EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structure-based design of pyrazole derivatives targeting the human Cyclophilin D binding site
ジャーナル・号・ページ	Int. J. Biol. Macromol., Page 151496-, Year 2026
掲載日	2021年5月6日 (構造データの登録日)
著者	Silva, D.O. / Freitas, M.C. / Malta, C.F. / Martins, M.T. / Sousa, P.M. / Matias, P.M. / Schwarz, D. / Ventura, M.R. / Gradler, U. / Bandeiras, T.M.
リンク	Int. J. Biol. Macromol. / PubMedで検索
手法	X線回折
解像度	0.79 - 1.55 Å
構造データ	PDB-7ogi: Human Cyclophilin D in complex with N-(5-ethyl-4-oxo-1,2,3,4,5,6-hexahydro-1,5-benzodiazocin-8-yl)-7methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide 手法: X-RAY DIFFRACTION / 解像度: 1.01 Å PDB-7pmt: Human Cyclophilin D in complex with N-[(5-ethyl-4-oxo-1,2,3,4,5,6- hexahydro-1,5-benzodiazocin-8-yl)methyl]-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide 手法: X-RAY DIFFRACTION / 解像度: 0.98 Å PDB-7r2h: 0.79A resolution structure of DMSO bound Cyclophilin D 手法: X-RAY DIFFRACTION / 解像度: 0.79 Å PDB-7r2i: Human Cyclophilin D in complex with fragment 手法: X-RAY DIFFRACTION / 解像度: 1.31 Å PDB-7r2j: Human Cyclophilin D in complex with N-(4-aminophenyl)-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide 手法: X-RAY DIFFRACTION / 解像度: 1.26 Å PDB-7r2l: Human Cyclophilin D in complex with N-(4-aminophenyl)-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide 手法: X-RAY DIFFRACTION / 解像度: 1.1 Å PDB-7zdn: Human Cyclophilin D in complex with fragment 手法: X-RAY DIFFRACTION / 解像度: 1.55 Å PDB-9f0i: Human Cyclophilin D in complex with fragment 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å
化合物	ChemComp-VDH: N-(5-ethyl-4-oxidanylidene-1,2,3,6-tetrahydro-1,5-benzodiazocin-8-yl)-7-methyl-2-oxidanylidene-1H-pyrazolo[1,5-a]pyrimidine-6-carboxamide ChemComp-DMS: DIMETHYL SULFOXIDE / DMSO, 沈殿剤YM ChemComp-PG4: TETRAETHYLENE GLYCOL / 沈殿剤YM ChemComp-HOH: WATER ChemComp-7UO: ~{N}-[(5-ethyl-4-oxidanylidene-1,2,3,6-tetrahydro-1,5-benzodiazocin-8-yl)methyl]-7-methyl-2-oxidanylidene-1,3-dihydropyrazolo[1,5-a]pyrimidine-6-carboxamide ChemComp-UPZ: ethyl 7-methyl-2-oxidanylidene-1,3-dihydropyrazolo[1,5-a]pyrimidine-6-carboxylate ChemComp-1PE: PENTAETHYLENE GLYCOL / 沈殿剤YM ChemComp-V0Z: N-(4-aminophenyl)-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide ChemComp-UX5: N-(4-aminophenyl)-7-methyl-2-oxo-1H,2H-pyrazolo[1,5-a]pyrimidine-6-carboxamide ChemComp-IU0: (1~{R},9~{R},10~{S})-12-oxa-8-azatricyclo[7.3.1.0^{2,7}]trideca-2(7),3,5-trien-10-ol PDB-1h8q*: Unknown entry
由来	homo sapiens (ヒト)
キーワード	ISOMERASE / Cyclophilin D PPIase