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Structure paper

TitleConformational landscape and ligand-dependent clustering of the human type 2 IP 3 receptor.
Journal, issue, pagesNat Commun, Year 2026
Publish dateOct 7, 2025 (structure data deposition date)
AuthorsLiu, C. / Lan, Y.J. / Kushner, M.G. / Tang, Q. / Karakas, E.
External linksNat Commun / PubMed:42315508
MethodsEM (single particle)
Resolution2.95 - 4.06 Å
Structure data

PDB-9ykk:
Human type 2 IP3 receptor in apo state
Method: ELECTRON MICROSCOPY / Resolution: 2.95 Å

PDB-9yky:
IP3/ATP-bound human type 2 IP3 receptor in the resting state
Method: ELECTRON MICROSCOPY / Resolution: 3.31 Å

PDB-9yli:
IP3/ATP-bound human type 2 IP3 receptor in the preactivated state
Method: ELECTRON MICROSCOPY / Resolution: 3.33 Å

PDB-9ymz:
Human type 2 IP3 receptor in the inactive-like state (IP3/ATP)
Method: ELECTRON MICROSCOPY / Resolution: 3.14 Å

PDB-9ynk:
Human type 2 IP3 receptor in the inactive-like state (IP3/ATP/Ca2+)
Method: ELECTRON MICROSCOPY / Resolution: 3.42 Å

PDB-9yno:
Human type 2 IP3 receptor dimer (IP3/ATP/Ca2+)
Method: ELECTRON MICROSCOPY / Resolution: 4.06 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-I3P:
D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

ChemComp-HOH:
WATER

ChemComp-CA:
Unknown entry

Source
  • homo sapiens (human)
KeywordsTRANSPORT PROTEIN / Inositol 1 / 4 / 5-triphosphate / IP3 / receptor / calcium channel / type-2 / IP3R / IP3R-2 / ITPR2

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