Entry Database : PDB / ID : 4zmg Structure visualization Downloads & linksTitle Crystal structure of Human Dihydroorotate Dehydrogenase (DHODH) with DH03A338 ComponentsDihydroorotate dehydrogenase (quinone), mitochondrial Details Keywords OXIDOREDUCTASE/OXIDOREDUCTASE INHIBITOR / oxidoreductase / FMN binding / mitochondria inner membrane / OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complexFunction / homology Function and homology informationFunction Domain/homology Component
pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane ... pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane / mitochondrion / nucleoplasm / plasma membrane / cytosol Similarity search - Function Dihydroorotate dehydrogenase, class 2 / Dihydroorotate dehydrogenase signature 1. / Dihydroorotate dehydrogenase signature 2. / Dihydroorotate dehydrogenase, conserved site / Dihydroorotate dehydrogenase domain / Dihydroorotate dehydrogenase / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel / Alpha-Beta Barrel / Alpha Beta Similarity search - Domain/homology Chem-4R5 / ACETATE ION / FLAVIN MONONUCLEOTIDE / OROTIC ACID / Dihydroorotate dehydrogenase (quinone), mitochondrial Similarity search - ComponentBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.9 Å DetailsAuthors Ren, X.L. / Zhu, J.S. / Zhu, L.L. / Li, H.L. Funding support China, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health 81302697 China
CitationJournal : To Be Published Title : Crystal structure of Human Dihydroorotate Dehydrogenase (DHODH) with DH03A338Authors : Ren, X.L. / Zhu, J.S. / Zhu, L.L. / Li, H.L. History Deposition May 4, 2015 Deposition site : RCSB / Processing site : PDBJRevision 1.0 May 4, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Nov 8, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_oper_list Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_oper_list.symmetry_operation
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