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| Title | When VPS34 complexes double down: Two RAB5s for VPS34-CII, two RAB1s for NRBF2-dimerized VPS34-CI |
|---|---|
| Journal, issue, pages | To Be Published |
| Publish date | Jul 9, 2025 (structure data deposition date) |
Authors | Spokaite S / Ohashi Y / Dessus AN / Bourguet M / Williams RL |
External links | Search PubMed |
| Methods | EM (single particle) |
| Resolution | 3.33 - 3.8 Å |
| Structure data | ![]() EMDB-54307: VPS34-CI bound to NRBF2 and RAB1A, focused refinement on the kinase arm ![]() EMDB-54308: VPS34-CI bound to NRBF2 and RAB1A, focused refinement on the adaptor arm ![]() EMDB-54309: VPS34-CI bound to NRBF2 and RAB1A, focused refinement on the interface between RAB1A and VPS34 ![]() EMDB-54310: VPS34-CI bound to NRBF2 and RAB1A, consensus refinement ![]() EMDB-54311: VPS34-CI bound to NRBF2 and RAB1A; composite unsharpened map ![]() EMDB-54323: VPS34-CI bound to NRBF2 MIT domain (residues 1-79), focused refinement on the VPS34 kinase domain and VPS15 pseudokinase domain ![]() EMDB-54324: VPS34-CI bound to NRBF2 MIT domain (residues 1-79), focused refinement on the VPS15 WD40 domain, BECLIN1 BARA domain, and ATG14L CTD ![]() EMDB-54325: VPS34-CI bound to NRBF2 MIT domain (residues 1-79, focused refinement on the VPS15 helical solenoid, and ATG14L/BECLIN1 CC1 and N-terminal domains ![]() EMDB-54326: VPS34-CI bound to NRBF2 MIT domain (residues 1-79), consensus refinement EMDB-54357: VPS34-CI bound to NRBF2 and RAB1A, primary composite map processed with CryoTEN EMDB-54360: VPS34-CI bound to NRBF2 MIT domain (residues 1-79), unsharpened composite EM map |
| Chemicals | ![]() ChemComp-GDP: ![]() ChemComp-MG: ![]() ChemComp-MYR: ![]() ChemComp-ZN: ![]() ChemComp-GTP: |
| Source |
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Keywords | SIGNALING PROTEIN / Lipid kinase / GTPase / kinase / autophagy |
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