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TitleStomatin encapsulates aquaporin-1 and urea transporter-B in the erythrocyte membrane.
Journal, issue, pagesSci Adv, Vol. 12, Issue 14, Page eaec1721, Year 2026
Publish dateApr 3, 2026
AuthorsFrancesca Vallese / Huan Li / Lucia Barazzuol / Tito Calì / Oliver B Clarke /
PubMed AbstractStomatin is a ubiquitous and highly expressed protein in erythrocytes, which associates with cholesterol-rich microdomains in the plasma membrane and is known to regulate the activity of multiple ion ...Stomatin is a ubiquitous and highly expressed protein in erythrocytes, which associates with cholesterol-rich microdomains in the plasma membrane and is known to regulate the activity of multiple ion channels and transporters, but the structural basis of association with stomatin targets remains unknown. Here, we describe high-resolution structures of multiple stomatin complexes with endogenous binding partners isolated from human erythrocyte membranes, revealing that stomatin specifically associates with two membrane proteins involved in water transport and cell volume regulation, aquaporin-1 and the urea transporter SLC14A1. Together, our results reveal the structural basis of stomatin oligomerization, membrane association, and target recruitment and identify a putative role for stomatin in the regulation of osmotic balance in the erythrocyte.
External linksSci Adv / PubMed:41921000 / PubMed Central
MethodsEM (single particle)
Resolution2.0 - 3.1 Å
Structure data

73881

9z7u

EMDB-73881, PDB-9z7u:
Human Stomatin - C8 Symmetry
Method: EM (single particle) / Resolution: 2.0 Å

74046

9zcz

EMDB-74046, PDB-9zcz:
C4 local refinement of stomatin-bound aquaporin (human)
Method: EM (single particle) / Resolution: 2.3 Å

74047

9zd0

EMDB-74047, PDB-9zd0:
C3 local refinement of Urea Transporter B (SLC14A1) bound to human stomatin oligomer
Method: EM (single particle) / Resolution: 2.8 Å

74049

9zd2

EMDB-74049, PDB-9zd2:
C1 local refinement of aquaporin 1 bound to endogenous human stomatin
Method: EM (single particle) / Resolution: 3.1 Å

74052

9zd5

EMDB-74052, PDB-9zd5:
Human Stomatin - intramembrane region
Method: EM (single particle) / Resolution: 2.2 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-CLR:
CHOLESTEROL

ChemComp-PLM:
PALMITIC ACID

ChemComp-PTY:
PHOSPHATIDYLETHANOLAMINE / phospholipid*YM

ChemComp-PLC:
DIUNDECYL PHOSPHATIDYL CHOLINE / phospholipid*YM

ChemComp-S1P:
(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate

Source
  • homo sapiens (human)
KeywordsMEMBRANE PROTEIN / Oligomer / C8 symmetry / scaffold / TRANSPORT PROTEIN / aquaporin / SPFH / solute carrier / SLC / intramembrane region

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