Entry Database : PDB / ID : 7rti Structure visualization Downloads & linksTitle X-ray structure of RBPJ-L3MBTL3(dT62)-DNA complex ComponentsDNA (5'-D(*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*GP*GP*T)-3')DNA (5'-D(*TP*TP*AP*CP*CP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3')Lethal(3)malignant brain tumor-like protein 3 Recombining binding protein suppressor of hairless DetailsKeywords DNA BINDING PROTEIN/DNA / Notch signaling / transcription / RBPJ / CSL / L3MBTL3 / DNA BINDING PROTEIN-DNA complexFunction / homology Function and homology informationFunction Domain/homology Component
determination of heart left/right asymmetry / regulation of generation of precursor metabolites and energy / blood vessel endothelial cell fate specification / positive regulation of ERBB signaling pathway / club cell differentiation / arterial endothelial cell fate commitment / blood vessel lumenization / regulation of timing of cell differentiation / regulation of reproductive process / methylation-dependent protein binding ... determination of heart left/right asymmetry / regulation of generation of precursor metabolites and energy / blood vessel endothelial cell fate specification / positive regulation of ERBB signaling pathway / club cell differentiation / arterial endothelial cell fate commitment / blood vessel lumenization / regulation of timing of cell differentiation / regulation of reproductive process / methylation-dependent protein binding / positive regulation of ephrin receptor signaling pathway / secondary heart field specification / pulmonary valve development / positive regulation of cell proliferation involved in heart morphogenesis / dorsal aorta morphogenesis / sebaceous gland development / endocardium morphogenesis / regulation of cell adhesion involved in heart morphogenesis / MAML1-RBP-Jkappa- ICN1 complex / aortic valve development / auditory receptor cell fate commitment / NOTCH1 Intracellular Domain Regulates Transcription / RUNX3 regulates NOTCH signaling / positive regulation of transcription of Notch receptor target / Notch-HLH transcription pathway / epithelial to mesenchymal transition involved in endocardial cushion formation / heart induction / granulocyte differentiation / cardiac left ventricle morphogenesis / epidermal cell fate specification / pituitary gland development / regulation of DNA methylation-dependent heterochromatin formation / endocardium development / atrioventricular canal development / cardiac muscle cell myoblast differentiation / hair follicle maturation / myeloid dendritic cell differentiation / ventricular trabecula myocardium morphogenesis / positive regulation of ubiquitin-dependent protein catabolic process / positive regulation of BMP signaling pathway / regulation of epithelial cell proliferation / inflammatory response to antigenic stimulus / negative regulation of ossification / negative regulation of cold-induced thermogenesis / labyrinthine layer blood vessel development / artery morphogenesis / ventricular septum morphogenesis / heart looping / outflow tract morphogenesis / erythrocyte maturation / somatic stem cell population maintenance / negative regulation of cell differentiation / humoral immune response / macrophage differentiation / hemopoiesis / epithelial to mesenchymal transition / blood vessel remodeling / cell fate commitment / somitogenesis / negative regulation of stem cell proliferation / keratinocyte differentiation / positive regulation of cardiac muscle cell proliferation / Notch signaling pathway / transcription repressor complex / B cell differentiation / epithelial cell proliferation / stem cell proliferation / positive regulation of epithelial cell proliferation / protein-DNA complex / neuron differentiation / positive regulation of canonical Wnt signaling pathway / chromatin organization / heart development / histone binding / regulation of gene expression / DNA-binding transcription activator activity, RNA polymerase II-specific / angiogenesis / RNA polymerase II-specific DNA-binding transcription factor binding / cell population proliferation / sequence-specific DNA binding / transcription regulator complex / cell differentiation / DNA-binding transcription factor activity, RNA polymerase II-specific / defense response to bacterium / RNA polymerase II cis-regulatory region sequence-specific DNA binding / negative regulation of DNA-templated transcription / chromatin binding / protein-containing complex binding / positive regulation of gene expression / nucleolus / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein-containing complex / DNA binding / zinc ion binding / nucleoplasm / identical protein binding / nucleus Similarity search - Function Beta-trefoil DNA-binding domain / RBP-J/Cbf11/Cbf12, DNA binding / Beta-trefoil domain superfamily / RBP-J/Cbf11, DNA binding domain superfamily / RBP-Jkappa, IPT domain / Suppressor of hairless-like / Beta-trefoil DNA-binding domain / LAG1, DNA binding / TIG domain / LAG1, DNA binding ... Beta-trefoil DNA-binding domain / RBP-J/Cbf11/Cbf12, DNA binding / Beta-trefoil domain superfamily / RBP-J/Cbf11, DNA binding domain superfamily / RBP-Jkappa, IPT domain / Suppressor of hairless-like / Beta-trefoil DNA-binding domain / LAG1, DNA binding / TIG domain / LAG1, DNA binding / Beta-trefoil DNA-binding domain / Zinc finger, C2H2C-type / Zinc finger CCHHC-type profile. / Mbt repeat / MBT repeat profile. / Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2 / mbt repeat / SAM domain (Sterile alpha motif) / p53-like transcription factor, DNA-binding / SAM domain profile. / Sterile alpha motif. / Sterile alpha motif domain / Sterile alpha motif/pointed domain superfamily / Immunoglobulin E-set / Immunoglobulin-like fold Similarity search - Domain/homology DNA / DNA (> 10) / Recombining binding protein suppressor of hairless / Lethal(3)malignant brain tumor-like protein 3 Similarity search - ComponentBiological species Mus musculus (house mouse)Synthetic DNA (others) Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.05 Å DetailsAuthors Hall, D.P. / Kovall, R.A. / Yuan, Z. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Cancer Institute (NIH/NCI) 5RO1CA178974 United States
CitationJournal : Nucleic Acids Res. / Year : 2022Title : The structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3.Authors : Hall, D. / Giaimo, B.D. / Park, S.S. / Hemmer, W. / Friedrich, T. / Ferrante, F. / Bartkuhn, M. / Yuan, Z. / Oswald, F. / Borggrefe, T. / Rual, J.F. / Kovall, R.A. History Deposition Aug 13, 2021 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Aug 24, 2022 Provider : repository / Type : Initial releaseRevision 1.1 Aug 31, 2022 Group : Source and taxonomy / Category : entity_src_gen / pdbx_entity_src_synItem : _entity_src_gen.gene_src_common_name / _pdbx_entity_src_syn.ncbi_taxonomy_id ... _entity_src_gen.gene_src_common_name / _pdbx_entity_src_syn.ncbi_taxonomy_id / _pdbx_entity_src_syn.organism_common_name / _pdbx_entity_src_syn.organism_scientific Revision 1.2 Dec 28, 2022 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.3 Jan 18, 2023 Group : Database references / Category : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_lastRevision 1.4 Oct 25, 2023 Group : Data collection / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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