EMDB/PDB/SASBDBから引用されている文献のデータベース

キーワード
構造解析手法	All X線回折 NMR 電子顕微鏡小角散乱中性子線回折線維回折粉末回折赤外分光 EPR FRET 理論モデルハイブリッド
著者・登録者
ジャーナル
IF	>30 >20 >10 >5 all

タイトル	Structural Analysis and Development of Notum Fragment Screening Hits.
ジャーナル・号・ページ	Acs Chem Neurosci, Vol. 13, Page 2060-2077, Year 2022
掲載日	2020年12月2日 (構造データの登録日)
著者	Zhao, Y. / Mahy, W. / Willis, N.J. / Woodward, H.L. / Steadman, D. / Bayle, E.D. / Atkinson, B.N. / Sipthorp, J. / Vecchia, L. / Ruza, R.R. ...Zhao, Y. / Mahy, W. / Willis, N.J. / Woodward, H.L. / Steadman, D. / Bayle, E.D. / Atkinson, B.N. / Sipthorp, J. / Vecchia, L. / Ruza, R.R. / Harlos, K. / Jeganathan, F. / Constantinou, S. / Costa, A. / Kjaer, S. / Bictash, M. / Salinas, P.C. / Whiting, P. / Vincent, J.P. / Fish, P.V. / Jones, E.Y.
リンク	Acs Chem Neurosci / PubMed:35731924
手法	X線回折
解像度	1.24 - 1.94 Å
構造データ	PDB-7b4x: Notum complex with ARUK3002697 手法: X-RAY DIFFRACTION / 解像度: 1.24 Å PDB-7b84: Notum-Fragment065 手法: X-RAY DIFFRACTION / 解像度: 1.36 Å PDB-7b86: Notum-Fragment067 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-7b87: Notum-Fragment074 手法: X-RAY DIFFRACTION / 解像度: 1.58 Å PDB-7b89: Notum-Fragment077 手法: X-RAY DIFFRACTION / 解像度: 1.84 Å PDB-7b8c: Notum-Fragment 147 手法: X-RAY DIFFRACTION / 解像度: 1.43 Å PDB-7b8d: Notum-Fragment 151 手法: X-RAY DIFFRACTION / 解像度: 1.62 Å PDB-7b8f: Notum-Fragment 154 手法: X-RAY DIFFRACTION / 解像度: 1.62 Å PDB-7b8g: Notum-Fragment 159 手法: X-RAY DIFFRACTION / 解像度: 1.58 Å PDB-7b8j: Notum-Fragment 163 手法: X-RAY DIFFRACTION / 解像度: 1.75 Å PDB-7b8k: Notum-Fragment 173 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-7b8l: Notum-Fragment 174 手法: X-RAY DIFFRACTION / 解像度: 1.45 Å PDB-7b8m: Notum-Fragment 193 手法: X-RAY DIFFRACTION / 解像度: 1.48 Å PDB-7b8n: Notum-Fragment 197 手法: X-RAY DIFFRACTION / 解像度: 1.56 Å PDB-7b8o: Notum-Fragment 199 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-7b8u: Notum-Fragment 201 手法: X-RAY DIFFRACTION / 解像度: 1.54 Å PDB-7b8x: Notum-Fragment 210 手法: X-RAY DIFFRACTION / 解像度: 1.51 Å PDB-7b8y: Notum-Fragment 276 手法: X-RAY DIFFRACTION / 解像度: 1.57 Å PDB-7b8z: Notum-Fragment 277 手法: X-RAY DIFFRACTION / 解像度: 1.73 Å PDB-7b98: Notum Fragment 282 手法: X-RAY DIFFRACTION / 解像度: 1.53 Å PDB-7b99: Notum Fragment 283 手法: X-RAY DIFFRACTION / 解像度: 1.81 Å PDB-7b9d: Notum Fragment 290 手法: X-RAY DIFFRACTION / 解像度: 1.93 Å PDB-7b9i: Notum Fragment 297 手法: X-RAY DIFFRACTION / 解像度: 1.34 Å PDB-7b9n: Notum Fragment 588 手法: X-RAY DIFFRACTION / 解像度: 1.38 Å PDB-7b9u: Notum Fragment 609 手法: X-RAY DIFFRACTION / 解像度: 1.5 Å PDB-7ba1: Notum Fragment 634 手法: X-RAY DIFFRACTION / 解像度: 1.93 Å PDB-7bac: Notum Fragment 646 手法: X-RAY DIFFRACTION / 解像度: 1.54 Å PDB-7bap: Notum Fragment 648 手法: X-RAY DIFFRACTION / 解像度: 1.53 Å PDB-7bc8: Notum Fragment 658 手法: X-RAY DIFFRACTION / 解像度: 1.74 Å PDB-7bc9: Notum Fragment 690 手法: X-RAY DIFFRACTION / 解像度: 1.73 Å PDB-7bcc: Notum Fragment 705 手法: X-RAY DIFFRACTION / 解像度: 1.58 Å PDB-7bcd: Notum Fragment 714 手法: X-RAY DIFFRACTION / 解像度: 1.51 Å PDB-7bcf: Notum Fragment 722 手法: X-RAY DIFFRACTION / 解像度: 1.86 Å PDB-7bch: Notum Fragment 772 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-7bci: Notum Fragment 784 手法: X-RAY DIFFRACTION / 解像度: 1.94 Å PDB-7bck: Notum Fragment 791 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-7bcl: Notum Fragment 792 手法: X-RAY DIFFRACTION / 解像度: 1.84 Å PDB-7bd2: Notum Fragment 810 手法: X-RAY DIFFRACTION / 解像度: 1.52 Å PDB-7bd3: Notum Fragment 823 手法: X-RAY DIFFRACTION / 解像度: 1.91 Å PDB-7bd4: Notum Fragment 828 手法: X-RAY DIFFRACTION / 解像度: 1.8 Å PDB-7bd5: Notum Fragment 830 手法: X-RAY DIFFRACTION / 解像度: 1.69 Å PDB-7bd6: Notum Fragment 863 手法: X-RAY DIFFRACTION / 解像度: 1.7 Å PDB-7bd8: Notum Fragment 872 手法: X-RAY DIFFRACTION / 解像度: 1.42 Å PDB-7bd9: Notum Fragment 886 手法: X-RAY DIFFRACTION / 解像度: 1.59 Å PDB-7bda: Notum Fragment 900 手法: X-RAY DIFFRACTION / 解像度: 1.47 Å PDB-7bdb: Notum Fragment 916 手法: X-RAY DIFFRACTION / 解像度: 1.46 Å PDB-7bdc: Notum Fragment 923 手法: X-RAY DIFFRACTION / 解像度: 1.32 Å PDB-7bdd: Notum Fragment 924 手法: X-RAY DIFFRACTION / 解像度: 1.47 Å PDB-7bdf: Notum Fragment 927 手法: X-RAY DIFFRACTION / 解像度: 1.4 Å PDB-7bdg: Notum Fragment 934 手法: X-RAY DIFFRACTION / 解像度: 1.6 Å PDB-7bdh: Notum Fragment 955 手法: X-RAY DIFFRACTION / 解像度: 1.54 Å
化合物	ChemComp-SO4: SULFATE ION / 硫酸ジアニオン / 硫酸塩 ChemComp-DMS: DIMETHYL SULFOXIDE / 2-チアプロパン2-オキシド / DMSO, 沈殿剤YM / ジメチルスルホキシド ChemComp-EDO: 1,2-ETHANEDIOL / エチレングリコ-ル / エチレングリコール ChemComp-SWT: 6-(4-methylphenyl)sulfanyl-2~{H}-[1,2,4]triazolo[4,3-b]pyridazin-3-one ChemComp-HOH: WATER / 水 ChemComp-NAG: 2-acetamido-2-deoxy-beta-D-glucopyranose / N-アセチル-β-D-グルコサミン / N-アセチルグルコサミン ChemComp-JFS: [4-(1H-benzimidazol-1-yl)phenyl]methanol ChemComp-AW7: 2-[4-(1~{H}-pyrazol-3-yl)phenoxy]pyrimidine ChemComp-JFV: methyl 2-(4-aminophenoxy)benzoate ChemComp-T1Z: [1-(3,4-dichlorophenyl)-1,2,3-triazol-4-yl]methanol ChemComp-GRV: 2-methyl-~{N}-(2-methylpropyl)imidazo[1,2-a]pyridine-3-carboxamide ChemComp-SFY: 4-amino-N-(pyridin-2-yl)benzenesulfonamide / スルファピリジン / 薬剤, 抗生剤YM / Sulfapyridine ChemComp-RYM: 4-(benzimidazol-1-ylmethyl)benzenecarbonitrile / 4-(1H-ベンゾイミダゾ-ル-1-イルメチル)ベンゾニトリル ChemComp-MJW: 2-phenylmethoxyaniline / 2-(ベンジルオキシ)アニリン ChemComp-BP4: biphenyl-4-ylacetic acid / フェルビナク / 抗炎症剤YM / フェルビナク ChemComp-AXV: 1~{H}-benzimidazol-2-ylcyanamide ChemComp-AY4: 2,4-bis(fluoranyl)-6-(1~{H}-pyrazol-3-yl)phenol ChemComp-GQM: 5-methoxy-2-(1~{H}-pyrazol-3-yl)phenol ChemComp-GOL: GLYCEROL / グリセロ-ル / グリセリン ChemComp-T2E: 5-azanyl-2-(pyridin-3-ylmethylamino)benzoic acid ChemComp-T1W: [(2~{S})-2-methylpiperidin-1-yl]-morpholin-4-yl-methanone ChemComp-RUY: 4-(piperidin-1-yl)-1,2,5-oxadiazol-3-amine ChemComp-U3K: ~{N}-methyl-~{N}-[(5-methylfuran-2-yl)methyl]-1-phenyl-methanamine ChemComp-T2H: 5-(3-ethoxyphenyl)-1,3,4-thiadiazol-2-amine ChemComp-A6Z: 2-[4-(3-chlorophenyl)piperazin-1-ium-1-yl]ethanenitrile ChemComp-EJW: (3-phenyl-1,2-oxazol-5-yl)methylazanium ChemComp-B1A: ~{N}-(4-phenylazanylphenyl)ethanamide / 4′-(アニリノ)アセトアニリド ChemComp-T3N: 2-(4-acetamidophenoxy)ethanoic acid / LR-86 ChemComp-T3T: 1-(1,3-benzodioxol-5-yl)-~{N}-(pyridin-2-ylmethyl)methanamine ChemComp-N9J: benzyl hydroxycarbamate / ヒドロキシカルバミド酸ベンジル ChemComp-O3D: 4-[(furan-2-yl)methyl]-1lambda~6~,4-thiazinane-1,1-dione ChemComp-S1V: 1-ethanoylpiperidine-4-carbonitrile ChemComp-LO5: 1-(1,3-benzodioxol-5-yl)-~{N}-[[(2~{R})-oxolan-2-yl]methyl]methanamine ChemComp-S4V: ~{N}2-pyridin-2-ylbenzene-1,2-diamine ChemComp-TAH: 2-(benzyloxy)benzohydrazide ChemComp-UR4: 2-methoxy-N-(4-phenyl-1,3-thiazol-2-yl)acetamide ChemComp-TB5: 4-(4-pyrrol-1-ylphenyl)morpholine ChemComp-T9Z: 2-(morpholin-4-ium-4-ylmethyl)naphthalen-1-ol ChemComp-T9W: 2-[4-(2,5-Dioxopyrrolidin-1-yl)phenoxy]acetate ChemComp-T9Q: N-Benzyl-2-methoxyacetamide / N-ベンジル-2-メトキシアセトアミド ChemComp-GVV: ~{N}-(4-methyl-2-oxidanyl-phenyl)propanamide ChemComp-T9B: (2S)-N-(4-Methoxybenzyl)tetrahydrofuran-2-carboxamide / (2S)-N-(4-メトキシベンジル)テトラヒドロフラン-2-カルボアミド ChemComp-T9K: methyl 2-(4-cyanophenoxy)ethanoate ChemComp-NUM: N-[2-(4-hydroxyphenyl)ethyl]pyridine-2-carboxamide ChemComp-TE5: 4-methoxy-6-phenyl-pyrimidin-2-amine ChemComp-JHJ: N-(4-methoxyphenyl)-N'-pyridin-4-ylurea / 1-[(4-メトキシフェニル)]-3-(ピリジン-4-イル)尿素 ChemComp-YI6: 2-(4-ethoxyphenyl)ethanoic acid / 4-エトキシフェニル酢酸 ChemComp-JH7: 1-methyl-5-(phenylamino)-1,2-dihydro-3H-pyrazol-3-one ChemComp-QL5: (2,5-dimethylphenyl) pyridine-4-carboxylate ChemComp-GW1: (4-chloranyl-2-methyl-pyrazol-3-yl)-piperidin-1-yl-methanone ChemComp-O1J: (benzyloxy)acetic acid / ベンジルオキシ酢酸 ChemComp-NW7: 3-ethyl-5-methyl-N-(5-methyl-1,2-oxazol-3-yl)-1,2-oxazole-4-carboxamide ChemComp-WNA: 1-methyl-N-[(2-methylphenyl)methyl]-1H-tetrazol-5-amine ChemComp-TE8: (2~{R})-2-(4-phenylphenoxy)propanoic acid / (R)-2-[(ビフェニル-4-イル)オキシ]プロパン酸 ChemComp-TEH: 4-(2-phenoxyethanoyl)piperazin-2-one ChemComp-TEK: ~{N}-(1-ethylbenzimidazol-2-yl)ethanamide ChemComp-TEZ*: N-(2,1,3-Benzothiadiazol-5-yl)acetamide
由来	homo sapiens (ヒト)
キーワード	HYDROLASE (加水分解酵素) / Notum Inhibitor complex / Notum Fragment / Notum Inhibitor / Notum Inhibitor Wnt / Notum Inhibitor Fragment Screen