登録情報 データベース : PDB / ID : 1dcy 構造の表示 ダウンロードとリンクタイトル CRYSTAL STRUCTURE OF HUMAN S-PLA2 IN COMPLEX WITH INDOLE 3 ACTIVE SITE INHIBITOR 要素PHOSPHOLIPASE A2 詳細 キーワード HYDROLASE/HYDROLASE INHIBITOR / S-PLA2 / STRUCTURE-BASED DRUG DESIGN / HYDROLASE-HYDROLASE INHIBITOR complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
regulation of neutrophil activation / phosphatidylethanolamine metabolic process / phosphatidic acid metabolic process / Acyl chain remodelling of PG / intestinal stem cell homeostasis / Acyl chain remodelling of PC / Acyl chain remodelling of PI / Acyl chain remodelling of PS / Acyl chain remodelling of PE / Synthesis of PA ... regulation of neutrophil activation / phosphatidylethanolamine metabolic process / phosphatidic acid metabolic process / Acyl chain remodelling of PG / intestinal stem cell homeostasis / Acyl chain remodelling of PC / Acyl chain remodelling of PI / Acyl chain remodelling of PS / Acyl chain remodelling of PE / Synthesis of PA / phosphatidylcholine metabolic process / phospholipase A2 activity / positive regulation of macrophage derived foam cell differentiation / low-density lipoprotein particle remodeling / calcium-dependent phospholipase A2 activity / phospholipase A2 / Antimicrobial peptides / arachidonic acid secretion / phospholipid metabolic process / lipid catabolic process / negative regulation of T cell proliferation / secretory granule / phospholipid binding / positive regulation of inflammatory response / killing of cells of another organism / mitochondrial outer membrane / positive regulation of ERK1 and ERK2 cascade / defense response to Gram-positive bacterium / inflammatory response / calcium ion binding / endoplasmic reticulum membrane / perinuclear region of cytoplasm / endoplasmic reticulum / extracellular space / extracellular exosome / extracellular region / plasma membrane 類似検索 - 分子機能 Phospholipase A2, aspartic acid active site / Phospholipase A2 aspartic acid active site. / Phospholipase A2 / Phospholipase A2, histidine active site / Phospholipase A2 histidine active site. / Phospholipase A2 / Phospholipase A2 domain / Phospholipase A2 / Phospholipase A2 / Phospholipase A2 domain ... Phospholipase A2, aspartic acid active site / Phospholipase A2 aspartic acid active site. / Phospholipase A2 / Phospholipase A2, histidine active site / Phospholipase A2 histidine active site. / Phospholipase A2 / Phospholipase A2 domain / Phospholipase A2 / Phospholipase A2 / Phospholipase A2 domain / Phospholipase A2 domain superfamily / Up-down Bundle / Mainly Alpha 類似検索 - ドメイン・相同性 Chem-I3N / Phospholipase A2, membrane associated 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / 解像度 : 2.7 Å 詳細データ登録者 Chirgadze, N.Y. / Schevitz, R.W. / Wery, J.-P. 引用ジャーナル : Nat.Struct.Biol. / 年 : 1995タイトル : Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2.著者: Schevitz, R.W. / Bach, N.J. / Carlson, D.G. / Chirgadze, N.Y. / Clawson, D.K. / D Dillard, R. / Draheim, S.D. / Hartley, L.W. / Jones, N.D. / Mihelich, E.D. / L Olkowski, J. / Snyder, D.W. / ... 著者 : Schevitz, R.W. / Bach, N.J. / Carlson, D.G. / Chirgadze, N.Y. / Clawson, D.K. / D Dillard, R. / Draheim, S.D. / Hartley, L.W. / Jones, N.D. / Mihelich, E.D. / L Olkowski, J. / Snyder, D.W. / Dand, S.C. / Wery, J.-P. 履歴 登録 1999年11月5日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 1999年11月12日 Provider : repository / タイプ : Initial release改定 1.1 2008年4月27日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance
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