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Structure paper

TitleThe structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3.
Journal, issue, pagesNucleic Acids Res., Vol. 50, Page 13083-13099, Year 2022
Publish dateAug 13, 2021 (structure data deposition date)
AuthorsHall, D. / Giaimo, B.D. / Park, S.S. / Hemmer, W. / Friedrich, T. / Ferrante, F. / Bartkuhn, M. / Yuan, Z. / Oswald, F. / Borggrefe, T. ...Hall, D. / Giaimo, B.D. / Park, S.S. / Hemmer, W. / Friedrich, T. / Ferrante, F. / Bartkuhn, M. / Yuan, Z. / Oswald, F. / Borggrefe, T. / Rual, J.F. / Kovall, R.A.
External linksNucleic Acids Res. / PubMed:36477367
MethodsX-ray diffraction
Resolution2.05 - 2.06 Å
Structure data

PDB-7rte:
X-ray structure of wild type RBPJ-L3MBTL3-DNA complex
Method: X-RAY DIFFRACTION / Resolution: 2.06 Å

PDB-7rti:
X-ray structure of RBPJ-L3MBTL3(dT62)-DNA complex
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-XYZ:
beta-D-xylofuranose

ChemComp-HOH:
WATER

Source
  • mus musculus (house mouse)
  • synthetic dna (others)
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN/DNA / Notch signaling / transcription / RBPJ / CSL / L3MBTL3 / DNA BINDING PROTEIN-DNA complex

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