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Structure paper

TitleStructural and biophysical comparisons of the pomalidomide- and CC-220-induced interactions of SALL4 with cereblon.
Journal, issue, pagesSci Rep, Vol. 13, Page 22088-22088, Year 2023
Publish dateAug 30, 2023 (structure data deposition date)
AuthorsMa, X. / Leon, B. / Ornelas, E. / Dovala, D. / Tandeske, L. / Luu, C. / Pardee, G. / Widger, S. / Solomon, J.M. / Beckwith, R.E.J. ...Ma, X. / Leon, B. / Ornelas, E. / Dovala, D. / Tandeske, L. / Luu, C. / Pardee, G. / Widger, S. / Solomon, J.M. / Beckwith, R.E.J. / Moser, H. / Clifton, M.C. / Wartchow, C.A.
External linksSci Rep / PubMed:38086859
MethodsX-ray diffraction
Resolution2.9 - 3.1 Å
Structure data

PDB-8u15:
The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-short bound to CC-220
Method: X-RAY DIFFRACTION / Resolution: 2.95 Å

PDB-8u16:
The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-short bound to Pomalidomide
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-8u17:
The ternary complex structure of DDB1-CRBN-SALL4(ZF1,2)-long bound to Pomalidomide
Method: X-RAY DIFFRACTION / Resolution: 3.1 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-8W7:
(3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-Y70:
S-Pomalidomide

ChemComp-EDO:
1,2-ETHANEDIOL

Source
  • homo sapiens (human)
KeywordsLIGASE / Complex / glue

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