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Title | Epistasis arises from shifting the rate-limiting step during enzyme evolution of a beta-lactamase. |
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Journal, issue, pages | Nat Catal, Vol. 7, Page 499-509, Year 2024 |
Publish date | Jun 13, 2023 (structure data deposition date) |
![]() | Frohlich, C. / Bunzel, H.A. / Buda, K. / Mulholland, A.J. / van der Kamp, M.W. / Johnsen, P.J. / Leiros, H.S. / Tokuriki, N. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 1.17 - 2.66 Å |
Structure data | ![]() PDB-8pea: ![]() PDB-8peb: ![]() PDB-8pec: |
Chemicals | ![]() ChemComp-CL: ![]() ChemComp-HOH: ![]() ChemComp-SO4: ![]() ChemComp-PEG: ![]() ChemComp-MLI: ![]() ChemComp-CTJ: |
Source |
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![]() | HYDROLASE / Protein evolution. Antibiotic resistance. OXA-48. / Protein evolution. Antibiotic resistance. OXA-48. HYDROLASE. Serine-Beta-lactamase. |