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TitleMolecular insights into the unusually promiscuous and catalytically versatile Fe(II)/ alpha-ketoglutarate-dependent oxygenase SptF.
Journal, issue, pagesNat Commun, Vol. 13, Page 95-95, Year 2022
Publish dateJun 1, 2021 (structure data deposition date)
AuthorsTao, H. / Mori, T. / Chen, H. / Lyu, S. / Nonoyama, A. / Lee, S. / Abe, I.
External linksNat Commun / PubMed:35013177
MethodsX-ray diffraction
Resolution1.4 - 2.12 Å
Structure data

PDB-7eyr:
Fe(II)/(alpha)ketoglutarate-dependent dioxygenase SptF apo
Method: X-RAY DIFFRACTION / Resolution: 2.12 Å

PDB-7eys:
Complex structure of SptF with Fe, alpha-ketoglutarate, and andiconin D
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-7eyt:
Fe(II)/(alpha)ketoglutarate-dependent dioxygenase SptF with andilesin C and NOG
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-7eyu:
Fe(II)/(alpha)ketoglutarate-dependent dioxygenase SptF-N65T mutant with andiconin D
Method: X-RAY DIFFRACTION / Resolution: 2.05 Å

PDB-7eyw:
Fe(II)/(alpha)ketoglutarate-dependent dioxygenase SptF with terretonin C
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-7fcb:
SptF 9 residues truncated mutant
Method: X-RAY DIFFRACTION / Resolution: 1.4 Å

Chemicals

ChemComp-FE2:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-AKG:
2-OXOGLUTARIC ACID

ChemComp-0CC:
Andiconin D

ChemComp-OGA:
N-OXALYLGLYCINE / inhibitor*YM

ChemComp-0I3:
Andilesin C

ChemComp-0IP:
Terretonin C

Source
  • aspergillus sp. (mold)
KeywordsOXIDOREDUCTASE / alpha-ketoglutarate dependent dioxygenase / meroterpenoid / SptF / alpha-ketoglutarate dependent oxygenase / biosynthesis

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