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-Structure paper
Title | New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: Exploring the S2' region. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 21, Page 5164-5170, Year 2011 |
Publish date | May 26, 2011 (structure data deposition date) |
![]() | Malamas, M.S. / Erdei, J. / Gunawan, I. / Barnes, K. / Hui, Y. / Johnson, M. / Robichaud, A. / Zhou, P. / Yan, Y. / Solvibile, W. ...Malamas, M.S. / Erdei, J. / Gunawan, I. / Barnes, K. / Hui, Y. / Johnson, M. / Robichaud, A. / Zhou, P. / Yan, Y. / Solvibile, W. / Turner, J. / Fan, K.Y. / Chopra, R. / Bard, J. / Pangalos, M.N. |
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Methods | X-ray diffraction |
Resolution | 2.162 - 2.2 Å |
Structure data | ![]() PDB-3s7l: ![]() PDB-3s7m: |
Chemicals | ![]() ChemComp-591: ![]() ChemComp-HOH: ![]() ChemComp-532: |
Source |
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![]() | HYDROLASE/HYDROLASE INHIBITOR / Aspartyl protease / Disulfide bond / Protease / HYDROLASE-HYDROLASE INHIBITOR complex / Endoplasmic reticulum / Endosome / Glycoprotein / Golgi apparatus / Membrane / Transmembrane |