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Structure paper

TitlePromiscuous G-protein activation by the calcium-sensing receptor
Journal, issue, pagesNature, Year 2024
Publish dateFeb 24, 2024 (structure data deposition date)
AuthorsZuo H / Park J / Frangaj A / Ye J / Lu G / Manning JJ / Asher WB / Lu Z / Hu G / Wang L ...Zuo H / Park J / Frangaj A / Ye J / Lu G / Manning JJ / Asher WB / Lu Z / Hu G / Wang L / Mendez J / Eng E / Zhang Z / Lin X / Grasucci R / Hendrickson WA / Clarke OB / Javitch JA / Conigrave AD / Fan QR
External linksNature / Search PubMed
MethodsEM (single particle)
Resolution2.9 - 4.0 Å
Structure data

43811

9asb

EMDB-43811, PDB-9asb:
Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in nanodiscs
Method: EM (single particle) / Resolution: 3.4 Å

EMDB-43836: Consensus map of human CaSR-miniGisq complex in nanodiscs
Method: EM (single particle) / Resolution: 3.4 Å

EMDB-43837: Local refinement map of CaSR extracellular domain in nanodisc-reconstituted human CaSR-miniGisq complex
Method: EM (single particle) / Resolution: 3.0 Å

EMDB-43840: Local refinement map of CaSR transmembrane domain in nanodisc-reconstituted human CaSR-miniGisq complex
Method: EM (single particle) / Resolution: 3.3 Å

EMDB-43841: Local refinement map of G protein in nanodisc-reconstituted human CaSR-miniGisq complex
Method: EM (single particle) / Resolution: 3.7 Å

EMDB-43897: Consensus map of human CaSR-miniGis complex in nanodiscs
Method: EM (single particle) / Resolution: 3.6 Å

EMDB-43898: Local refinement map of CaSR extracellular domain in nanodisc-reconstituted human CaSR-miniGis complex
Method: EM (single particle) / Resolution: 2.9 Å

EMDB-43899: Local refinement map of CaSR transmembrane domain in nanodisc-reconstituted human CaSR-miniGis complex
Method: EM (single particle) / Resolution: 3.4 Å

EMDB-43900: Local refinement map of G protein in nanodisc-reconstituted human CaSR-miniGis complex
Method: EM (single particle) / Resolution: 4.0 Å

43901

9avg

EMDB-43901, PDB-9avg:
Structure of human calcium-sensing receptor in complex with chimeric Gs (miniGis) protein in nanodiscs
Method: EM (single particle) / Resolution: 3.6 Å

EMDB-43904: Consensus map of human CaSR-Gi3 complex in nanodiscs
Method: EM (single particle) / Resolution: 3.8 Å

EMDB-43905: Local refinement map of CaSR extracellular domain in nanodisc-reconstituted human CaSR-Gi3 complex
Method: EM (single particle) / Resolution: 3.1 Å

EMDB-43906: Local refinement map of CaSR transmembrane domain in nanodisc-reconstituted human CaSR-Gi3 complex
Method: EM (single particle) / Resolution: 3.5 Å

EMDB-43907: Local refinement map of G protein in nanodisc-reconstituted human CaSR-Gi3 complex
Method: EM (single particle) / Resolution: 3.3 Å

43908

9avl

EMDB-43908, PDB-9avl:
Structure of human calcium-sensing receptor in complex with Gi3 protein in nanodiscs
Method: EM (single particle) / Resolution: 3.8 Å

EMDB-43961: Consensus map of human CaSR-miniGisq complex in detergent
Method: EM (single particle) / Resolution: 3.5 Å

EMDB-43962: Local refinement map of CaSR extracellular domain (ECD) in detergent-solubilized human CaSR-miniGisq complex
Method: EM (single particle) / Resolution: 3.1 Å

EMDB-43963: Local refinement map of CaSR transmembrane domain (TMD) in detergent-solubilized human CaSR-miniGisq complex
Method: EM (single particle) / Resolution: 3.3 Å

EMDB-43964: Local refinement map of G protein in detergent-solubilized human CaSR-miniGisq complex
Method: EM (single particle) / Resolution: 3.1 Å

43966

9axf

EMDB-43966, PDB-9axf:
Structure of human calcium-sensing receptor in complex with chimeric Gq (miniGisq) protein in detergent
Method: EM (single particle) / Resolution: 3.5 Å

EMDB-43986: Consensus map of human CaSR-miniGi1 complex in detergent
Method: EM (single particle) / Resolution: 3.6 Å

EMDB-43987: Local refinement map of CaSR extracellular domain (ECD) in detergent-solubilized human CaSR-miniGi1 complex
Method: EM (single particle) / Resolution: 3.1 Å

EMDB-43988: Local refinement map of CaSR transmembrane domain (TMD) in detergent-solubilized human CaSR-miniGi1 complex
Method: EM (single particle) / Resolution: 3.6 Å

EMDB-43989: Local refinement map of G protein in detergent-solubilized human CaSR-miniGi1 complex
Method: EM (single particle) / Resolution: 3.2 Å

43990

9ayf

EMDB-43990, PDB-9ayf:
Structure of human calcium-sensing receptor in complex with Gi1 (miniGi1) protein in detergent
Method: EM (single particle) / Resolution: 3.6 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose / N-Acetylglucosamine

ChemComp-TCR:
CYCLOMETHYLTRYPTOPHAN

ChemComp-PO4:
PHOSPHATE ION / Phosphate

ChemComp-CA:
Unknown entry

ChemComp-9IG:
3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine

ChemComp-Y01:
CHOLESTEROL HEMISUCCINATE

PDB-1af7:
CHER FROM SALMONELLA TYPHIMURIUM

ChemComp-AV0:
Lauryl Maltose Neopentyl Glycol

ChemComp-CLR:
CHOLESTEROL / Cholesterol

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
  • lama glama (llama)
KeywordsMEMBRANE PROTEIN / Calcium-sensing receptor / G-protein-coupled receptor / G protein / signal transduction

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