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Structure paper

TitleQuaternary glucocorticoid receptor structure highlights allosteric interdomain communication.
Journal, issue, pagesNat. Struct. Mol. Biol., Vol. 30, Page 286-295, Year 2023
Publish dateSep 22, 2021 (structure data deposition date)
AuthorsPostel, S. / Wissler, L. / Johansson, C.A. / Gunnarsson, A. / Gordon, E. / Collins, B. / Castaldo, M. / Kohler, C. / Oling, D. / Johansson, P. ...Postel, S. / Wissler, L. / Johansson, C.A. / Gunnarsson, A. / Gordon, E. / Collins, B. / Castaldo, M. / Kohler, C. / Oling, D. / Johansson, P. / Froderberg Roth, L. / Beinsteiner, B. / Dainty, I. / Delaney, S. / Klaholz, B.P. / Billas, I.M.L. / Edman, K.
External linksNat. Struct. Mol. Biol. / PubMed:36747092
MethodsX-ray diffraction
Resolution2.2 - 2.7 Å
Structure data

PDB-7prv:
The glucocorticoid receptor in complex with fluticasone furoate, a PGC1a coactivator fragment and sgk 23bp
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-7prw:
The glucocorticoid receptor in complex with velsecorat, a PGC1a coactivator fragment and sgk 23bp
Method: X-RAY DIFFRACTION / Resolution: 2.502 Å

PDB-7prx:
wildtype ligand binding domain of the glucocorticoid receptor complexed with velsecorat and a PGC1a coactivator fragment
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-GW6:
(6alpha,11alpha,14beta,16alpha,17alpha)-6,9-difluoro-17-{[(fluoromethyl)sulfanyl]carbonyl}-11-hydroxy-16-methyl-3-oxoan

ChemComp-HOH:
WATER

ChemComp-82H:
Velsecorat

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / nuclear receptor / ligand-activated transcription factor / multi-domain / complex / agonist

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