登録情報 | データベース: PDB / ID: 3s7l |
---|
タイトル | Pyrazolyl and Thienyl Aminohydantoins as Potent BACE1 Inhibitors |
---|
要素 | Beta-secretase 1 |
---|
キーワード | HYDROLASE/HYDROLASE INHIBITOR / Aspartyl protease / Disulfide bond / Protease / HYDROLASE-HYDROLASE INHIBITOR complex |
---|
機能・相同性 | 機能・相同性情報
memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition ...memapsin 2 / Golgi-associated vesicle lumen / signaling receptor ligand precursor processing / beta-aspartyl-peptidase activity / amyloid precursor protein catabolic process / amyloid-beta formation / membrane protein ectodomain proteolysis / cellular response to manganese ion / amyloid-beta metabolic process / prepulse inhibition / detection of mechanical stimulus involved in sensory perception of pain / protein serine/threonine kinase binding / cellular response to copper ion / presynaptic modulation of chemical synaptic transmission / hippocampal mossy fiber to CA3 synapse / multivesicular body / response to lead ion / trans-Golgi network / protein processing / recycling endosome / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / synaptic vesicle / late endosome / peptidase activity / amyloid-beta binding / endopeptidase activity / amyloid fibril formation / aspartic-type endopeptidase activity / lysosome / early endosome / endosome membrane / endosome / membrane raft / Amyloid fiber formation / endoplasmic reticulum lumen / axon / neuronal cell body / dendrite / Golgi apparatus / enzyme binding / cell surface / proteolysis / membrane / plasma membrane類似検索 - 分子機能 Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site ...Beta-secretase BACE1 / Beta-secretase BACE / Memapsin-like / Eukaryotic aspartyl protease / Aspartic peptidase A1 family / Peptidase family A1 domain / Peptidase family A1 domain profile. / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly Beta類似検索 - ドメイン・相同性 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / 分子置換 / 解像度: 2.162 Å |
---|
データ登録者 | Chopra, R. / Olland, A. / Svenson, K. |
---|
引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2011 タイトル: New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: Exploring the S2' region. 著者: Malamas, M.S. / Erdei, J. / Gunawan, I. / Barnes, K. / Hui, Y. / Johnson, M. / Robichaud, A. / Zhou, P. / Yan, Y. / Solvibile, W. / Turner, J. / Fan, K.Y. / Chopra, R. / Bard, J. / Pangalos, M.N. |
---|
履歴 | 登録 | 2011年5月26日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2011年8月31日 | Provider: repository / タイプ: Initial release |
---|
|
---|