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TitleCross-species recognition and molecular basis of SARS-CoV-2 and SARS-CoV binding to ACE2s of marine animals.
Journal, issue, pagesNatl Sci Rev, Vol. 9, Issue 9, Page nwac122, Year 2022
Publish dateJun 23, 2022
AuthorsShihua Li / Ruirui Yang / Di Zhang / Pu Han / Zepeng Xu / Qian Chen / Runchu Zhao / Xin Zhao / Xiao Qu / Anqi Zheng / Liang Wang / Linjie Li / Yu Hu / Rong Zhang / Chao Su / Sheng Niu / Yanfang Zhang / Jianxun Qi / Kefang Liu / Qihui Wang / George F Gao /
PubMed AbstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has an extremely broad host range that includes hippopotami, which are phylogenetically closely related to whales. The cellular ACE2 ...Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has an extremely broad host range that includes hippopotami, which are phylogenetically closely related to whales. The cellular ACE2 receptor is one of the key determinants of the host range. Here, we found that ACE2s from several marine mammals and hippopotami could efficiently bind to the receptor-binding domain (RBD) of both SARS-CoV and SARS-CoV-2 and facilitate the transduction of SARS-CoV and SARS-CoV-2 pseudoviruses into ACE2-expressing cells. We further resolved the cryo-electron microscopy complex structures of the minke whale ACE2 and sea lion ACE2, respectively, bound to the RBDs, revealing that they have similar binding modes to human ACE2 when it comes to the SARS-CoV-2 RBD and SARS-CoV RBD. Our results indicate that marine mammals could potentially be new victims or virus carriers of SARS-CoV-2, which deserves further careful investigation and study. It will provide an early warning for the prospective monitoring of marine mammals.
External linksNatl Sci Rev / PubMed:36187898 / PubMed Central
MethodsEM (single particle)
Resolution2.87 - 3.03 Å
Structure data

32755

7wse

EMDB-32755, PDB-7wse:
Cryo-EM structure of SARS-CoV-2 spike receptor-binding domain complexed with its receptor minke whale ACE2
Method: EM (single particle) / Resolution: 2.93 Å

32756

7wsf

EMDB-32756, PDB-7wsf:
Cryo-EM structure of SARS-CoV spike receptor-binding domain in complex with minke whale ACE2
Method: EM (single particle) / Resolution: 2.87 Å

32757

7wsg

EMDB-32757, PDB-7wsg:
Cryo-EM structure of SARS-CoV spike receptor-binding domain in complex with sea lion ACE2
Method: EM (single particle) / Resolution: 3.03 Å

32758

7wsh

EMDB-32758, PDB-7wsh:
Cryo-EM structure of SARS-CoV-2 spike receptor-binding domain in complex with sea lion ACE2
Method: EM (single particle) / Resolution: 2.89 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose / N-Acetylglucosamine

Source
  • mammalia (mammals)
  • severe acute respiratory syndrome coronavirus 2
  • severe acute respiratory syndrome coronavirus
KeywordsVIRAL PROTEIN / Complex

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