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TitleSelf-association of MreC as a regulatory signal in bacterial cell wall elongation.
Journal, issue, pagesNat Commun, Vol. 12, Issue 1, Page 2987, Year 2021
Publish dateMay 20, 2021
AuthorsAlexandre Martins / Carlos Contreras-Martel / Manon Janet-Maitre / Mayara M Miyachiro / Leandro F Estrozi / Daniel Maragno Trindade / Caíque C Malospirito / Fernanda Rodrigues-Costa / Lionel Imbert / Viviana Job / Guy Schoehn / Ina Attrée / Andréa Dessen /
PubMed AbstractThe elongasome, or Rod system, is a protein complex that controls cell wall formation in rod-shaped bacteria. MreC is a membrane-associated elongasome component that co-localizes with the ...The elongasome, or Rod system, is a protein complex that controls cell wall formation in rod-shaped bacteria. MreC is a membrane-associated elongasome component that co-localizes with the cytoskeletal element MreB and regulates the activity of cell wall biosynthesis enzymes, in a process that may be dependent on MreC self-association. Here, we use electron cryo-microscopy and X-ray crystallography to determine the structure of a self-associated form of MreC from Pseudomonas aeruginosa in atomic detail. MreC monomers interact in head-to-tail fashion. Longitudinal and lateral interfaces are essential for oligomerization in vitro, and a phylogenetic analysis of proteobacterial MreC sequences indicates the prevalence of the identified interfaces. Our results are consistent with a model where MreC's ability to alternate between self-association and interaction with the cell wall biosynthesis machinery plays a key role in the regulation of elongasome activity.
External linksNat Commun / PubMed:34016967 / PubMed Central
MethodsEM (helical sym.) / X-ray diffraction
Resolution1.471 - 3.5 Å
Structure data

11275

6zlv

EMDB-11275, PDB-6zlv:
MreC
Method: EM (helical sym.) / Resolution: 3.5 Å

PDB-6zm0:
Crystal structure of MreC from Pseudomonas aeruginosa
Method: X-RAY DIFFRACTION / Resolution: 1.471 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • pseudomonas aeruginosa (bacteria)
  • pseudomonas aeruginosa pao1 (bacteria)
KeywordsSTRUCTURAL PROTEIN / bacterial cell wall elongation / Rod-Shape Bacteria / Peptidoglycan / elongasome / cytoskeletal

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