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Structure paper

Titlea5b3 GABAAR bound to GABA and Mb25 in a desensitized state in saposin nanodiscs after long GABA treatment
Journal, issue, pagesTo Be Published
Publish dateDec 11, 2024 (structure data deposition date)
AuthorsCowgill J / Fan C / Howard RJ / Lindahl E
External linksSearch PubMed
MethodsEM (single particle)
Resolution3.1 Å
Structure data

52314

9hns

EMDB-52314, PDB-9hns:
a5b3 GABAAR bound to GABA and Mb25 in a desensitized state in saposin nanodiscs after long GABA treatment
Method: EM (single particle) / Resolution: 3.1 Å

Chemicals

ChemComp-ABU:
GAMMA-AMINO-BUTANOIC ACID / neurotransmitter, inhibitor*YM

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
  • escherichia coli (E. coli)
  • aequorea victoria (jellyfish)
KeywordsMEMBRANE PROTEIN / GABA receptor / pentameric ligand gated ion channel / cys-loop receptor

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