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Structure paper

TitlePsychedelics elicit their effects by 5-HT receptor-mediated G signalling.
Journal, issue, pagesNature, Year 2026
Publish dateJan 28, 2026
AuthorsZheng Xu / Hongshuang Wang / Jingjing Yu / Yue Deng / Xiaowen Tian / Rongjun Ni / Fan Xia / Lingyi Yang / Chanjuan Xu / Liting Zhang / Renxuan Luo / Peipei Chen / Xiaoyu Zhang / Yuxuan Liu / Jingyu Hou / Miyuan Zhang / Shasha Chen / Lantian Su / Hui Sun / Yixiao He / Dandan Chen / Xiaoting Chen / Zhuang Miao / Jie Xie / Xinlei Liu / Jie Zhao / Bowen Ke / Xiaohe Tian / Linan Zeng / Lingli Zhang / Xiangdong Tang / Shengyong Yang / Jianfeng Liu / Xiaohui Wang / Wei Yan / Zhenhua Shao /
PubMed AbstractPsychedelics are undergoing a renaissance as potential therapy for psychiatric disorders, with more than 200 clinical trials being studied across several countries. However, the precise mechanisms by ...Psychedelics are undergoing a renaissance as potential therapy for psychiatric disorders, with more than 200 clinical trials being studied across several countries. However, the precise mechanisms by which these drugs bring about benefits and the potential clinical risks are not yet fully understood. The serotonin 2A receptor (5-HTR) was reported to be a G-coupled receptor and the primary interoceptive target of psychedelics. Here we compared psychedelics and their non-hallucinogenic analogues (nHAs) using in vitro and in vivo approaches, finding that 5-HTR-mediated non-canonical G signalling is essential for hallucinogenic effect. We further presented five cryo-electron microscopy structures of 5-HTR-G/G in complex with psychedelics or nHAs. Structural analysis and pharmacological investigation revealed that a special contact between nHAs with 5-HTR mediated the signalling bias. Building on this insight, we identified a 2,5-dimethoxy-4-iodoamphetamine derivative, DOI-NBOMe, which exhibits potent and selective G-biased activity, and demonstrates promising therapeutic effects in mouse models without hallucinogenic effect. Our finding uncovers the functional mechanisms underlying the G signalling mediated by 5-HTR and provides valuable insights for designing psychedelic-based drugs with minimized risk from hallucinogenic effects.
External linksNature / PubMed:41606342
MethodsEM (single particle)
Resolution2.62 - 3.27 Å
Structure data

63192

9ll7

EMDB-63192, PDB-9ll7:
DOI-bound Serotonin 2A (5-HT2A) receptor-Gi complex
Method: EM (single particle) / Resolution: 2.84 Å

63193

9ll8

EMDB-63193, PDB-9ll8:
Psilocin-bound Serotonin 2A (5-HT2A) receptor-Gi complex
Method: EM (single particle) / Resolution: 2.62 Å

63194

9ll9

EMDB-63194, PDB-9ll9:
DOI-bound Serotonin 2A (5-HT2A) receptor-Gq complex
Method: EM (single particle) / Resolution: 2.76 Å

63195

9lla

EMDB-63195, PDB-9lla:
Ariadne-bound Serotonin 2A (5-HT2A) receptor-Gq complex
Method: EM (single particle) / Resolution: 3.27 Å

63196

9llb

EMDB-63196, PDB-9llb:
DOI-NBOMe-bound Serotonin 2A (5-HT2A) receptor-Gq complex
Method: EM (single particle) / Resolution: 2.98 Å

Chemicals

ChemComp-CLR:
CHOLESTEROL

PDB-1ek5:
STRUCTURE OF HUMAN UDP-GALACTOSE 4-EPIMERASE IN COMPLEX WITH NAD+

ChemComp-HOH:
WATER

ChemComp-91Q:
3-[2-(dimethylamino)ethyl]-1~{H}-indol-4-ol / alkaloid*YM

PDB-1ek8:
CRYSTAL STRUCTURE OF THE RIBOSOME RECYCLING FACTOR (RRF) FROM ESCHERICHIA COLI

PDB-1ela:
Analogous inhibitors of elastase do not always bind analogously

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsMEMBRANE PROTEIN / complex / agonist

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