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TitleStructural insights into branch site proofreading by human spliceosome
Journal, issue, pagesNat. Struct. Mol. Biol., Year 2024
Publish dateMay 21, 2021 (structure data deposition date)
AuthorsZhang X / Zhan X / Bian T / Yang F / Li P / Lu Y / Xing Z / Fan R / Zhang QC / Shi Y
External linksNat. Struct. Mol. Biol. / Search PubMed
MethodsEM (single particle)
Resolution2.5 - 15.0 Å
Structure data

31330

7evn

EMDB-31330: The cryo-EM map of the DDX42-SF3b complex core region
PDB-7evn: The cryo-EM structure of the DDX42-SF3b complex
Method: EM (single particle) / Resolution: 2.6 Å

31334

7evo

EMDB-31334: The cryo-EM map of the human 17S U2 snRNP core region
PDB-7evo: The cryo-EM structure of the human 17S U2 snRNP
Method: EM (single particle) / Resolution: 2.5 Å

EMDB-31335: The cryo-EM map of U2 snRNP in PRP5 alpha1 region
Method: EM (single particle) / Resolution: 2.9 Å

EMDB-31336: The cryo-EM map of U2 snRNP in PRP5 alpha2 region
Method: EM (single particle) / Resolution: 2.9 Å

EMDB-31337: The cryo-EM map of U2 snRNP in TAT-SF1 region
Method: EM (single particle) / Resolution: 3.8 Å

EMDB-31338: The cryo-EM map of U2 snRNP in BSL region
Method: EM (single particle) / Resolution: 2.8 Å

EMDB-32075: The cryo-EM map of the DNAJC8 region of human pre-A complex
Method: EM (single particle) / Resolution: 3.0 Å

EMDB-32076: The cryo-EM map of the U1 region of human pre-A complex
Method: EM (single particle) / Resolution: 15.0 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-9B0:
[(2~{S},3~{S},4~{E},6~{S},7~{R},10~{R})-3,7-dimethyl-2-[(2~{E},4~{E},6~{R})-6-methyl-6-oxidanyl-7-[(2~{R},3~{R})-3-[(2~{R},3~{S})-3-oxidanylpentan-2-yl]oxiran-2-yl]hepta-2,4-dien-2-yl]-7,10-bis(oxidanyl)-12-oxidanylidene-1-oxacyclododec-4-en-6-yl] 4-cycloheptylpiperazine-1-carboxylate

Source
  • homo sapiens (human)
KeywordsSPLICING / DDX32 / SF3B1 / SF3b / U2 snRNP / PRP5

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