登録情報 | データベース: PDB / ID: 3u2o |
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タイトル | Dihydroorotate Dehydrogenase (DHODH) crystal structure in complex with small molecule inhibitor |
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要素 | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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キーワード | OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / DHODH / DEHYDROGENASE / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane ...pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane / mitochondrion / nucleoplasm / cytosol類似検索 - 分子機能 Dihydroorotate dehydrogenase, class 2 / Dihydroorotate dehydrogenase signature 1. / Dihydroorotate dehydrogenase signature 2. / Dihydroorotate dehydrogenase, conserved site / : / Dihydroorotate dehydrogenase domain / Dihydroorotate dehydrogenase / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel ...Dihydroorotate dehydrogenase, class 2 / Dihydroorotate dehydrogenase signature 1. / Dihydroorotate dehydrogenase signature 2. / Dihydroorotate dehydrogenase, conserved site / : / Dihydroorotate dehydrogenase domain / Dihydroorotate dehydrogenase / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel / Alpha-Beta Barrel / Alpha Beta類似検索 - ドメイン・相同性 Chem-03U / ACETATE ION / FLAVIN MONONUCLEOTIDE / OROTIC ACID / Dihydroorotate dehydrogenase (quinone), mitochondrial類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.18 Å |
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データ登録者 | Lozoya, E. / Segarra, V. / Erra, M. / Wenzkowski, C. / Jestel, A. / Krapp, S. / Blaesse, M. |
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引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2011 タイトル: Biaryl analogues of teriflunomide as potent DHODH inhibitors. 著者: Erra, M. / Moreno, I. / Sanahuja, J. / Andres, M. / Reinoso, R.F. / Lozoya, E. / Pizcueta, P. / Godessart, N. / Castro-Palomino, J.C. |
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履歴 | 登録 | 2011年10月4日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2011年11月16日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2012年9月5日 | Group: Database references |
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改定 1.2 | 2023年9月13日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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