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Title | Design and Synthesis of Functionally Active 5-Amino-6-Aryl Pyrrolopyrimidine Inhibitors of Hematopoietic Progenitor Kinase 1. |
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Journal, issue, pages | J. Med. Chem., Vol. 66, Page 4888-4909, Year 2023 |
Publish date | Dec 13, 2022 (structure data deposition date) |
![]() | Gallego, R.A. / Bernier, L. / Chen, H. / Cho-Schultz, S. / Chung, L. / Collins, M. / Del Bel, M. / Elleraas, J. / Costa Jones, C. / Cronin, C.N. ...Gallego, R.A. / Bernier, L. / Chen, H. / Cho-Schultz, S. / Chung, L. / Collins, M. / Del Bel, M. / Elleraas, J. / Costa Jones, C. / Cronin, C.N. / Edwards, M. / Fang, X. / Fisher, T. / He, M. / Hoffman, J. / Huo, R. / Jalaie, M. / Johnson, E. / Johnson, T.W. / Kania, R.S. / Kraus, M. / Lafontaine, J. / Le, P. / Liu, T. / Maestre, M. / Matthews, J. / McTigue, M. / Miller, N. / Mu, Q. / Qin, X. / Ren, S. / Richardson, P. / Rohner, A. / Sach, N. / Shao, L. / Smith, G. / Su, R. / Sun, B. / Timofeevski, S. / Tran, P. / Wang, S. / Wang, W. / Zhou, R. / Zhu, J. / Nair, S.K. |
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Methods | X-ray diffraction |
Resolution | 1.827 - 2.3 Å |
Structure data | ![]() PDB-8fh4: ![]() PDB-8fjz: ![]() PDB-8fko: ![]() PDB-8fp1: ![]() PDB-8fp3: |
Chemicals | ![]() ChemComp-XXF: ![]() ChemComp-SO4: ![]() ChemComp-HOH: ![]() ChemComp-Y3I: ![]() ChemComp-Y3O: |
Source |
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![]() | TRANSFERASE / inhibitor / hematopoietic / kinase / TRANSFERASE/INHIBITOR / TRANSFERASE-INHIBITOR complex / HPK1 / Structure based drug design / cancer |