Biotechnology and Biological Sciences Research Council (BBSRC)
BBSRC: B5R00550 B500.01
英国
National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID)
P50AI150481
米国
Wellcome Trust
206422/Z/17/Z
英国
Biotechnology and Biological Sciences Research Council (BBSRC)
BB/S003339/1
英国
European Research Council (ERC)
101021133
European Union
引用
ジャーナル: mBio / 年: 2023 タイトル: Structure of the native chemotaxis core signaling unit from phage E-protein lysed cells. 著者: C Keith Cassidy / Zhuan Qin / Thomas Frosio / Khoosheh Gosink / Zhengyi Yang / Mark S P Sansom / Phillip J Stansfeld / John S Parkinson / Peijun Zhang / 要旨: Bacterial chemotaxis is a ubiquitous behavior that enables cell movement toward or away from specific chemicals. It serves as an important model for understanding cell sensory signal transduction and ...Bacterial chemotaxis is a ubiquitous behavior that enables cell movement toward or away from specific chemicals. It serves as an important model for understanding cell sensory signal transduction and motility. Characterization of the molecular mechanisms underlying chemotaxis is of fundamental interest and requires a high-resolution structural picture of the sensing machinery, the chemosensory array. In this study, we combine cryo-electron tomography and molecular simulation to present the complete structure of the core signaling unit, the basic building block of chemosensory arrays, from . Our results provide new insight into previously poorly-resolved regions of the complex and offer a structural basis for designing new experiments to test mechanistic hypotheses.