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TitleZika-specific neutralizing antibodies targeting inter-dimer envelope epitopes.
Journal, issue, pagesCell Rep, Vol. 42, Page 112942-112942, Year 2023
Publish dateSep 6, 2022 (structure data deposition date)
AuthorsSankhala, R.S. / Dussupt, V. / Donofrio, G. / Gromowski, G.D. / De La Barrera, R.A. / Larocca, R.A. / Mendez-Rivera, L. / Lee, A. / Choe, M. / Zaky, W. ...Sankhala, R.S. / Dussupt, V. / Donofrio, G. / Gromowski, G.D. / De La Barrera, R.A. / Larocca, R.A. / Mendez-Rivera, L. / Lee, A. / Choe, M. / Zaky, W. / Mantus, G. / Jensen, J.L. / Chen, W.H. / Gohain, N. / Bai, H. / McCracken, M.K. / Mason, R.D. / Leggat, D. / Slike, B.M. / Tran, U. / Jian, N. / Abbink, P. / Peterson, R. / Mendes, E.A. / Freitas de Oliveira Franca, R. / Calvet, G.A. / Bispo de Filippis, A.M. / McDermott, A. / Roederer, M. / Hernandez, M. / Albertus, A. / Davidson, E. / Doranz, B.J. / Rolland, M. / Robb, M.L. / Lynch, R.M. / Barouch, D.H. / Jarman, R.G. / Thomas, S.J. / Modjarrad, K. / Michael, N.L. / Krebs, S.J. / Joyce, M.G.
External linksCell Rep / PubMed:37561630
MethodsX-ray diffraction
Resolution1.672 - 3.583 Å
Structure data

PDB-8ee5:
Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ119-D in complex with ZIKV E glycoprotein
Method: X-RAY DIFFRACTION / Resolution: 3.583 Å

PDB-8ee8:
Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ100-C in complex with ZIKV E glycoprotein
Method: X-RAY DIFFRACTION / Resolution: 2.803 Å

PDB-8eed:
Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ107-B in complex with ZIKV E glycoprotein
Method: X-RAY DIFFRACTION / Resolution: 3.487 Å

PDB-8eee:
Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ104-d in complex with ZIKV E glycoprotein
Method: X-RAY DIFFRACTION / Resolution: 2.819 Å

PDB-8eez:
Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ100-C
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-8ef0:
Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ104-D
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

PDB-8ef1:
Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ103-A
Method: X-RAY DIFFRACTION / Resolution: 1.87 Å

PDB-8ef2:
Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ107-B
Method: X-RAY DIFFRACTION / Resolution: 2.102 Å

PDB-8ef3:
Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ119-D
Method: X-RAY DIFFRACTION / Resolution: 1.672 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-ZN:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

Source
  • zika virus zikv/h. sapiens/frenchpolynesia/10087pf/2013
  • macaca mulatta (Rhesus monkey)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / ZIKV / ZIKV-specific / cross-protomer epitopes / VIRAL PROTEIN / VIRAL PROTEIN-IMMUNE SYSTEM complex / IMMUNE SYSTEM

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