHSSLTLK EAELLVLKIL KQVMEEKLDE NNAQLSCITK QDGFKIYDNE KTAELIKELK EK EAAE

UniProtKB: Proteasome subunit alpha type-5

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Macromolecule #6: Proteasome subunit alpha type-6

MacromoleculeName: Proteasome subunit alpha type-6 / type: protein_or_peptide / ID: 6 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 25.198438 KDa
SequenceString: NNYDGDTVTF SPTGRLFQVE YALEAIKQGS VTVGLRSNTH AVLVALKRNA DELSSYQKKI IKCDEHMGLS LAGLAPDARV LSNYLRQQC NYSSLVFNRK LAVERAGHLL CDKAQKNTQS YGGRPYGVGL LIIGYDKSGA HLLEFQPSGN VTELYGTAIG A RSQGAKTY ...String:
NNYDGDTVTF SPTGRLFQVE YALEAIKQGS VTVGLRSNTH AVLVALKRNA DELSSYQKKI IKCDEHMGLS LAGLAPDARV LSNYLRQQC NYSSLVFNRK LAVERAGHLL CDKAQKNTQS YGGRPYGVGL LIIGYDKSGA HLLEFQPSGN VTELYGTAIG A RSQGAKTY LERTLDTFIK IDGNPDELIK AGVEAISQSL RDESLTVDNL SIAIVGKDTP FTIYDGEAVA KYI

UniProtKB: Proteasome subunit alpha type-6

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Macromolecule #7: Probable proteasome subunit alpha type-7

MacromoleculeName: Probable proteasome subunit alpha type-7 / type: protein_or_peptide / ID: 7 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 26.734328 KDa
SequenceString: GYDLSNSVFS PDGRNFQVEY AVKAVENGTT SIGIKCNDGV VFAVEKLITS KLLVPQKNVK IQVVDRHIGC VYSGLIPDGR HLVNRGREE AASFKKLYKT PIPIPAFADR LGQYVQAHTL YNSVRPFGVS TIFGGVDKNG AHLYMLEPSG SYWGYKGAAT G KGRQSAKA ...String:
GYDLSNSVFS PDGRNFQVEY AVKAVENGTT SIGIKCNDGV VFAVEKLITS KLLVPQKNVK IQVVDRHIGC VYSGLIPDGR HLVNRGREE AASFKKLYKT PIPIPAFADR LGQYVQAHTL YNSVRPFGVS TIFGGVDKNG AHLYMLEPSG SYWGYKGAAT G KGRQSAKA ELEKLVDHHP EGLSAREAVK QAAKIIYLAH EDNKEKDFEL EISWCSLSET NGLHKFVKGD LLQEAIDFAQ KE IN

UniProtKB: Probable proteasome subunit alpha type-7

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Macromolecule #8: Proteasome subunit beta type-1

MacromoleculeName: Proteasome subunit beta type-1 / type: protein_or_peptide / ID: 8 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 21.517186 KDa
SequenceString: TSIMAVTFKD GVILGADSRT TTGAYIANRV TDKLTRVHDK IWCCRSGSAA DTQAIADIVQ YHLELYTSQY GTPSTETAAS VFKELCYEN KDNLTAGIIV AGYDDKNKGE VYTIPLGGSV HKLPYAIAGS GSTFIYGYCD KNFRENMSKE ETVDFIKHSL S QAIKWDGS ...String:
TSIMAVTFKD GVILGADSRT TTGAYIANRV TDKLTRVHDK IWCCRSGSAA DTQAIADIVQ YHLELYTSQY GTPSTETAAS VFKELCYEN KDNLTAGIIV AGYDDKNKGE VYTIPLGGSV HKLPYAIAGS GSTFIYGYCD KNFRENMSKE ETVDFIKHSL S QAIKWDGS SGGVIRMVVL TAAGVERLIF YPDEYEQL

UniProtKB: Proteasome subunit beta type-1

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Macromolecule #9: Proteasome subunit beta type-2

MacromoleculeName: Proteasome subunit beta type-2 / type: protein_or_peptide / ID: 9 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 24.48677 KDa
SequenceString: TTIVGVKFNN GVVIAADTRS TQGPIVADKN CAKLHRISPK IWCAGAGTAA DTEAVTQLIG SNIELHSLYT SREPRVVSAL QMLKQHLFK YQGHIGAYLI VAGVDPTGSH LFSIHAHGST DVGYYLSLGS GSLAAMAVLE SHWKQDLTKE EAIKLASDAI Q AGIWNDLG ...String:
TTIVGVKFNN GVVIAADTRS TQGPIVADKN CAKLHRISPK IWCAGAGTAA DTEAVTQLIG SNIELHSLYT SREPRVVSAL QMLKQHLFK YQGHIGAYLI VAGVDPTGSH LFSIHAHGST DVGYYLSLGS GSLAAMAVLE SHWKQDLTKE EAIKLASDAI Q AGIWNDLG SGSNVDVCVM EIGKDAEYLR NYLTPNVREE KQKSYKFPRG TTAVLKESIV NICDIQEE

UniProtKB: Proteasome subunit beta type-2

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Macromolecule #10: Proteasome subunit beta type-3

MacromoleculeName: Proteasome subunit beta type-3 / type: protein_or_peptide / ID: 10 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 22.496645 KDa
SequenceString: SDPSSINGGI VVAMTGKDCV AIACDLRLGS QSLGVSNKFE KIFHYGHVFL GITGLATDVT TLNEMFRYKT NLYKLKEERA IEPETFTQL VSSSLYERRF GPYFVGPVVA GINSKSGKPF IAGFDLIGCI DEAKDFIVSG TASDQLFGMC ESLYEPNLEP E DLFETISQ ...String:
SDPSSINGGI VVAMTGKDCV AIACDLRLGS QSLGVSNKFE KIFHYGHVFL GITGLATDVT TLNEMFRYKT NLYKLKEERA IEPETFTQL VSSSLYERRF GPYFVGPVVA GINSKSGKPF IAGFDLIGCI DEAKDFIVSG TASDQLFGMC ESLYEPNLEP E DLFETISQ ALLNAADRDA LSGWGAVVYI IKKDEVVKRY LKMRQD

UniProtKB: Proteasome subunit beta type-3

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Macromolecule #11: Proteasome subunit beta type-4

MacromoleculeName: Proteasome subunit beta type-4 / type: protein_or_peptide / ID: 11 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 22.218338 KDa
SequenceString: MDIILGIRVQ DSVILASSKA VTRGISVLKD SDDKTRQLSP HTLMSFAGEA GDTVQFAEYI QANIQLYSIR EDYELSPQAV SSFVRQELA KSIRSRRPYQ VNVLIGGYDK KKNKPELYQI DYLGTKVELP YGAHGYSGFY TFSLLDHHYR PDMTTEEGLD L LKLCVQEL ...String:
MDIILGIRVQ DSVILASSKA VTRGISVLKD SDDKTRQLSP HTLMSFAGEA GDTVQFAEYI QANIQLYSIR EDYELSPQAV SSFVRQELA KSIRSRRPYQ VNVLIGGYDK KKNKPELYQI DYLGTKVELP YGAHGYSGFY TFSLLDHHYR PDMTTEEGLD L LKLCVQEL EKRMPMDFKG VIVKIVDKDG IRQVDDF

UniProtKB: Proteasome subunit beta type-4

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Macromolecule #12: Proteasome subunit beta type-5

MacromoleculeName: Proteasome subunit beta type-5 / type: protein_or_peptide / ID: 12 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 23.325248 KDa
SequenceString: TTTLAFRFQG GIIVAVDSRA TAGNWVASQT VKKVIEINPF LLGTMAGGAA DCQFWETWLG SQCRLHELRE KERISVAAAS KILSNLVYQ YKGAGLSMGT MICGYTRKEG PTIYYVDSDG TRLKGDIFCV GSGQTFAYGV LDSNYKWDLS VEDALYLGKR S ILAAAHRD ...String:
TTTLAFRFQG GIIVAVDSRA TAGNWVASQT VKKVIEINPF LLGTMAGGAA DCQFWETWLG SQCRLHELRE KERISVAAAS KILSNLVYQ YKGAGLSMGT MICGYTRKEG PTIYYVDSDG TRLKGDIFCV GSGQTFAYGV LDSNYKWDLS VEDALYLGKR S ILAAAHRD AYSGGSVNLY HVTEDGWIYH GNHDVGELFW KVKEEEGSFN NVIG

UniProtKB: Proteasome subunit beta type-5

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Macromolecule #13: Proteasome subunit beta type-6

MacromoleculeName: Proteasome subunit beta type-6 / type: protein_or_peptide / ID: 13 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 24.883928 KDa
SequenceString: QFNPYGDNGG TILGIAGEDF AVLAGDTRNI TDYSINSRYE PKVFDCGDNI VMSANGFAAD GDALVKRFKN SVKWYHFDHN DKKLSINSA ARNIQHLLYG KRFFPYYVHT IIAGLDEDGK GAVYSFDPVG SYEREQCRAG GAAASLIMPF LDNQVNFKNQ Y EPGTNGKV ...String:
QFNPYGDNGG TILGIAGEDF AVLAGDTRNI TDYSINSRYE PKVFDCGDNI VMSANGFAAD GDALVKRFKN SVKWYHFDHN DKKLSINSA ARNIQHLLYG KRFFPYYVHT IIAGLDEDGK GAVYSFDPVG SYEREQCRAG GAAASLIMPF LDNQVNFKNQ Y EPGTNGKV KKPLKYLSVE EVIKLVRDSF TSATERHIQV GDGLEILIVT KDGVRKEFYE LKRD

UniProtKB: Proteasome subunit beta type-6

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Macromolecule #14: Proteasome subunit beta type-7

MacromoleculeName: Proteasome subunit beta type-7 / type: protein_or_peptide / ID: 14 / Number of copies: 2 / Enantiomer: LEVO / EC number: proteasome endopeptidase complex
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 25.832336 KDa
SequenceString: TQQPIVTGTS VISMKYDNGV IIAADNLGSY GSLLRFNGVE RLIPVGDNTV VGISGDISDM QHIERLLKDL VTENAYDNPL ADAEEALEP SYIFEYLATV MYQRRSKMNP LWNAIIVAGV QSNGDQFLRY VNLLGVTYSS PTLATGFGAH MANPLLRKVV D RESDIPKT ...String:
TQQPIVTGTS VISMKYDNGV IIAADNLGSY GSLLRFNGVE RLIPVGDNTV VGISGDISDM QHIERLLKDL VTENAYDNPL ADAEEALEP SYIFEYLATV MYQRRSKMNP LWNAIIVAGV QSNGDQFLRY VNLLGVTYSS PTLATGFGAH MANPLLRKVV D RESDIPKT TVQVAEEAIV NAMRVLYYRD ARSSRNFSLA IIDKNTGLTF KKNLQVENMK WDFAKDIKGY GTQK

UniProtKB: Proteasome subunit beta type-7

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Macromolecule #15: 26S proteasome regulatory subunit RPN10

MacromoleculeName: 26S proteasome regulatory subunit RPN10 / type: protein_or_peptide / ID: 15 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 21.818613 KDa
SequenceString: MVLEATVLVI DNSEYSRNGD FPRTRFEAQI DSVEFIFQAK RNSNPENTVG LISGAGANPR VLSTFTAEFG KILAGLHDTQ IEGKLHMAT ALQIAQLTLK HRQNKVQHQR IVAFVCSPIS DSRDELIRLA KTLKKNNVAV DIINFGEIEQ NTELLDEFIA A VNNPQEET ...String:
MVLEATVLVI DNSEYSRNGD FPRTRFEAQI DSVEFIFQAK RNSNPENTVG LISGAGANPR VLSTFTAEFG KILAGLHDTQ IEGKLHMAT ALQIAQLTLK HRQNKVQHQR IVAFVCSPIS DSRDELIRLA KTLKKNNVAV DIINFGEIEQ NTELLDEFIA A VNNPQEET SHLLTVTPGP RLLYENIASS PIILEEGSS

UniProtKB: 26S proteasome regulatory subunit RPN10

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Macromolecule #16: Ubiquitin carboxyl-terminal hydrolase RPN11

MacromoleculeName: Ubiquitin carboxyl-terminal hydrolase RPN11 / type: protein_or_peptide / ID: 16 / Number of copies: 1 / Enantiomer: LEVO / EC number: ubiquitinyl hydrolase 1
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 32.490963 KDa
SequenceString: TGRDDTKETV YISSIALLKM LKHGRAGVPM EVMGLMLGEF VDDYTVNVVD VFAMPQSGTG VSVEAVDDVF QAKMMDMLKQ TGRDQMVVG WYHSHPGFGC WLSSVDVNTQ KSFEQLNSRA VAVVVDPIQS VKGKVVIDAF RLIDTGALIN NLEPRQTTSN T GLLNKANI ...String:
TGRDDTKETV YISSIALLKM LKHGRAGVPM EVMGLMLGEF VDDYTVNVVD VFAMPQSGTG VSVEAVDDVF QAKMMDMLKQ TGRDQMVVG WYHSHPGFGC WLSSVDVNTQ KSFEQLNSRA VAVVVDPIQS VKGKVVIDAF RLIDTGALIN NLEPRQTTSN T GLLNKANI QALIHGLNRH YYSLNIDYHK TAKETKMLMN LHKEQWQSGL KMYDYEEKEE SNLAATKSMV KIAEQYSKRI EE EKELTEE ELKTRYVGRQ DPKKHLSETA DETLENNIVS VLTAGVNSVA IK

UniProtKB: Ubiquitin carboxyl-terminal hydrolase RPN11

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Macromolecule #17: 26S proteasome regulatory subunit RPN12

MacromoleculeName: 26S proteasome regulatory subunit RPN12 / type: protein_or_peptide / ID: 17 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 31.111098 KDa
SequenceString: LTKSLSIAFE NGDYAACEKL LPPIKIELIK NNLLIPDLSI QNDIYLNDLM ITKRILEVGA LASIQTFNFD SFENYFNQLK PYYFSNNHK LSESDKKSKL ISLYLLNLLS QNNTTKFHSE LQYLDKHIKN LEDDSLLSYP IKLDRWLMEG SYQKAWDLLQ S GSQNISEF ...String:
LTKSLSIAFE NGDYAACEKL LPPIKIELIK NNLLIPDLSI QNDIYLNDLM ITKRILEVGA LASIQTFNFD SFENYFNQLK PYYFSNNHK LSESDKKSKL ISLYLLNLLS QNNTTKFHSE LQYLDKHIKN LEDDSLLSYP IKLDRWLMEG SYQKAWDLLQ S GSQNISEF DSFTDILKSA IRDEIAKNTE LSYDFLPLSN IKALLFFNNE KETEKFALER NWPIVNSKVY FNNQSKEKAD YE DEMMHEE DQKTNIIEKA MDYAISIEN

UniProtKB: 26S proteasome regulatory subunit RPN12

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Macromolecule #18: 26S proteasome regulatory subunit RPN13

MacromoleculeName: 26S proteasome regulatory subunit RPN13 / type: protein_or_peptide / ID: 18 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 14.654642 KDa
SequenceString:
VIKFRAGVCE YNEDSRLCTP IPVQGEIEIK PNEEEELGFW DFEWRPTEKP VGRELDPISL ILIPGETMWV PIKSSKSGRI FALVFSSNE RYFFWLQEKN SGNLPLNELS AKDKEIYNKM IGVLNNSS

UniProtKB: 26S proteasome regulatory subunit RPN13

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Macromolecule #19: 26S proteasome complex subunit SEM1

MacromoleculeName: 26S proteasome complex subunit SEM1 / type: protein_or_peptide / ID: 19 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 10.397102 KDa
SequenceString:
MSTDVAAAQA QSKIDLTKKK NEEINKKSLE EDDEFEDFPI DTWANGETIK SNAVTQTNIW EENWDDVEVD DDFTNELKAE LDRYKRENQ

UniProtKB: 26S proteasome complex subunit SEM1

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Macromolecule #20: 26S proteasome regulatory subunit RPN1

MacromoleculeName: 26S proteasome regulatory subunit RPN1 / type: protein_or_peptide / ID: 20 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 106.895875 KDa
SequenceString: MVDESDKKQQ TIDEQSQISP EKQTPNKKDK KKEEEEQLSE EDAKLKTDLE LLVERLKEDD SSLYEASLNA LKESIKNSTS SMTAVPKPL KFLRPTYPDL CSIYDKWTDP NLKSSLADVL SILAMTYSEN GKHDSLRYRL LSDVSDFEGW GHEYIRHLAL E IGEVYNDQ ...String:
MVDESDKKQQ TIDEQSQISP EKQTPNKKDK KKEEEEQLSE EDAKLKTDLE LLVERLKEDD SSLYEASLNA LKESIKNSTS SMTAVPKPL KFLRPTYPDL CSIYDKWTDP NLKSSLADVL SILAMTYSEN GKHDSLRYRL LSDVSDFEGW GHEYIRHLAL E IGEVYNDQ VEKDAEDETS SDGSKSDGSA ATSGFEFSKE DTLRLCLDIV PYFLKHNGEE DAVDLLLEIE SIDKLPQFVD EN TFQRVCQ YMVACVPLLP PPEDVAFLKT AYSIYLSQNE LTDAIALAVR LGEEDMIRSV FDATSDPVMH KQLAYILAAQ KTS FEYEGV QDIIGNGKLS EHFLYLAKEL NLTGPKVPED IYKSHLDNSK SVFSSAGLDS AQQNLASSFV NGFLNLGYCN DKLI VDNDN WVYKTKGDGM TSAVASIGSI YQWNLDGLQQ LDKYLYVDEP EVKAGALLGI GISASGVHDG EVEPALLLLQ DYVTN PDTK ISSAAILGLG IAFAGSKNDE VLGLLLPIAA STDLPIETAA MASLALAHVF VGTCNGDITT SIMDNFLERT AIELKT DWV RFLALALGIL YMGQGEQVDD VLETISAIEH PMTSAIEVLV GSCAYTGTGD VLLIQDLLHR LTPKNVKGEE DADEEET AE GQTNSISDFL GEQVNEPTKN EEAEIEVDEM EVDAEGEEVE VKAEITEKKN GESLEGEEIK SEEKKGKSSD KDATTDGK N DDEEEEKEAG IVDELAYAVL GIALIALGED IGKEMSLRHF GHLMHYGNEH IRRMVPLAMG IVSVSDPQMK VFDTLTRFS HDADLEVSMN SIFAMGLCGA GTNNARLAQL LRQLASYYSR EQDALFITRL AQGLLHLGKG TMTMDVFNDA HVLNKVTLAS ILTTAVGLV SPSFMLKHHQ LFYMLNAGIR PKFILALNDE GEPIKVNVRV GQAVETVGQA GRPKKITGWI TQSTPVLLNH G ERAELETD EY

UniProtKB: 26S proteasome regulatory subunit RPN1

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Macromolecule #21: 26S proteasome regulatory subunit RPN2

MacromoleculeName: 26S proteasome regulatory subunit RPN2 / type: protein_or_peptide / ID: 21 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 101.894094 KDa
SequenceString: TTAAPLLALL RENQDSVKTY ALESINNVVD QLWSEISNEL PDIEALYDDD TFSDREMAAL IASKVYYNLG EYESAVKYAL AAKDRFDID EKSQFVETIV SKSIEMYVQE ASKQYTKDEQ FYTKDIIDPK LTSIFERMIE KCLKASELKL ALGIALEGYR L DIIESALK ...String:
TTAAPLLALL RENQDSVKTY ALESINNVVD QLWSEISNEL PDIEALYDDD TFSDREMAAL IASKVYYNLG EYESAVKYAL AAKDRFDID EKSQFVETIV SKSIEMYVQE ASKQYTKDEQ FYTKDIIDPK LTSIFERMIE KCLKASELKL ALGIALEGYR L DIIESALK SKLDQDSTSE NVKIINYLLT LAITTVTNSK FRSSILRKSF DFLMNMPNCD YLTLNKVVVN LNDAGLALQL FK KLKEEND EGLSAQIAFD LVSSASQQLL EILVTELTAQ GYDPALLNIL SGLPTCDYYN TFLLNNKNID IGLLNKSKSS LDG KFSLFH TAVSVANGFM HAGTTDNSFI KANLPWLGKA QNWAKFTATA SLGVIHKGNL LEGKKVMAPY LPGSRASSRF IKGG SLYGL GLIYAGFGRD TTDYLKNIIV ENSGTSGDED VDVLLHGASL GIGLAAMGSA NIEVYEALKE VLYNDSATSG EAAAL GMGL CMLGTGKPEA IHDMFTYSQE TQHGNITRGL AVGLALINYG RQELADDLIT KMLASDESLL RYGGAFTIAL AYAGTG NNS AVKRLLHVAV SDSNDDVRRA AVIALGFVLL RDYTTVPRIV QLLSKSHNAH VRCGTAFALG IACAGKGLQS AIDVLDP LT KDPVDFVRQA AMIALSMILI QQTEKLNPQV ADINKNFLSV ITNKHQEGLA KFGACVAQGI MNAGGRNVTI QLENADTG T LDTKSVVGLV MFSQFWYWFP LAHFLSLSFT PTTVIGIRGS DQAIPKFQMN CYAKEDAFSY PRMYEEASGK EVEKVATAV LSTTARAKAR AKKTKKEKGP NEEEKKKEHE EKEKERETNK KGIKETKEND EEFYKNKYSS KPYKVDNMTR ILPQQSRYIS FIKDDRFVP VRKFKGNNGV VVLRDREPKE PVALIETVRQ MKD

UniProtKB: 26S proteasome regulatory subunit RPN2

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Macromolecule #22: 26S proteasome regulatory subunit RPN3

MacromoleculeName: 26S proteasome regulatory subunit RPN3 / type: protein_or_peptide / ID: 22 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 55.378328 KDa
SequenceString: LHHSEKKYAE EDQVQELLKV LNEISKTTLT LDPRYIWRSL KDLSSLRNQE LLNAETLCFT VNVLYPDSSS FKKNLLKFIT SNHKSSVPG SAELRNSYPA SFYSVNTEKK TIEVTAEINC FMHLLVQLFL WDSKELEQLV EFNRKVVIPN LLCYYNLRSL N LINAKLWF ...String:
LHHSEKKYAE EDQVQELLKV LNEISKTTLT LDPRYIWRSL KDLSSLRNQE LLNAETLCFT VNVLYPDSSS FKKNLLKFIT SNHKSSVPG SAELRNSYPA SFYSVNTEKK TIEVTAEINC FMHLLVQLFL WDSKELEQLV EFNRKVVIPN LLCYYNLRSL N LINAKLWF YIYLSHETLA RSSEEINSDN QNIILRSTMM KFLKIASLKH DNETKAMLIN LILRDFLNNG EVDSASDFIS KL EYPHTDV SSSLEARYFF YLSKINAIQL DYSTANEYII AAIRKAPHNS KSLGFLQQSN KLHCCIQLLM GDIPELSFFH QSN MQKSLL PYYHLTKAVK LGDLKKFTST ITKYKQLLLK DDTYQLCVRL RSNVIKTGIR IISLTYKKIS LRDICLKLNL DSEQ TVEYM VSRAIRDGVI EAKINHEDGF IETTELLNIY DSEDPQQVFD ERIKFANQLH DEYLVSMRYP EDKKTQQNEK

UniProtKB: 26S proteasome regulatory subunit RPN3

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Macromolecule #23: 26S proteasome regulatory subunit RPN5

MacromoleculeName: 26S proteasome regulatory subunit RPN5 / type: protein_or_peptide / ID: 23 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 51.341758 KDa
SequenceString: MSRDAPIKAD KDYSQILKEE FPKIDSLAQN DCNSALDQLL VLEKKTRQAS DLASSKEVLA KIVDLLASRN KWDDLNEQLT LLSKKHGQL KLSIQYMIQK VMEYLKSSKS LDLNTRISVI ETIRVVTENK IFVEVERARV TKDLVEIKKE EGKIDEAADI L CELQVETY ...String:
MSRDAPIKAD KDYSQILKEE FPKIDSLAQN DCNSALDQLL VLEKKTRQAS DLASSKEVLA KIVDLLASRN KWDDLNEQLT LLSKKHGQL KLSIQYMIQK VMEYLKSSKS LDLNTRISVI ETIRVVTENK IFVEVERARV TKDLVEIKKE EGKIDEAADI L CELQVETY GSMEMSEKIQ FILEQMELSI LKGDYSQATV LSRKILKKTF KNPKYESLKL EYYNLLVKIS LHKREYLEVA QY LQEIYQT DAIKSDEAKW KPVLSHIVYF LVLSPYGNLQ NDLIHKIQND NNLKKLESQE SLVKLFTTNE LMRWPIVQKT YEP VLNEDD LAFGGEANKH HWEDLQKRVI EHNLRVISEY YSRITLLRLN ELLDLTESQT ETYISDLVNQ GIIYAKVNRP AKIV NFEKP KNSSQLLNEW SHNVDELLEH IETIGHLITK EEIMH

UniProtKB: 26S proteasome regulatory subunit RPN5

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Macromolecule #24: 26S proteasome regulatory subunit RPN6

MacromoleculeName: 26S proteasome regulatory subunit RPN6 / type: protein_or_peptide / ID: 24 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 49.839812 KDa
SequenceString: MSLPGSKLEE ARRLVNEKQY NEAEQVYLSL LDKDSSQSSA AAGASVDDKR RNEQETSILE LGQLYVTMGA KDKLREFIPH STEYMMQFA KSKTVKVLKT LIEKFEQVPD SLDDQIFVCE KSIEFAKREK RVFLKHSLSI KLATLHYQKK QYKDSLALIN D LLREFKKL ...String:
MSLPGSKLEE ARRLVNEKQY NEAEQVYLSL LDKDSSQSSA AAGASVDDKR RNEQETSILE LGQLYVTMGA KDKLREFIPH STEYMMQFA KSKTVKVLKT LIEKFEQVPD SLDDQIFVCE KSIEFAKREK RVFLKHSLSI KLATLHYQKK QYKDSLALIN D LLREFKKL DDKPSLVDVH LLESKVYHKL RNLAKSKASL TAARTAANSI YCPTQTVAEL DLMSGILHCE DKDYKTAFSY FF ESFESYH NLTTHNSYEK ACQVLKYMLL SKIMLNLIDD VKNILNAKYT KETYQSRGID AMKAVAEAYN NRSLLDFNTA LKQ YEKELM GDELTRSHFN ALYDTLLESN LCKIIEPFEC VEISHISKII GLDTQQVEGK LSQMILDKIF YGVLDQGNGW LYVY ETPNQ DATYDSALEL VGQLNKVVDQ LFEKASVLY

UniProtKB: 26S proteasome regulatory subunit RPN6

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Macromolecule #25: 26S proteasome regulatory subunit RPN7

MacromoleculeName: 26S proteasome regulatory subunit RPN7 / type: protein_or_peptide / ID: 25 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 46.307477 KDa
SequenceString: RVPNYEVSEK AFLLTQSKVS IEQRKEAAEF VLAKIKEEEM APYYKYLCEE YLVNNGQSDL EHDEKSDSLN EWIKFDQELY NELCKKNES KIKELNEKIQ KLEEDDEGEL EQAQAWINLG EYYAQIGDKD NAEKTLGKSL SKAISTGAKI DVMLTIARLG F FYNDQLYV ...String:
RVPNYEVSEK AFLLTQSKVS IEQRKEAAEF VLAKIKEEEM APYYKYLCEE YLVNNGQSDL EHDEKSDSLN EWIKFDQELY NELCKKNES KIKELNEKIQ KLEEDDEGEL EQAQAWINLG EYYAQIGDKD NAEKTLGKSL SKAISTGAKI DVMLTIARLG F FYNDQLYV KEKLEAVNSM IEKGGDWERR NRYKTYYGIH CLAVRNFKEA AKLLVDSLAT FTSIELTSYE SIATYASVTG LF TLERTDL KSKVIDSPEL LSLISTTAAL QSISSLTISL YASDYASYFP YLLETYANVL IPCKYLNRHA DFFVREMRRK VYA QLLESY KTLSLKSMAS AFGVSVAFLD NDLGKFIPNK QLNCVIDRVN GIVETNRPDN KNAQYHLLVK QGDGLLTKLQ KYGA AVRLT

UniProtKB: 26S proteasome regulatory subunit RPN7

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Macromolecule #26: 26S proteasome regulatory subunit RPN8

MacromoleculeName: 26S proteasome regulatory subunit RPN8 / type: protein_or_peptide / ID: 26 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 34.557316 KDa
SequenceString: MSLQHEKVTI APLVLLSALD HYERTQTKEN KRCVGVILGD ANSSTIRVTN SFALPFEEDE KNSDVWFLDH NYIENMNEMC KKINAKEKL IGWYHSGPKL RASDLKINEL FKKYTQNNPL LLIVDVKQQG VGLPTDAYVA IEQVKDDGTS TEKTFLHLPC T IEAEEAEE ...String:
MSLQHEKVTI APLVLLSALD HYERTQTKEN KRCVGVILGD ANSSTIRVTN SFALPFEEDE KNSDVWFLDH NYIENMNEMC KKINAKEKL IGWYHSGPKL RASDLKINEL FKKYTQNNPL LLIVDVKQQG VGLPTDAYVA IEQVKDDGTS TEKTFLHLPC T IEAEEAEE IGVEHLLRDV RDQAAGGLSI RLTNQLKSLK GLQSKLKDVV EYLDKVINKE LPINHTILGK LQDVFNLLPN LG TPDDDEI DVENHDRINI SNNLQKALTV KTNDELMVIY ISNLVRSIIA FDDLIENKIQ NKKIQEQ

UniProtKB: 26S proteasome regulatory subunit RPN8

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Macromolecule #27: 26S proteasome regulatory subunit RPN9

MacromoleculeName: 26S proteasome regulatory subunit RPN9 / type: protein_or_peptide / ID: 27 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 45.194625 KDa
SequenceString: EIDTILSTLR MEADPSLHPL FEQFEKFYEE KLWFQLSESL TKFFDDAKST PLRLRLYDNF VSKFYDKINQ LSVVKYLLAS LKDSKDFDE SLKYLDDLKA QFQELDSKKQ RNNGSKDHGD GILLIDSEIA RTYLLKNDLV KARDLLDDLE KTLDKKDSIP L RITNSFYS ...String:
EIDTILSTLR MEADPSLHPL FEQFEKFYEE KLWFQLSESL TKFFDDAKST PLRLRLYDNF VSKFYDKINQ LSVVKYLLAS LKDSKDFDE SLKYLDDLKA QFQELDSKKQ RNNGSKDHGD GILLIDSEIA RTYLLKNDLV KARDLLDDLE KTLDKKDSIP L RITNSFYS TNSQYFKFKN DFNSFYYTSL LYLSTLEPST SITLAERQQL AYDLSISALL GDKIYNFGEL LHHPIMETIV ND SNYDWLF QLLNALTVGD FDKFDSLIKV QISKIPILAQ HESFLRQKIC LMTLIETVFV KNIRMLSFED ISKATHLPKD NVE HLVMRA ISLGLLKGSI DQVNELVTIS WVQPRIISGD QITKMKDRLV EWNDQVEKLG KKMEARGQSI WV

UniProtKB: 26S proteasome regulatory subunit RPN9

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Macromolecule #28: 26S proteasome regulatory subunit 7 homolog

MacromoleculeName: 26S proteasome regulatory subunit 7 homolog / type: protein_or_peptide / ID: 28 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 46.186387 KDa
SequenceString: AAPYAAKLKQ TENDLKDIEA RIKEKAGVKE SDTGLAPSHL WDIMGDRQRL GEEHPLQVAR CTKIIKGNGE SDETTTDNNN SGNSNSNSN QQSTDADEDD EDAKYVINLK QIAKFVVGLG ERVSPTDIEE GMRVGVDRSK YNIELPLPPR IDPSVTMMTV E EKPDVTYS ...String:
AAPYAAKLKQ TENDLKDIEA RIKEKAGVKE SDTGLAPSHL WDIMGDRQRL GEEHPLQVAR CTKIIKGNGE SDETTTDNNN SGNSNSNSN QQSTDADEDD EDAKYVINLK QIAKFVVGLG ERVSPTDIEE GMRVGVDRSK YNIELPLPPR IDPSVTMMTV E EKPDVTYS DVGGCKDQIE KLREVVELPL LSPERFATLG IDPPKGILLY GPPGTGKTLC ARAVANRTDA TFIRVIGSEL VQ KYVGEGA RMVRELFEMA RTKKACIIFF DEIDAVGGAR FDDGAGGDNE VQRTMLELIT QLDGFDPRGN IKVMFATNRP NTL DPALLR PGRIDRKVEF SLPDLEGRAN IFRIHSKSMS VERGIRWELI SRLCPNSTGA ELRSVCTEAG MFAIRARRKV ATEK DFLKA VDKVISGYKK FS

UniProtKB: 26S proteasome regulatory subunit 7 homolog

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Macromolecule #29: 26S proteasome regulatory subunit 4 homolog

MacromoleculeName: 26S proteasome regulatory subunit 4 homolog / type: protein_or_peptide / ID: 29 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 43.229602 KDa
SequenceString: TRCKLKLLRM ERIKDHLLLE EEFVSNSEIL KPFEKKQEEE KKQLEEIRGN PLSIGTLEEI IDDDHAIVTS PTMPDYYVSI LSFVDKELL EPGCSVLLHH KTMSIVGVLQ DDADPMVSVM KMDKSPTESY SDIGGLESQI QEIKESVELP LTHPELYEEM G IKPPKGVI ...String:
TRCKLKLLRM ERIKDHLLLE EEFVSNSEIL KPFEKKQEEE KKQLEEIRGN PLSIGTLEEI IDDDHAIVTS PTMPDYYVSI LSFVDKELL EPGCSVLLHH KTMSIVGVLQ DDADPMVSVM KMDKSPTESY SDIGGLESQI QEIKESVELP LTHPELYEEM G IKPPKGVI LYGAPGTGKT LLAKAVANQT SATFLRIVGS ELIQKYLGDG PRLCRQIFKV AGENAPSIVF IDEIDAIGTK RY DSNSGGE REIQRTMLEL LNQLDGFDDR GDVKVIMATN KIETLDPALI RPGRIDRKIL FENPDLSTKK KILGIHTSKM NLS EDVNLE TLVTTKDDLS GADIQAMCTE AGLLALRERR MQVTAEDFKQ AKERVMKNKV EENLEGLYL

UniProtKB: 26S proteasome regulatory subunit 4 homolog

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Macromolecule #30: 26S proteasome regulatory subunit 6B homolog

MacromoleculeName: 26S proteasome regulatory subunit 6B homolog / type: protein_or_peptide / ID: 30 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 44.353523 KDa
SequenceString: NNNSALSNVN SDIYFKLKKL EKEYELLTLQ EDYIKDEQRH LKRELKRAQE EVKRIQSVPL VIGQFLEPID QNTGIVSSTT GMSYVVRIL STLDRELLKP SMSVALHRHS NALVDILPPD SDSSISVMGE NEKPDVTYAD VGGLDMQKQE IREAVELPLV Q ADLYEQIG ...String:
NNNSALSNVN SDIYFKLKKL EKEYELLTLQ EDYIKDEQRH LKRELKRAQE EVKRIQSVPL VIGQFLEPID QNTGIVSSTT GMSYVVRIL STLDRELLKP SMSVALHRHS NALVDILPPD SDSSISVMGE NEKPDVTYAD VGGLDMQKQE IREAVELPLV Q ADLYEQIG IDPPRGVLLY GPPGTGKTML VKAVANSTKA AFIRVNGSEF VHKYLGEGPR MVRDVFRLAR ENAPSIIFID EV DSIATKR FDAQTGSDRE VQRILIELLT QMDGFDQSTN VKVIMATNRA DTLDPALLRP GRLDRKIEFP SLRDRRERRL IFG TIASKM SLAPEADLDS LIIRNDSLSG AVIAAIMQEA GLRAVRKNRY VILQSDLEEA YATQVKTDNT VDKFDFYK

UniProtKB: 26S proteasome regulatory subunit 6B homolog

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Macromolecule #31: 26S proteasome subunit RPT4

MacromoleculeName: 26S proteasome subunit RPT4 / type: protein_or_peptide / ID: 31 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 43.931473 KDa
SequenceString: EQEAHNKALN QFKRKLLEHR RYDDQLKQRR QNIRDLEKLY DKTENDIKAL QSIGQLIGEV MKELSEEKYI VKASSGPRYI VGVRNSVDR SKLKKGVRVT LDITTLTIMR ILPRETDPLV YNMTSFEQGE ITFDGIGGLT EQIRELREVI ELPLKNPEIF Q RVGIKPPK ...String:
EQEAHNKALN QFKRKLLEHR RYDDQLKQRR QNIRDLEKLY DKTENDIKAL QSIGQLIGEV MKELSEEKYI VKASSGPRYI VGVRNSVDR SKLKKGVRVT LDITTLTIMR ILPRETDPLV YNMTSFEQGE ITFDGIGGLT EQIRELREVI ELPLKNPEIF Q RVGIKPPK GVLLYGPPGT GKTLLAKAVA ATIGANFIFS PASGIVDKYI GESARIIREM FAYAKEHEPC IIFMDEVDAI GG RRFSEGT SADREIQRTL MELLTQMDGF DNLGQTKIIM ATNRPDTLDP ALLRPGRLDR KVEIPLPNEA GRLEIFKIHT AKV KKTGEF DFEAAVKMSD GFNGADIRNC ATEAGFFAIR DDRDHINPDD LMKAVRKVAE VKKLEGTIEY QK

UniProtKB: 26S proteasome subunit RPT4

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Macromolecule #32: 26S proteasome regulatory subunit 6A

MacromoleculeName: 26S proteasome regulatory subunit 6A / type: protein_or_peptide / ID: 32 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 46.902141 KDa
SequenceString: GDDELDQEIL NLSTQELQTR AKLLDNEIRI FRSELQRLSH ENNVMLEKIK DNKEKIKNNR QLPYLVANVV EVMDMNEIED KENSESTTQ GGNVNLDNTA VGKAAVVKTS SRQTVFLPMV GLVDPDKLKP NDLVGVNKDS YLILDTLPSE FDSRVKAMEV D EKPTETYS ...String:
GDDELDQEIL NLSTQELQTR AKLLDNEIRI FRSELQRLSH ENNVMLEKIK DNKEKIKNNR QLPYLVANVV EVMDMNEIED KENSESTTQ GGNVNLDNTA VGKAAVVKTS SRQTVFLPMV GLVDPDKLKP NDLVGVNKDS YLILDTLPSE FDSRVKAMEV D EKPTETYS DVGGLDKQIE ELVEAIVLPM KRADKFKDMG IRAPKGALMY GPPGTGKTLL ARACAAQTNA TFLKLAAPQL VQ MYIGEGA KLVRDAFALA KEKAPTIIFI DELDAIGTKR FDSEKSGDRE VQRTMLELLN QLDGFSSDDR VKVLAATNRV DVL DPALLR SGRLDRKIEF PLPSEDSRAQ ILQIHSRKMT TDDDINWQEL ARSTDEFNGA QLKAVTVEAG MIALRNGQSS VKHE DFVEG ISEVQARKSK SVSFYA

UniProtKB: 26S proteasome regulatory subunit 6A

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Macromolecule #33: 26S proteasome regulatory subunit 8 homolog

MacromoleculeName: 26S proteasome regulatory subunit 8 homolog / type: protein_or_peptide / ID: 33 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (yeast)
Molecular weightTheoretical: 45.342742 KDa
SequenceString: MTAAVTSSNI VLETHESGIK PYFEQKIQET ELKIRSKTEN VRRLEAQRNA LNDKVRFIKD ELRLLQEPGS YVGEVIKIVS DKKVLVKVQ PEGKYIVDVA KDINVKDLKA SQRVCLRSDS YMLHKVLENK ADPLVSLMMV EKVPDSTYDM VGGLTKQIKE I KEVIELPV ...String:
MTAAVTSSNI VLETHESGIK PYFEQKIQET ELKIRSKTEN VRRLEAQRNA LNDKVRFIKD ELRLLQEPGS YVGEVIKIVS DKKVLVKVQ PEGKYIVDVA KDINVKDLKA SQRVCLRSDS YMLHKVLENK ADPLVSLMMV EKVPDSTYDM VGGLTKQIKE I KEVIELPV KHPELFESLG IAQPKGVILY GPPGTGKTLL ARAVAHHTDC KFIRVSGAEL VQKYIGEGSR MVRELFVMAR EH APSIIFM DEIDSIGSTR VEGSGGGDSE VQRTMLELLN QLDGFETSKN IKIIMATNRL DILDPALLRP GRIDRKIEFP PPS VAARAE ILRIHSRKMN LTRGINLRKV AEKMNGCSGA DVKGVCTEAG MYALRERRIH VTQEDFELAV GKVMNKNQET AISV AKLFK

UniProtKB: 26S proteasome regulatory subunit 8 homolog

+
Macromolecule #34: ADENOSINE-5'-DIPHOSPHATE

MacromoleculeName: ADENOSINE-5'-DIPHOSPHATE / type: ligand / ID: 34 / Number of copies: 2 / Formula: ADP
Molecular weightTheoretical: 427.201 Da
Chemical component information

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM

+
Macromolecule #35: MAGNESIUM ION

MacromoleculeName: MAGNESIUM ION / type: ligand / ID: 35 / Number of copies: 6 / Formula: MG
Molecular weightTheoretical: 24.305 Da

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Macromolecule #36: ADENOSINE-5'-TRIPHOSPHATE

MacromoleculeName: ADENOSINE-5'-TRIPHOSPHATE / type: ligand / ID: 36 / Number of copies: 4 / Formula: ATP
Molecular weightTheoretical: 507.181 Da
Chemical component information

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

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Experimental details

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Structure determination

Methodcryo EM
Processingsingle particle reconstruction
Aggregation stateparticle

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Sample preparation

BufferpH: 7.4
VitrificationCryogen name: ETHANE-PROPANE

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Electron microscopy

MicroscopeFEI TITAN KRIOS
Image recordingFilm or detector model: GATAN K2 SUMMIT (4k x 4k) / Average electron dose: 35.0 e/Å2
Electron beamAcceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN
Electron opticsIllumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELD
Experimental equipment
Model: Titan Krios / Image courtesy: FEI Company

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Image processing

Startup modelType of model: PDB ENTRY
PDB model - PDB ID:

4cr2

Final reconstructionResolution.type: BY AUTHOR / Resolution: 5.4 Å / Resolution method: FSC 0.143 CUT-OFF / Number images used: 292279
Initial angle assignmentType: PROJECTION MATCHING
Final angle assignmentType: PROJECTION MATCHING

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