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Title | Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia |
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Journal, issue, pages | J. Med. Chem., Vol. 52, Page 5188-5196, Year 2009 |
Publish date | Jun 8, 2009 (structure data deposition date) |
Authors | Verhoest, P.R. / Chapin, D.S. / Corman, M. / Fonseca, K. / Harms, J.F. / Hou, X. / Marr, E.S. / Menniti, F.S. / Nelson, F. / O'Connor, R. ...Verhoest, P.R. / Chapin, D.S. / Corman, M. / Fonseca, K. / Harms, J.F. / Hou, X. / Marr, E.S. / Menniti, F.S. / Nelson, F. / O'Connor, R. / Pandit, J. / Proulx-Lafrance, C. / Schmidt, A.W. / Schmidt, C.J. / Suiciak, J.A. / Liras, S. |
External links | J. Med. Chem. / PubMed:19630403 |
Methods | X-ray diffraction |
Resolution | 1.53 - 2 Å |
Structure data | PDB-3hqw: PDB-3hqy: PDB-3hqz: PDB-3hr1: |
Chemicals | ChemComp-ZN: ChemComp-MG: ChemComp-PF4: ChemComp-HOH: ChemComp-SO4: ChemComp-PF6: ChemComp-PF8: ChemComp-PF9: |
Source |
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Keywords | HYDROLASE/HYDROLASE INHIBITOR / Phosphodiesterase 10A PDE10A PDE inhibitors / Allosteric enzyme / Alternative splicing / cAMP / cAMP-binding / cGMP / cGMP-binding / Cytoplasm / Hydrolase / Magnesium / Metal-binding / Nucleotide-binding / Zinc / HYDROLASE-HYDROLASE INHIBITOR COMPLEX / Phosphodiesterase 10A PDE 10A PDE10 inhibitors / Phosphodiesterase 10A / PDE 10A / PDE10 inhibitors |