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TitleImplication of Stm1 in the protection of eIF5A, eEF2 and tRNA through dormant ribosomes.
Journal, issue, pagesFront Mol Biosci, Vol. 11, Page 1395220, Year 2024
Publish dateApr 18, 2024
AuthorsMengtan Du / Xin Li / Wanlin Dong / Fuxing Zeng /
PubMed Abstract Dormant ribosomes are typically associated with preservation factors to protect themselves from degradation under stress conditions. Stm1/SERBP1 is one such protein that anchors the 40S and 60S ... Dormant ribosomes are typically associated with preservation factors to protect themselves from degradation under stress conditions. Stm1/SERBP1 is one such protein that anchors the 40S and 60S subunits together. Several proteins and tRNAs bind to this complex as well, yet the molecular mechanisms remain unclear. Here, we reported the cryo-EM structures of five newly identified Stm1/SERBP1-bound ribosomes. These structures highlighted that eIF5A, eEF2, and tRNA might bind to dormant ribosomes under stress to avoid their own degradation, thus facilitating protein synthesis upon the restoration of growth conditions. In addition, Ribo-seq data analysis reflected the upregulation of nutrient, metabolism, and external-stimulus-related pathways in the strain, suggesting possible regulatory roles of Stm1. The knowledge generated from the present work will facilitate in better understanding the molecular mechanism of dormant ribosomes.
External linksFront Mol Biosci / PubMed:38698775 / PubMed Central
MethodsEM (single particle)
Resolution3.2 - 3.59 Å
Structure data

37991

8y0w

EMDB-37991: Dormant Ribosome with eIF5A,eEF2 and SERBP1
PDB-8y0w: dormant ribosome with eIF5A, eEF2 and SERBP1
Method: EM (single particle) / Resolution: 3.4 Å

37992

8y0x

EMDB-37992: Dormant Ribosome with eEF2 and SERBP1
PDB-8y0x: Dormant ribosome with SERBP1
Method: EM (single particle) / Resolution: 3.3 Å

EMDB-37993: dormant ribosome with STM1
Method: EM (single particle) / Resolution: 3.2 Å

EMDB-37994: dormant ribosome with STM1
Method: EM (single particle) / Resolution: 3.59 Å

37995

8y0u

EMDB-37995, PDB-8y0u:
dormant ribosome with STM1
Method: EM (single particle) / Resolution: 3.59 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-ZN:
Unknown entry

Source
  • homo sapiens (human)
  • saccharomyces cerevisiae (brewer's yeast)
KeywordsRIBOSOME / STM1 / dormant ribosome / SERBP1

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