登録情報 データベース : PDB / ID : 3hqz 構造の表示 ダウンロードとリンクタイトル Discovery of novel inhibitors of PDE10A 要素cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 詳細 キーワード HYDROLASE/HYDROLASE INHIBITOR / Phosphodiesterase 10A PDE 10A PDE10 inhibitors / Allosteric enzyme / Alternative splicing / cAMP / cAMP-binding / cGMP / cGMP-binding / Cytoplasm / Hydrolase / Magnesium / Metal-binding / Nucleotide-binding / Zinc / HYDROLASE-HYDROLASE INHIBITOR COMPLEX機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
cyclic-nucleotide phosphodiesterase activity / cGMP effects / G alpha (s) signalling events / extrinsic component of postsynaptic density membrane / regulation of protein kinase A signaling / negative regulation of cAMP-mediated signaling / regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway / 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity / 3',5'-cyclic-nucleotide phosphodiesterase / negative regulation of cGMP-mediated signaling ... cyclic-nucleotide phosphodiesterase activity / cGMP effects / G alpha (s) signalling events / extrinsic component of postsynaptic density membrane / regulation of protein kinase A signaling / negative regulation of cAMP-mediated signaling / regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway / 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity / 3',5'-cyclic-nucleotide phosphodiesterase / negative regulation of cGMP-mediated signaling / cGMP catabolic process / cAMP catabolic process / 3',5'-cyclic-nucleotide phosphodiesterase activity / cGMP binding / 3',5'-cyclic-GMP phosphodiesterase activity / 3',5'-cyclic-AMP phosphodiesterase activity / cAMP binding / cAMP-mediated signaling / perikaryon / neuronal cell body / glutamatergic synapse / synapse / metal ion binding / cytosol 類似検索 - 分子機能 Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. / 3'5'-cyclic nucleotide phosphodiesterase domain profile. / GAF domain ... Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. / 3'5'-cyclic nucleotide phosphodiesterase domain profile. / GAF domain / Domain present in phytochromes and cGMP-specific phosphodiesterases. / GAF domain / GAF-like domain superfamily / Metal dependent phosphohydrolases with conserved 'HD' motif. / HD/PDEase domain / Orthogonal Bundle / Mainly Alpha 類似検索 - ドメイン・相同性 Chem-PF8 / cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A 類似検索 - 構成要素生物種 Rattus norvegicus (ドブネズミ)手法 X線回折 / 分子置換 / 解像度 : 1.7 Å 詳細データ登録者 Pandit, J. / Marr, E.S. 引用ジャーナル : J.Med.Chem. / 年 : 2009タイトル: Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF- ... タイトル : Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia著者: Verhoest, P.R. / Chapin, D.S. / Corman, M. / Fonseca, K. / Harms, J.F. / Hou, X. / Marr, E.S. / Menniti, F.S. / Nelson, F. / O'Connor, R. / Pandit, J. / Proulx-Lafrance, C. / Schmidt, A.W. / ... 著者 : Verhoest, P.R. / Chapin, D.S. / Corman, M. / Fonseca, K. / Harms, J.F. / Hou, X. / Marr, E.S. / Menniti, F.S. / Nelson, F. / O'Connor, R. / Pandit, J. / Proulx-Lafrance, C. / Schmidt, A.W. / Schmidt, C.J. / Suiciak, J.A. / Liras, S. 履歴 登録 2009年6月8日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2009年8月4日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2023年9月6日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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