登録情報 | データベース: PDB / ID: 2zas |
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タイトル | Crystal structure of human estrogen-related receptor gamma ligand binding domain complex with 4-alpha-cumylphenol, a bisphenol A derivative |
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要素 | Estrogen-related receptor gamma |
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キーワード | TRANSCRIPTION / ERR gamma / BPA / 4-alpha-cumylphenol / nuclear receptor / Activator / DNA-binding / Metal-binding / Nucleus / Transcription regulation / Zinc-finger |
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機能・相同性 | 機能・相同性情報
AF-2 domain binding / nuclear steroid receptor activity / retinoic acid receptor signaling pathway / estrogen response element binding / nuclear receptor-mediated steroid hormone signaling pathway / steroid binding / Nuclear Receptor transcription pathway / nuclear receptor activity / sequence-specific double-stranded DNA binding / positive regulation of cold-induced thermogenesis ...AF-2 domain binding / nuclear steroid receptor activity / retinoic acid receptor signaling pathway / estrogen response element binding / nuclear receptor-mediated steroid hormone signaling pathway / steroid binding / Nuclear Receptor transcription pathway / nuclear receptor activity / sequence-specific double-stranded DNA binding / positive regulation of cold-induced thermogenesis / DNA-binding transcription activator activity, RNA polymerase II-specific / DNA-binding transcription factor activity, RNA polymerase II-specific / chromatin / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / zinc ion binding / nucleoplasm / identical protein binding類似検索 - 分子機能 Oestrogen-related receptor / Retinoic acid receptor / Estrogen receptor/oestrogen-related receptor / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. ...Oestrogen-related receptor / Retinoic acid receptor / Estrogen receptor/oestrogen-related receptor / Retinoid X Receptor / Retinoid X Receptor / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 4-(1-methyl-1-phenylethyl)phenol / Estrogen-related receptor gamma類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2 Å |
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データ登録者 | Matsushima, A. / Kakuta, Y. / Teramoto, T. / Shimohigashi, Y. |
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引用 | ジャーナル: Biochem.Biophys.Res.Commun. / 年: 2008 タイトル: ERRgamma tethers strongly bisphenol A and 4-alpha-cumylphenol in an induced-fit manner 著者: Matsushima, A. / Teramoto, T. / Okada, H. / Liu, X. / Tokunaga, T. / Kakuta, Y. / Shimohigashi, Y. |
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履歴 | 登録 | 2007年10月9日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2008年10月7日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Non-polymer description / Version format compliance |
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改定 1.2 | 2017年10月11日 | Group: Refinement description / カテゴリ: software / Item: _software.name |
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改定 1.3 | 2023年11月1日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI ..._chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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