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Structure paper

TitleIFN alpha primes cancer cells for Fusicoccin-induced cell death via 14-3-3 PPI stabilization.
Journal, issue, pagesCell Chem Biol, Year 2023
Publish dateApr 21, 2021 (structure data deposition date)
AuthorsAndlovic, B. / Heilmann, G. / Ninck, S. / Andrei, S.A. / Centorrino, F. / Higuchi, Y. / Kato, N. / Brunsveld, L. / Arkin, M. / Menninger, S. ...Andlovic, B. / Heilmann, G. / Ninck, S. / Andrei, S.A. / Centorrino, F. / Higuchi, Y. / Kato, N. / Brunsveld, L. / Arkin, M. / Menninger, S. / Choidas, A. / Wolf, A. / Klebl, B. / Kaschani, F. / Kaiser, M. / Eickhoff, J. / Ottmann, C.
External linksCell Chem Biol / PubMed:37130519
MethodsX-ray diffraction
Resolution1.8 - 2.3 Å
Structure data

PDB-7ob5:
Crystal structure of 14-3-3 sigma in complex with LDB1 phosphopeptide
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-7ob8:
Crystal structure of 14-3-3 sigma in complex with LDB1 phosphopeptide and stabilizer Fusicoccin-A
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-7obc:
Crystal structure of 14-3-3 sigma in complex with Phosphorylated and Farnesylated Rnd3 peptide
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-7obd:
Crystal structure of 14-3-3 sigma in complex with Phosphorylated and Farnesylated Rnd3 peptide and stabilizer Fusicoccin-A
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-7obg:
Crystal structure of 14-3-3 sigma in complex with NPM1 phosphopeptide
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-7obh:
Crystal structure of 14-3-3 sigma in complex with NPM1 phosphopeptide and stabilizer Fusicoccin-A
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-7obk:
Crystal structure of 14-3-3 sigma in complex with PKR phosphopeptide
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-7obl:
Crystal structure of 14-3-3 sigma in complex with PKR phosphopeptide and stabilizer Fusicoccin-A
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-7obs:
Crystal structure of 14-3-3 sigma in complex with RIPK2 phosphopeptide
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-7obt:
Crystal structure of 14-3-3 sigma in complex with RIPK2 phosphopeptide and stabilizer Fusicoccin-A
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-7obx:
Crystal structure of 14-3-3 sigma in complex with SSBP4 phosphopeptide
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-7oby:
Crystal structure of 14-3-3 sigma in complex with SSBP4 phosphopeptide and stabilizer Fusicoccin-A
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-MG:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-FSC:
FUSICOCCIN

ChemComp-FAR:
FARNESYL

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / 14-3-3 sigma protein-peptide complex / 14-3-3 sigma protein-peptide-stabilizer complex / 14-3-3 protein protein-peptide complex / 14-3-3 protein protein-peptide-stabilizer complex / 14-3-3 sigma protein protein-peptide-stabilizer complex

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