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TitleInteractions of Phenylalanine Derivatives with Human Tyrosinase: Lessons from Experimental and Theoretical tudies.
Journal, issue, pagesChembiochem, Vol. 25, Page e202400235-e202400235, Year 2024
Publish dateApr 9, 2024 (structure data deposition date)
AuthorsFaure, C. / Min Ng, Y. / Belle, C. / Soler-Lopez, M. / Khettabi, L. / Saidi, M. / Berthet, N. / Maresca, M. / Philouze, C. / Rachidi, W. ...Faure, C. / Min Ng, Y. / Belle, C. / Soler-Lopez, M. / Khettabi, L. / Saidi, M. / Berthet, N. / Maresca, M. / Philouze, C. / Rachidi, W. / Reglier, M. / du Moulinet d'Hardemare, A. / Jamet, H.
External linksChembiochem / PubMed:38642076
MethodsX-ray diffraction
Resolution2.2 - 2.61 Å
Structure data

PDB-9ey5:
Crystal structure of human tyrosinase-related protein 1 (TYRP1) in complex with (S)-2,4-dihydroxyphenylalanine
Method: X-RAY DIFFRACTION / Resolution: 2.61 Å

PDB-9ey6:
Crystal structure of human tyrosinase-related protein 1 (TYRP1)
Method: X-RAY DIFFRACTION / Resolution: 2.228 Å

PDB-9ey7:
Crystal structure of human tyrosinase-related protein 1 (TYRP1) in complex with (R)-2,4-dihydroxyphenylalanine
Method: X-RAY DIFFRACTION / Resolution: 2.61 Å

PDB-9ey8:
Crystal structure of human tyrosinase-related protein 1 (TYRP1) in complex with (s)-amino-L-tyrosine
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-OTY:
2-hydroxy-L-tyrosine

ChemComp-GOL:
GLYCEROL

ChemComp-ZN:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-TY2:
3-AMINO-L-TYROSINE

Source
  • homo sapiens (human)
KeywordsMETAL BINDING PROTEIN / melanogenesis / human tyrosinase / tyrosinase inhibitor

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