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TitleConcerted deletions eliminate a neutralizing supersite in SARS-CoV-2 BA.2.87.1 spike.
Journal, issue, pagesStructure, Vol. 32, Issue 10, Page 1594-11602.e6, Year 2024
Publish dateOct 3, 2024
AuthorsHelen M E Duyvesteyn / Aiste Dijokaite-Guraliuc / Chang Liu / Piyada Supasa / Barbara Kronsteiner / Katie Jeffery / Lizzie Stafford / Paul Klenerman / Susanna J Dunachie / / Juthathip Mongkolsapaya / Elizabeth E Fry / Jingshan Ren / David I Stuart / Gavin R Screaton /
PubMed AbstractBA.2.87.1 represents a major shift in the BA.2 lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is unusual in having two lengthy deletions of polypeptide in the spike (S) ...BA.2.87.1 represents a major shift in the BA.2 lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is unusual in having two lengthy deletions of polypeptide in the spike (S) protein, one of which removes a beta-strand. Here we investigate its neutralization by a variety of sera from infected and vaccinated individuals and determine its spike (S) ectodomain structure. The BA.2.87.1 receptor binding domain (RBD) is structurally conserved and the RBDs are tightly packed in an "all-down" conformation with a small rotation relative to the trimer axis as compared to the closest previously observed conformation. The N-terminal domain (NTD) maintains a remarkably similar structure overall; however, the rearrangements resulting from the deletions essentially destroy the so-called supersite epitope and eliminate one glycan site, while a mutation creates an additional glycan site, effectively shielding another NTD epitope. BA.2.87.1 is relatively easily neutralized but acquisition of additional mutations in the RBD could increase antibody escape allowing it to become a dominant sub-lineage.
External linksStructure / PubMed:39173622
MethodsEM (single particle)
Resolution2.8 Å
Structure data

50263

9f9y

EMDB-50263, PDB-9f9y:
SARS-CoV-2 BA-2.87.1 Spike ectodomain
Method: EM (single particle) / Resolution: 2.8 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • severe acute respiratory syndrome coronavirus 2
  • enterobacteria phage t4 (virus)
KeywordsVIRAL PROTEIN / immune system / SARS-CoV-2 / RBD / Spike / glycoprotein / BA.2.87.1 / receptor / coronavirus-2 / N-terminal domain / Supersite

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