| タイトル | CaMKII binds both substrates and activators at the active site. |
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| ジャーナル・号・ページ | Cell Rep, Vol. 40, Page 111064-111064, Year 2022 |
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| 掲載日 | 2020年5月26日 (構造データの登録日) |
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著者 | Ozden, C. / Sloutsky, R. / Mitsugi, T. / Santos, N. / Agnello, E. / Gaubitz, C. / Foster, J. / Lapinskas, E. / Esposito, E.A. / Saneyoshi, T. ...Ozden, C. / Sloutsky, R. / Mitsugi, T. / Santos, N. / Agnello, E. / Gaubitz, C. / Foster, J. / Lapinskas, E. / Esposito, E.A. / Saneyoshi, T. / Kelch, B.A. / Garman, S.C. / Hayashi, Y. / Stratton, M.M. |
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リンク | Cell Rep / PubMed:35830796 |
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| 手法 | X線回折 |
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| 解像度 | 1.85 - 3.11 Å |
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| 構造データ | PDB-6x5g: Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and LRRC7 inhibitory domain 手法: X-RAY DIFFRACTION / 解像度: 1.85 Å PDB-6x5q: Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluA1 手法: X-RAY DIFFRACTION / 解像度: 2.14 Å PDB-7kl0: Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D) 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-7kl1: Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D) 手法: X-RAY DIFFRACTION / 解像度: 2.4 Å PDB-7uiq: Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and Tiam1 手法: X-RAY DIFFRACTION / 解像度: 3.11 Å PDB-7uir: Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and Tiam1 in complex with ATP 手法: X-RAY DIFFRACTION / 解像度: 3.1 Å PDB-7uis: Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D) 手法: X-RAY DIFFRACTION / 解像度: 2.58 Å PDB-7ujp: Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B 手法: X-RAY DIFFRACTION / 解像度: 2.56 Å PDB-7ujq: Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B 手法: X-RAY DIFFRACTION / 解像度: 2.25 Å PDB-7ujr: Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B 手法: X-RAY DIFFRACTION / 解像度: 1.95 Å PDB-7ujs: Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B in complex with ADP 手法: X-RAY DIFFRACTION / 解像度: 2.75 Å PDB-7ujt: Cocrystal structure of human CaMKII-alpha (CAMK2A)kinase domain and GluN2B(S1303D) in complex with ATP 手法: X-RAY DIFFRACTION / 解像度: 2.1 Å |
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| 化合物 | ChemComp-UZD: methyl 6-O-(heptylcarbamoyl)-beta-L-altropyranoside
ChemComp-ATP: ADENOSINE-5'-TRIPHOSPHATE / ATP, エネルギー貯蔵分子*YM
ChemComp-EPE: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH緩衝剤*YM
ChemComp-ADP: ADENOSINE-5'-DIPHOSPHATE / ADP, エネルギー貯蔵分子*YM
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| 由来 | homo sapiens (ヒト) mus musculus (ハツカネズミ)
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キーワード | TRANSFERASE / CaMKII / Kinase / Human / CAMK2A |
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