登録情報 | データベース: EMDB / ID: EMD-22919 |
---|
タイトル | Full-length human mitochondrial Hsp90 (TRAP1) SpyCatcher/SpyTag-SdhB heterodimer in the presence of AMP-PNP |
---|
マップデータ | |
---|
試料 | - 複合体: Full-length human mitochondrial Hsp90 (TRAP1) SpyCatcher/SpyTag-SdhB heterodimer in the presence of AMP-PNP
- タンパク質・ペプチド: Heat shock protein 75 kDa, mitochondrial, SpyCatcher
- タンパク質・ペプチド: Heat shock protein 75 kDa, mitochondrial, SpyTag, Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (chimera)
- リガンド: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
- リガンド: MAGNESIUM ION
- リガンド: POTASSIUM ION
|
---|
キーワード | Hsp90 / CHAPERONE / TRAP1 / SdhB / mitochondria / SpyTag / SpyCatcher |
---|
機能・相同性 | 機能・相同性情報
translational attenuation / negative regulation of cellular respiration / 酸化還元酵素; CH-OHの結合に対し酸化酵素として働く; キノンあるいはその類似化合物を用いる / : / mitochondrial electron transport, succinate to ubiquinone / Citric acid cycle (TCA cycle) / succinate dehydrogenase / succinate dehydrogenase (quinone) activity / Maturation of TCA enzymes and regulation of TCA cycle / tumor necrosis factor receptor binding ...translational attenuation / negative regulation of cellular respiration / 酸化還元酵素; CH-OHの結合に対し酸化酵素として働く; キノンあるいはその類似化合物を用いる / : / mitochondrial electron transport, succinate to ubiquinone / Citric acid cycle (TCA cycle) / succinate dehydrogenase / succinate dehydrogenase (quinone) activity / Maturation of TCA enzymes and regulation of TCA cycle / tumor necrosis factor receptor binding / negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide / 3 iron, 4 sulfur cluster binding / ubiquinone binding / Respiratory electron transport / negative regulation of reactive oxygen species biosynthetic process / chaperone-mediated protein folding / tricarboxylic acid cycle / respiratory electron transport chain / proton motive force-driven mitochondrial ATP synthesis / cell periphery / ATP-dependent protein folding chaperone / mitochondrial membrane / aerobic respiration / mitochondrial intermembrane space / 2 iron, 2 sulfur cluster binding / unfolded protein binding / protein folding / 4 iron, 4 sulfur cluster binding / electron transfer activity / mitochondrial inner membrane / mitochondrial matrix / protein kinase binding / ATP hydrolysis activity / mitochondrion / RNA binding / nucleoplasm / ATP binding / membrane / metal ion binding / plasma membrane類似検索 - 分子機能 : / 4Fe-4S dicluster domain / Succinate dehydrogenase/fumarate reductase iron-sulphur protein / Succinate dehydogenase/fumarate reductase N-terminal / 2Fe-2S iron-sulfur cluster binding domain / Alpha-helical ferredoxin / 2Fe-2S ferredoxin, iron-sulphur binding site / 2Fe-2S ferredoxin-type iron-sulfur binding region signature. / HSP90, C-terminal domain / Heat shock protein Hsp90, N-terminal ...: / 4Fe-4S dicluster domain / Succinate dehydrogenase/fumarate reductase iron-sulphur protein / Succinate dehydogenase/fumarate reductase N-terminal / 2Fe-2S iron-sulfur cluster binding domain / Alpha-helical ferredoxin / 2Fe-2S ferredoxin, iron-sulphur binding site / 2Fe-2S ferredoxin-type iron-sulfur binding region signature. / HSP90, C-terminal domain / Heat shock protein Hsp90, N-terminal / Heat shock protein Hsp90 family / Hsp90 protein / Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase / Beta-grasp domain superfamily / 2Fe-2S ferredoxin-type iron-sulfur binding domain profile. / 2Fe-2S ferredoxin-type iron-sulfur binding domain / 2Fe-2S ferredoxin-like superfamily / 4Fe-4S ferredoxin, iron-sulphur binding, conserved site / 4Fe-4S ferredoxin-type iron-sulfur binding region signature. / 4Fe-4S ferredoxin-type iron-sulfur binding domain profile. / 4Fe-4S ferredoxin-type, iron-sulphur binding domain / Histidine kinase-like ATPases / Histidine kinase/HSP90-like ATPase / Histidine kinase/HSP90-like ATPase superfamily / Ribosomal protein S5 domain 2-type fold類似検索 - ドメイン・相同性 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial / Heat shock protein 75 kDa, mitochondrial類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) / synthetic construct (人工物) |
---|
手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.1 Å |
---|
データ登録者 | Liu YX / Agard DA |
---|
資金援助 | 米国, 6件 Organization | Grant number | 国 |
---|
Howard Hughes Medical Institute (HHMI) | | 米国 | American Heart Association | 18POST33990362 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R35GM118099 | 米国 | National Institutes of Health/National Cancer Institute (NIH/NCI) | U54CA209891 | 米国 | National Institutes of Health/National Institute of Mental Health (NIH/NIMH) | U01MH115747 | 米国 | National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | U19AI135990 | 米国 |
|
---|
引用 | ジャーナル: To Be Published タイトル: Cryo-EM analysis of human mitochondrial Hsp90 in multiple tetrameric states 著者: Liu YX / Agard DA / Elnatan D / Sun M / Larson AG |
---|
履歴 | 登録 | 2020年11月1日 | - |
---|
ヘッダ(付随情報) 公開 | 2021年11月3日 | - |
---|
マップ公開 | 2021年11月3日 | - |
---|
更新 | 2024年5月29日 | - |
---|
現状 | 2024年5月29日 | 処理サイト: RCSB / 状態: 公開 |
---|
|
---|