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TitleStructural bases for integrase-RNA binding and retention of viral RNA within HIV-1 capsid cores
Journal, issue, pagesTo Be Published
Publish dateJun 19, 2025 (structure data deposition date)
AuthorsSinger M / Li Z / Rey JS / Hope J / Cook NJ / Puch E / Smith J / Zhou Z / Maslen S / Masino L ...Singer M / Li Z / Rey JS / Hope J / Cook NJ / Puch E / Smith J / Zhou Z / Maslen S / Masino L / Nans A / Skehel M / Taylor IA / Zhang P / Perilla JR / Engelman AN / Cherepanov P
External linksSearch PubMed
MethodsEM (single particle) / EM (subtomogram averaging)
Resolution4.63 - 12.56 Å
Structure data

EMDB-54070: CryoEM reconstruction of integrase filament at the lumen of native HIV-1 cores (box size 47.3 nm)
Method: EM (single particle) / Resolution: 4.85 Å

54071

9rmx

EMDB-54071, PDB-9rmx:
CryoEM reconstruction of integrase filament at the lumen of native HIV-1 cores (box size 34.2 nm)
Method: EM (single particle) / Resolution: 4.63 Å

EMDB-55409: HIV-1 integrase filament at the luminal side of capsid lattice by subtomogram averaging.
Method: EM (subtomogram averaging) / Resolution: 12.56 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-IHP:
INOSITOL HEXAKISPHOSPHATE

Source
  • human immunodeficiency virus 1
KeywordsVIRAL PROTEIN / integrase / capsid / HIV-1 / RNA

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